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Found 122 with Last Name = 'england' and Initial = 'pm'
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392801(CHEMBL2151247)
Affinity DataKi:  0.324nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50000787((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10,17-dihydr...)
Affinity DataKi:  0.646nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50370067(CHEMBL1237164)
Affinity DataKi:  2.63nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataKi:  5.01nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392797(CHEMBL2151327)
Affinity DataKi:  9.77nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50370067(CHEMBL1237164)
Affinity DataKi:  16.6nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  16.6nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392799(CHEMBL2151245)
Affinity DataKi:  19.9nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392802(CHEMBL2151248)
Affinity DataKi:  22.4nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392801(CHEMBL2151247)
Affinity DataKi:  30.9nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392798(CHEMBL2151328)
Affinity DataKi:  91.2nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392798(CHEMBL2151328)
Affinity DataKi:  120nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50194110((S)-N-(1-(7-(4-aminobutylamino)heptylamino)-3-(4-h...)
Affinity DataKi:  168nMAssay Description:Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM glutamate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392797(CHEMBL2151327)
Affinity DataKi:  204nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392800(CHEMBL2151246)
Affinity DataKi:  550nMAssay Description:Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataKi:  724nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
TBA

Curated by ChEMBL
LigandPNGBDBM50392800(CHEMBL2151246)
Affinity DataKi:  2.88E+3nMAssay Description:Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  15nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50105843(2-Amino-N-{3-[4-(3-amino-propylamino)-butylamino]-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant GluA3 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current by patch ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50105843(2-Amino-N-{3-[4-(3-amino-propylamino)-butylamino]-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced current by patch ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
University Of California

Curated by ChEMBL
LigandPNGBDBM50316374(CHEMBL1096289 | N-(4-hydroxyphenylpropanyl)-spermi...)
Affinity DataIC50:  64nMAssay Description:Inhibition of rat recombinant GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  190nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  230nMAssay Description:Inhibition of GluA3 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant GluA3 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Rattus norvegicus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50316374(CHEMBL1096289 | N-(4-hydroxyphenylpropanyl)-spermi...)
Affinity DataIC50:  320nMAssay Description:Inhibition of rat recombinant GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  350nMAssay Description:Inhibition of GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  350nMAssay Description:Inhibition of recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  360nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 4(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  430nMAssay Description:Inhibition of GluA4 receptor expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced current by patch clamp electrophysiologica...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316374(CHEMBL1096289 | N-(4-hydroxyphenylpropanyl)-spermi...)
Affinity DataIC50:  460nMAssay Description:Inhibition of rat recombinant GluA1 receptor expressed in Xenopus oocytes assessed as inhibition of 300 uM kainate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM239191(US10053433, FC 3.077)
Affinity DataIC50:  490nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM242618(US10053433, FC 4.025)
Affinity DataIC50:  580nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM242588(US10053433, FC 4.039)
Affinity DataIC50:  750nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM238895(US10053433, Casodex (CDX) | US10053433, FC 4.037 (...)
Affinity DataIC50:  1.00E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50253632(6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione |...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of GluR2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM242618(US10053433, FC 4.025)
Affinity DataIC50:  1.29E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM239363(US10053433, FC 4.126)
Affinity DataIC50:  1.55E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataIC50:  1.94E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM239316(US10053433, FC 4.116)
Affinity DataIC50:  2.53E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of California

Curated by ChEMBL
LigandPNGBDBM50094298(CHEMBL16117 | N-[(S)-1-{3-[4-(3-Amino-propylamino)...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataIC50:  3.11E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataIC50:  3.28E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  3.40E+3nMAssay Description:Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as effect of 100 uM kainate-induced current by patch clamp ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Rattus norvegicus (Rat))
University Of California

Curated by ChEMBL
LigandPNGBDBM50316373(Argiotoxin-636 | CHEMBL1098240)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of rat recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes assessed as inhibition of 100 uM kainate-induced currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM242578(US10053433, FC 4.127)
Affinity DataIC50:  7.26E+3nMpH: 7.5Assay Description:Briefly, the AR LBD is expressed as a fusion with the Gal4 transcription factor, which binds to the Gal4 reporter DNA. Upon activation with agonist h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50253650(CHEMBL462490 | [1,2,5]oxadiazolo[3,4-g]quinoxaline...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of GluR2 receptor (unknown origin)More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataIC50:  8.61E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM242578(US10053433, FC 4.127)
Affinity DataIC50:  8.74E+3nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM239363(US10053433, FC 4.126)
Affinity DataIC50:  1.24E+4nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAndrogen receptor(Homo sapiens (Human))
The Regents Of The University Of California

US Patent
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataIC50:  1.95E+4nMpH: 7.5Assay Description:An AR-response element is contained within the mmTV sequence and drives the expression of luciferase. The effect of antiandrogens (competitive antago...More data for this Ligand-Target Pair
In DepthDetails US Patent
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