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Found 44 with Last Name = 'dragone' and Initial = 'p'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM186204(US9163013, 21)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM186202(US9163013, 19)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  20nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314399(US9611249, Compound 30 | {4-[({[5-(5-methoxypyridi...)
Affinity DataIC50:  20nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM186200(US9163013, 17)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314371(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(p...)
Affinity DataIC50:  30nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314398(US9611249, Compound 29 | {4-[({[5-(2,3-difluorophe...)
Affinity DataIC50:  30nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314382(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(5...)
Affinity DataIC50:  30nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314387(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(6...)
Affinity DataIC50:  50nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314374(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Affinity DataIC50:  50nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314378(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(6...)
Affinity DataIC50:  60nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314377(5-(2-fluorophenyl)-N-{[1-(2- methoxyethyl)piperidi...)
Affinity DataIC50:  70nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314396(US9611249, Compound 27 | {4-[({[5-(2,3-dichlorophe...)
Affinity DataIC50:  100nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314397(US9611249, Compound 28 | {4-[({[5-(3-fluorophenyl)...)
Affinity DataIC50:  110nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314381(N-{[1-(2-methoxyethyl)pipendin-4- yl]methyl}-5-phe...)
Affinity DataIC50:  200nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134914(CHEMBL3735730)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314391(US9611249, Compound 25 | US9611249, Compound 25b |...)
Affinity DataIC50:  220nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 7(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human recombinant ERK5 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM186201(US9163013, 18)
Affinity DataIC50:  300nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant GRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134187(CHEMBL3735506 | US11472795, Example C | US9611249,...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant DYRK2 by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM50134188(CHEMBL3735095)
Affinity DataIC50:  530nMAssay Description:Inhibition of human recombinant GSK-3beta using Ulight-CFFKNIVTPRTPPPSQQGK-amide as substrate after 90 mins by LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314391(US9611249, Compound 25 | US9611249, Compound 25b |...)
Affinity DataIC50:  530nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314384(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Affinity DataIC50:  560nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314385(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(4...)
Affinity DataIC50:  560nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314388(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(2...)
Affinity DataIC50:  580nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314324(US9611249, Compound 1 | [4-({[(5-methoxy-1H-indazo...)
Affinity DataIC50:  670nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314370(US9611249, Compound 3 | [4-({[(5-methoxy-1H-indazo...)
Affinity DataIC50:  690nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314407(N-[(1-{3-[(2E)-but-2-enoylamino]propyl} piperidin-...)
Affinity DataIC50:  780nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314368(5-methoxy-N-{[1-(2-methoxyethyl)- piperidin-4-yl]m...)
Affinity DataIC50:  870nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314409(N-({1-[3-(but-2-ynoylamino)propyl] piperidin-4-yl}...)
Affinity DataIC50:  880nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314383(5-(4-hydroxyphenyl)-N-{[1-(2- methoxyethyl)piperid...)
Affinity DataIC50:  890nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314395(US9611249, Compound 26 | {4-[({[5-(3,5-Dimethyliso...)
Affinity DataIC50:  910nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314408(5-methoxy-N-({1-[3-(propanoylamino) propyl]piperid...)
Affinity DataIC50:  950nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314400(US9611249, Compound 31 | [4-({[(5-ethyl-1H-indazol...)
Affinity DataIC50:  960nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314406(N-({1-[3-(butanoylamino)propyl] piperidin-4-yl}met...)
Affinity DataIC50:  970nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314390(4-[4-({[(5-methoxy-1H-indazol-3-yl) carbonyl]amino...)
Affinity DataIC50:  1.03E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314402(US9611249, Compound 33 | {4-[({[5-(3,6-dihydro-2H-...)
Affinity DataIC50:  1.04E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314389(5-(2-ethoxy-4,5-difluorophenyl)-N- {[1-(2-methoxye...)
Affinity DataIC50:  1.06E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314403(US9611249, Compound 34 | [4-({[(5-cyclohexyl-1H-in...)
Affinity DataIC50:  1.07E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314386(N-{[1-(2-methoxyethyl)piperidin-4- yl]methyl}-5-(2...)
Affinity DataIC50:  1.40E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314404(US9611249, Compound 35 | [4-({[(5-pentyl-1H-indazo...)
Affinity DataIC50:  2.04E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314405(5-methoxy-N-[(1-{3- [(phenylcarbonyl)amino]propyl}...)
Affinity DataIC50:  3.42E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Angelini

Curated by ChEMBL
LigandPNGBDBM314401(US9611249, Compound 32 | {4-[({[5-(propan-2-yl)-1H...)
Affinity DataIC50:  3.91E+3nMAssay Description:Activity on human GSK-3β was assessed using the following methods (according to Meijer et al., Chem. Biol., 2003-10:1255-1266).In a first screen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent