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Found 320 with Last Name = 'eskra' and Initial = 'jd'
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50284680((3S,4S)-3-Pyridin-3-ylmethyl-6-(quinolin-2-ylmetho...)
Affinity DataKi:  650nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50284682(2-Benzyl-7-(quinolin-2-ylmethoxy)-1,2,3,4-tetrahyd...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50284681(2-Butyl-7-(quinolin-2-ylmethoxy)-1,2,3,4-tetrahydr...)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50012434((REV-5,901)1-[3-(Quinolin-2-ylmethoxy)-phenyl]-hex...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50070921(3-[(3R,4R)-6-(5-Fluoro-benzothiazol-2-ylmethoxy)-4...)
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of [3H]-LTD4 binding to LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224846(4-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224838(1-{6-[4-(6-fluoro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224842(1-(6-{4-[4-(3-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224852(1-{6-[4-(6-chloro-1H-benzoimidazol-2-yl)-phenoxy]-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224847(3-(2-{4-[5-(6,8,10-trioxo-1,7,9-triaza-spiro[4.5]d...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224856(1-{6-[4-(1H-benzoimidazol-2-yl)-phenoxy]-pyridin-3...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224837(1-(6-{4-[4-(4-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224857(1-(6-{4-[4-(2-fluoro-phenyl)-oxazol-2-yl]-phenoxy}...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148216(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of matrix metalloprotease-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148208(3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-ox...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194286(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-3-yl)oxazol-...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451954(CHEMBL2111753)
Affinity DataIC50:  0.350nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194306(5-(2-ethoxyethyl)-5-(4-(4-(4-(3-fluorophenyl)oxazo...)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148214((R)-3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-...)
Affinity DataIC50:  0.370nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194278(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahydropyri...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194292(5-(2-ethoxyethyl)-5-(4-(4-(4-(pyridin-4-yl)oxazol-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148208(3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-ox...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224845(5-(2-ethoxyethyl)-5-(4-(4-(6-fluoro-1H-benzo[d]imi...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194301(4-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194301(4-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194284(5-(4-(4-(4-(3-fluorophenyl)oxazol-2-yl)phenoxy)phe...)
Affinity DataIC50:  0.460nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224853(5-(4-(4-(1H-benzo[d]imidazol-2-yl)phenoxy)phenoxy)...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148208(3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-8-ox...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194304(3-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148228(1-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-cycl...)
Affinity DataIC50:  0.530nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194304(3-(2-(4-(4-(5-(2-ethoxyethyl)-2,4,6-trioxo-hexahyd...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194297(5-(2-ethoxyethyl)-5-(4-(4-(3-(pyridin-4-yl)-1,2,4-...)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163809(5-Amino-3-(2-ethoxy-ethyl)-3-[4-(4-oxazol-5-yl-phe...)
Affinity DataIC50:  0.540nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50129986((4-Benzyl-benzyl)-[4-(4-chloro-phenyl)-2-((S)-2,2-...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148198(4-[4-(3-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50:  0.560nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194290(5-(4-(4-(4-(4-fluorophenyl)oxazol-2-yl)phenoxy)phe...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224854(5-(2-ethoxyethyl)-5-[4-(4-fluorophenoxy)phenoxy]ba...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224849(1-[6-(4-bromo-phenoxy)-pyridin-3-yl]-1,7,9-triaza-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50163808(5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(1H-pyrazol-4-y...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194285(3-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148204(3-[4-(4-Chloro-phenoxy)-benzenesulfonylamino]-8-ox...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148232(4-[4-(2-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50:  0.650nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194289(5-(2-ethoxy-ethyl)-5-(4-{4-[4-(4-fluoro-phenyl)-ox...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194289(5-(2-ethoxy-ethyl)-5-(4-{4-[4-(4-fluoro-phenyl)-ox...)
Affinity DataIC50:  0.680nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194293(2-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148216(4-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-tetr...)
Affinity DataIC50:  0.75nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50090259((4-Benzyl-benzyl)-[2-((S)-2,2-dimethyl-1-methylcar...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of matrix metalloprotease-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50148223((R)-3-[4-(4-Fluoro-phenoxy)-benzenesulfonylamino]-...)
Affinity DataIC50:  0.770nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50194279(4-(2-(4-(4-(5-(2-methoxyethyl)-2,4,6-trioxo-hexahy...)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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