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Found 293 with Last Name = 'el-kattan' and Initial = 'y'
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM5024((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...)
Affinity DataIC50: <1nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM5025(Oseltamivir | US10919856, POSITIVE CONTROL | ethyl...)
Affinity DataIC50: <1nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM5023((-)-(1R,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbuty...)
Affinity DataIC50: <1nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5024((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...)
Affinity DataIC50:  1.40nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza A virusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  1.70nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza B virus.More data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM4934((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R...)
Affinity DataIC50:  2nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
TargetHemagglutinin(Influenza B virus (B/Victoria/70))
Biocryst Pharmaceuticals

LigandPNGBDBM5023((-)-(1R,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylbuty...)
Affinity DataIC50:  2nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM4994((3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)c...)
Affinity DataIC50:  2.20nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza A virusMore data for this Ligand-Target Pair
TargetNeuraminidase(Influenza A virus (A/Puerto Rico/8/34/Mount Sinai(...)
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50330326((4S,5R,6R)-5-Acetylamino-4-guanidino-6-((1R,3R)-1,...)
Affinity DataIC50:  2.30nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza A virusMore data for this Ligand-Target Pair
TargetHemagglutinin(Influenza B virus (B/Victoria/70))
Biocryst Pharmaceuticals

LigandPNGBDBM5024((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...)
Affinity DataIC50:  5nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza B virus (B/Victoria/70))
Biocryst Pharmaceuticals

LigandPNGBDBM5025(Oseltamivir | US10919856, POSITIVE CONTROL | ethyl...)
Affinity DataIC50:  5nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31501(substituted biphenyl derivative, 36ao)
Affinity DataIC50:  8nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31499(substituted biphenyl derivative, 36am)
Affinity DataIC50:  9nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31468(substituted biphenyl derivative, 36h)
Affinity DataIC50:  9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31488(substituted biphenyl derivative, 36ab)
Affinity DataIC50:  9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31462(substituted biphenyl derivative, 36b)
Affinity DataIC50:  9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31497(substituted biphenyl derivative, 36ak)
Affinity DataIC50:  9nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31486(substituted biphenyl derivative, 36z)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31487(substituted biphenyl derivative, 36aa)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31500(substituted biphenyl derivative, 36an)
Affinity DataIC50:  10nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31489(substituted biphenyl derivative, 36ac)
Affinity DataIC50:  11nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31493(substituted biphenyl derivative, 36ag)
Affinity DataIC50:  11nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5024((-)-(1S,2S,3R,4R)-3-[(1S)-1-(Acetylamino)-2-ethylb...)
Affinity DataIC50:  11nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza B virus.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31470(substituted biphenyl derivative, 36j)
Affinity DataIC50:  11nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31474(substituted biphenyl derivative, 36n)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM5021((1R,3R,4R)-3-carbamimidamido-4-[(1S)-1-acetamidope...)
Affinity DataIC50:  13nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31467(substituted biphenyl derivative, 36g)
Affinity DataIC50:  13nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31490(substituted biphenyl derivative, 36ad)
Affinity DataIC50:  14nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (N9))
Biocryst Pharmaceuticals

LigandPNGBDBM4758((3S,4S)-3-carbamimidamido-4-[(S)-(diethylcarbamoyl...)
Affinity DataIC50:  15nMAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza B virus (B/Victoria/70))
Biocryst Pharmaceuticals

LigandPNGBDBM4934((2R,3R,4S)-4-carbamimidamido-3-acetamido-2-[(1R,2R...)
Affinity DataIC50:  17nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31501(substituted biphenyl derivative, 36ao)
Affinity DataIC50:  20nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31502(substituted biphenyl derivative, 36ap)
Affinity DataIC50:  20nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50:  21nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
Biocryst Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM4994((3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)c...)
Affinity DataIC50:  24nMAssay Description:inhibitory concentration required to inhibit neuraminidase enzyme from different strains of influenza B virus.More data for this Ligand-Target Pair
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31503(substituted biphenyl derivative, 36aq)
Affinity DataIC50:  24nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31466(substituted biphenyl derivative, 36f)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
Biocryst Pharmaceuticals

LigandPNGBDBM5019((3R*,4R*)-3-[(1S*)-1-(Acetylamino)pentyl]-4-{[amin...)
Affinity DataIC50:  25nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31475(substituted biphenyl derivative, 36o)
Affinity DataIC50:  29nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31461(substituted biphenyl derivative, 24)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31500(substituted biphenyl derivative, 36an)
Affinity DataIC50:  33nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31469(substituted biphenyl derivative, 36i)
Affinity DataIC50:  34nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31487(substituted biphenyl derivative, 36aa)
Affinity DataIC50:  35nMT: 2°CAssay Description:The assay is an amidolytic assay based upon the absorbance of derivatized thiols from the hydrolysis of Z-Lys-SBzl (Bachem) in the presence of 5,5-Di...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31495(substituted biphenyl derivative, 36ai)
Affinity DataIC50:  36nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31487(substituted biphenyl derivative, 36aa)
Affinity DataIC50:  40nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (N9))
Biocryst Pharmaceuticals

LigandPNGBDBM4775((3S,4S)-3-carbamimidamido-4-[(1S)-1-acetamido-2-(m...)
Affinity DataIC50:  40nMAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31464(substituted biphenyl derivative, 36d)
Affinity DataIC50:  42nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHemagglutinin(Influenza B virus (B/Victoria/70))
Biocryst Pharmaceuticals

LigandPNGBDBM5019((3R*,4R*)-3-[(1S*)-1-(Acetylamino)pentyl]-4-{[amin...)
Affinity DataIC50:  43nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31471(substituted biphenyl derivative, 36k)
Affinity DataIC50:  45nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31491(substituted biphenyl derivative, 36ae)
Affinity DataIC50:  50nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Biocryst Pharmaceuticals

LigandPNGBDBM31499(substituted biphenyl derivative, 36am)
Affinity DataIC50:  50nMT: 2°CAssay Description:FXa assay reactions were performed in a reaction mixture containing FXa, and test compounds were added at varied concentrations and reactions were in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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