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Found 351 with Last Name = 'engel' and Initial = 'c'
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306596(3-(4-((S)-4-methyl-2-(quinolin-6-ylmethylamino)pen...)
Affinity DataKi:  100nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306600(3-(4-((S)-1-cyclopentyl-1-(quinolin-6-ylmethylamin...)
Affinity DataKi:  110nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306598(3-(4-((S)-1-cyclobutyl-1-(quinolin-6-ylmethylamino...)
Affinity DataKi:  130nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306597(3-(4-((S)-4-methyl-2-(quinolin-6-ylmethylamino)pen...)
Affinity DataKi:  190nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306599(3-(4-((S)-1-cyclobutyl-1-(quinolin-6-ylmethylamino...)
Affinity DataKi:  350nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306592(3-(4-((S)-3-methyl-2-(quinolin-6-ylmethylamino)but...)
Affinity DataKi:  460nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128869(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)
Affinity DataKi:  500nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128871(CHEMBL313154 | Chrysen-6-ylamine)
Affinity DataKi:  600nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306595(3-(4-((S)-1-cyclopropyl-1-(quinolin-6-ylmethylamin...)
Affinity DataKi:  940nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306593(3-(4-((S)-3-methyl-2-(quinolin-6-ylmethylamino)but...)
Affinity DataKi:  1.04E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306601(3-(4-((S)-1-cyclohexyl-1-(quinolin-6-ylmethylamino...)
Affinity DataKi:  1.22E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128867(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)
Affinity DataKi:  2.00E+3nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128866(2-(2,4,7-Trinitro-fluoren-9-ylidene)-malononitrile...)
Affinity DataKi:  2.20E+3nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128872(6-Fluoro-chrysene | CHEMBL83242)
Affinity DataKi:  2.80E+3nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128866(2-(2,4,7-Trinitro-fluoren-9-ylidene)-malononitrile...)
Affinity DataKi:  5.40E+3nMAssay Description:Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128865(6-Nitro-chrysene | CHEMBL82858)
Affinity DataKi:  6.70E+3nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
University Of California

Curated by ChEMBL
LigandPNGBDBM50306594(3-(4-((S)-3-methyl-2-(quinolin-6-ylmethylamino)but...)
Affinity DataKi:  6.76E+3nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128870(CHEMBL85685 | chrysene)
Affinity DataKi:  8.98E+3nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128867(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)
Affinity DataKi:  1.09E+4nMAssay Description:Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128868(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)
Affinity DataKi:  1.18E+4nMAssay Description:Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128867(3,5-diphenyl-4'-methyl-2-nitrobiphenyl | CHEMBL875...)
Affinity DataKi:  1.39E+4nMAssay Description:Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128869(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)
Affinity DataKi:  1.60E+4nMAssay Description:Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82204(Substrate analogue, 28)
Affinity DataKi:  2.00E+4nM ΔG°:  -27.9kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82199(Substrate analogue, 18)
Affinity DataKi:  2.10E+4nM ΔG°:  -27.8kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128869(2,2-Dichloro-N-chrysen-6-yl-acetamide | CHEMBL8805...)
Affinity DataKi: >2.50E+4nMAssay Description:Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82198(Substrate analogue, 17)
Affinity DataKi:  2.80E+4nM ΔG°:  -27.0kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128868(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)
Affinity DataKi:  2.88E+4nMAssay Description:Kinetic inhibition constant of compound with human Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82205(Substrate analogue, 29)
Affinity DataKi:  3.00E+4nM ΔG°:  -26.9kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50128868(5-(2,4-Dichloro-phenoxy)-3-(2-fluoro-phenyl)-[1,2,...)
Affinity DataKi:  4.81E+4nMAssay Description:Kinetic inhibition constant of compound with bacterial Hypoxanthine Phosphoribosyltransferase (HPRT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82192(Substrate analogue, 9)
Affinity DataKi:  8.50E+4nM ΔG°:  -24.2kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82203(Substrate analogue, 24)
Affinity DataKi:  2.43E+5nM ΔG°:  -21.5kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82200(Substrate analogue, 19)
Affinity DataKi:  1.88E+6nM ΔG°:  -16.2kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82191(Substrate analogue, 8)
Affinity DataKi:  2.20E+6nM ΔG°:  -15.8kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82206(Substrate analogue, 31)
Affinity DataKi:  4.90E+6nM ΔG°:  -13.7kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM26121(SUCCINIC ACID | Substrate analogue, 11 | Succinate...)
Affinity DataKi:  1.25E+7nM ΔG°:  -11.3kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82208(Substrate analogue, 33)
Affinity DataKi:  1.82E+7nM ΔG°:  -10.3kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82196(Substrate analogue, 14)
Affinity DataKi:  1.82E+7nM ΔG°:  -10.3kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82197(Substrate analogue, 15)
Affinity DataKi:  1.88E+7nM ΔG°:  -10.2kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82207(Substrate analogue, 32)
Affinity DataKi:  2.29E+7nM ΔG°:  -9.74kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82195(Substrate analogue, 13)
Affinity DataKi:  2.45E+7nM ΔG°:  -9.56kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82194(Substrate analogue, 12)
Affinity DataKi:  3.64E+7nM ΔG°:  -8.54kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82193(Substrate analogue, 10)
Affinity DataKi:  3.84E+7nM ΔG°:  -8.41kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82201(Substrate analogue, 20)
Affinity DataKi:  4.49E+7nM ΔG°:  -8.00kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM50137044(Substrate analogue, 16 | [(ammonioacetyl)amino]ace...)
Affinity DataKi: >1.50E+8nM ΔG°: >-4.89kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-aminolevulinic acid dehydratase(Escherichia coli)
University Of NeuchÂTel

LigandPNGBDBM82202(Substrate analogue, 22)
Affinity DataKi:  2.23E+8nM ΔG°:  -3.87kJ/molepH: 8.1 T: 2°CAssay Description:The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent). More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50433404(CHEMBL2380641)
Affinity DataIC50:  1nMAssay Description:Inhibition of mouse recombinant 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50433406(CHEMBL2380643)
Affinity DataIC50:  1nMAssay Description:Inhibition of mouse recombinant 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Sanofi R & D

Curated by ChEMBL
LigandPNGBDBM50433405(CHEMBL2380642)
Affinity DataIC50:  2nMAssay Description:Inhibition of mouse recombinant 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Sanofi Deutschland

Curated by ChEMBL
LigandPNGBDBM50438080(CHEMBL2409607)
Affinity DataIC50:  4nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Sanofi Deutschland

Curated by ChEMBL
LigandPNGBDBM50438083(CHEMBL2409755)
Affinity DataIC50:  4nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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