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Found 1422 with Last Name = 'edmunds' and Initial = 'jj'
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096629(3-(4-Amino-cyclohexyl)-2-oxo-3-[((6S,8aS)-4-oxo-2-...)
Affinity DataKi:  0.0900nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072528((6S,8aS)-2-[3-(3,4-Dichloro-phenyl)-propionyl]-4-o...)
Affinity DataKi:  0.106nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096623(3-(4-Amino-cyclohexyl)-2-oxo-3-[(4-oxo-2-phenylmet...)
Affinity DataKi:  0.130nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096628(3-(4-Amino-cyclohexyl)-2-oxo-3-[((6S,8aS)-4-oxo-2-...)
Affinity DataKi:  0.260nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096620((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  0.330nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072536((6S,8aS)-2-(3-Naphthalen-1-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072537((6S,8aS)-2-[3-(4-Methoxy-phenyl)-propionyl]-4-oxo-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072527((6S,8aS)-4-Oxo-2-(3-p-tolyl-propionyl)-octahydro-p...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072534((6S,8aS)-2-(3-Naphthalen-2-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072524((6S,8aS)-4-Oxo-2-[3-(2-trifluoromethyl-phenyl)-pro...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072532((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Rattus norvegicus)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50072740((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:In vitro ability of the compound to inhibit the amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50347563(CHEMBL1801740)
Affinity DataKi:  0.690nMAssay Description:Binding affinity to human Angiotensin receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096621((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  0.720nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072520((6S,8aS)-2-[3-(2-Fluoro-phenyl)-propionyl]-4-oxo-o...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111673((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  1nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111661((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  1nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50080924(CHEMBL83260 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072533((6S,8aS)-4-Oxo-2-(4-phenyl-butyryl)-octahydro-pyrr...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111658((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111675((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111665((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111672((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  2nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096622(CHEMBL3084834 | {3-(4-Amino-cyclohexyl)-2-oxo-3-[(...)
Affinity DataKi:  2.10nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072530((6S,8aS)-4-Oxo-2-phenylacetyl-octahydro-pyrrolo[1,...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072541((6S,8aS)-4-Oxo-2-(3-pyridin-2-yl-propionyl)-octahy...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072519((6S,8aS)-2-[(S)-2-Amino-3-(4-fluoro-phenyl)-propio...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096630((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  3.20nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50080911(2-((S)-4-Benzyl-2-naphthalen-2-ylmethyl-3,6-dioxo-...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory concentration of the compound required against thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072529((6S,8aS)-2-((S)-2-Hydroxy-3-phenyl-propionyl)-4-ox...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111676((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  5nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111671((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  5nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072535((6S,8aS)-4-Oxo-2-(3-phenoxy-propionyl)-octahydro-p...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50096627((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  5nMAssay Description:In vitro activity of the compound against human alpha thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Rattus norvegicus)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107062((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  7nMAssay Description:In vitro ability of the compound to inhibit the amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111674((6S,8aS)-2-(2,2-Diphenyl-ethanesulfonyl)-4-oxo-oct...)
Affinity DataKi:  8nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Rattus norvegicus)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107060((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  8nMAssay Description:In vitro ability of the compound to inhibit the amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50080920(CHEMBL313769 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111669((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  9nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111663((6S,8aS)-2-(Diphenyl-methanesulfonyl)-4-oxo-octahy...)
Affinity DataKi:  10nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Rattus norvegicus)
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50107064((6S,8aS)-4-Oxo-2-phenylmethanesulfonyl-octahydro-p...)
Affinity DataKi:  14nMAssay Description:In vitro ability of the compound to inhibit the amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080895(CHEMBL311198 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity of the compound against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50111667((6S,8aS)-4-Oxo-2-(2-phenyl-ethanesulfonyl)-octahyd...)
Affinity DataKi:  14nMAssay Description:Inhibition of amidolytic activity of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072521((6S,8aS)-4-Oxo-2-(2-phenoxy-acetyl)-octahydro-pyrr...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072538((6S,8aS)-4-Oxo-2-(3-phenyl-propyl)-octahydro-pyrro...)
Affinity DataKi:  17nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50080916(CHEMBL84084 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50072539((6S,8aS)-2-(3-Cyclohexyl-propionyl)-4-oxo-octahydr...)
Affinity DataKi:  24nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Pharma

Curated by ChEMBL
LigandPNGBDBM50080908(2-[(S)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  24nMAssay Description:Binding affinity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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