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Found 55 with Last Name = 'ewing' and Initial = 'fe'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007692(8-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-bu...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048806(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM50096326(6-{(E)-2-[3-(2-Chloro-phenyl)-6-fluoro-4-oxo-3,4-d...)
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048807(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001885((risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048804(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048805(5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048802(5'-[2-(4-benzo[d]isothiazol-3-ylhexahydro-1-pyrazi...)
Affinity DataKi:  4.20nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048803(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)et...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048800(6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50048801(6-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-et...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM50096327((R)-3-(2-Chloro-phenyl)-2-[(E)-2-(6-diethylaminome...)
Affinity DataKi:  25nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  45nMAssay Description:In vitro ability of the compound to displace [3H]-ketanserin from 5-hydroxytryptamine 2A receptor in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM85710(CP-471236)
Affinity DataKi:  57nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-NPA from rat brain Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM85711(CP-471237)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 3(RAT)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM50048389(4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]in...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007558(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007563(1-Ethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-yl)-et...)
Affinity DataIC50:  2.90nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  3.10nMAssay Description:Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007559(5-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-1,3...)
Affinity DataIC50:  4.87nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007556(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007557(3,3-Dimethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-y...)
Affinity DataIC50:  6.90nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284130(CHEMBL122580 | [(2S,3S)-2-(3-Chloro-phenyl)-1-aza-...)
Affinity DataIC50:  9.20nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007562(4-{4-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-...)
Affinity DataIC50:  11nMAssay Description:Binding affinity to 5-hydroxytryptamine 1A receptor in the rat brain using [3H]-8-hydroxy-2-(di-n-propylamine)tetralin as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284129(CHEMBL166610 | [(2S,3S)-2-(3-Chloro-phenyl)-1-aza-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50222217(CHEMBL172323)
Affinity DataIC50:  23nMAssay Description:Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50222216(CHEMBL173438)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50222216(CHEMBL173438)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007559(5-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-1,3...)
Affinity DataIC50:  38nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403373(CHEMBL2115528)
Affinity DataIC50:  39nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007556(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  44nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007562(4-{4-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-...)
Affinity DataIC50:  72nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007565(4-{4-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007563(1-Ethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-yl)-et...)
Affinity DataIC50:  81.2nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007560(1-Naphthalen-1-yl-4-[2-(4-[1,2,3]thiadiazol-4-yl-p...)
Affinity DataIC50:  83nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007557(3,3-Dimethyl-5-[2-(4-naphthalen-1-yl-piperazin-1-y...)
Affinity DataIC50:  86nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007566(1-{2-[4-(2-Methyl-thiazol-4-yl)-phenyl]-ethyl}-4-n...)
Affinity DataIC50:  108nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007558(6-[2-(4-Naphthalen-1-yl-piperazin-1-yl)-ethyl]-3H-...)
Affinity DataIC50:  112nMAssay Description:Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284131((2-Methoxy-benzyl)-((2S,3S)-2-phenyl-1-aza-bicyclo...)
Affinity DataIC50:  140nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007564(CHEMBL55806 | Methyl-(4-{4-[2-(4-naphthalen-1-yl-p...)
Affinity DataIC50:  155nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50007561(5-Methyl-4-{4-[2-(4-naphthalen-1-yl-piperazin-1-yl...)
Affinity DataIC50:  159nMAssay Description:Binding affinity to dopamine receptor D2 in the rat brain using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284136((2-Methoxy-benzyl)-[(2S,3S)-2-(3-methoxy-phenyl)-1...)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  172nMAssay Description:Compound was evaluated In vitro for its activity by binding to Dopamine receptor D2 in the rat brain using [3H]-NPA as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284133((2-Chloro-benzyl)-[(2S,3S)-2-(3-chloro-phenyl)-1-a...)
Affinity DataIC50:  230nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284128(CHEMBL167066 | [(2S,3R)-2-(3-Chloro-phenyl)-1-aza-...)
Affinity DataIC50:  240nMAssay Description:Inhibitory concentration for displacement of [3H]-Substance P (SP) in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50222216(CHEMBL173438)
Affinity DataIC50:  350nMAssay Description:Inhibition of [3H]spiroperidol binding to rat striatal membrane using 0.5 nM ligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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