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Found 152 with Last Name = 'fang' and Initial = 'f'
TargetMethionine synthase(Homo sapiens (Human))
Peking University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  0nMAssay Description:Inhibition of human Cobalamin-dependent methionine synthase isolated from HL-60 cells using methyltetrahydrofolate as substrate incubated for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551259(CHEMBL4749200)
Affinity DataIC50:  1nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234994(CHEMBL4063211)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
LigandPNGBDBM50551257(CHEMBL4794028)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Anhui University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50551259(CHEMBL4749200)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551256(CHEMBL4748095)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50235015(CHEMBL4091089)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551255(CHEMBL4755258)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551258(CHEMBL4790789)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551260(CHEMBL4740174)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  11.1nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme

US Patent
LigandPNGBDBM172038(US10155002, Compound 44 | US10647700, Compound EPZ...)
Affinity DataIC50:  13.0nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50551248(CHEMBL4760138)
Affinity DataIC50:  13nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551254(CHEMBL4761067)
Affinity DataIC50:  15nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551249(CHEMBL4755983)
Affinity DataIC50:  16nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  20nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Perking University

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human DHFR using dihydrofolate as substrate after 15 mins in presence of NADPHMore data for this Ligand-Target Pair
LigandPNGBDBM50551261(CHEMBL4755644)
Affinity DataIC50:  38nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551247(CHEMBL4755649)
Affinity DataIC50:  43nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214679(US9284330, S29)
Affinity DataIC50:  45nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50551250(CHEMBL4789993)
Affinity DataIC50:  48nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  57nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Perking University

Curated by ChEMBL
LigandPNGBDBM50461747(CHEMBL4226361)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human DHFR using dihydrofolate as substrate after 15 mins in presence of NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50235007(CHEMBL4087758)
Affinity DataIC50:  87nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  91nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50390673(CHEMBL2070198)
Affinity DataIC50:  98nMAssay Description:Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Anhui University Of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50551248(CHEMBL4760138)
Affinity DataIC50:  113nMAssay Description:Inhibition of recombinant human full-length His-tagged p110gamma expressed in baculovirus expression system using PIP2 as substrate measured after 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214678(US9284330, S28)
Affinity DataIC50:  136nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50551259(CHEMBL4749200)
Affinity DataIC50:  174nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110beta/p85beta expressed in baculovirus expression system using PIP2 as substrate measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214677(US9284330, S27)
Affinity DataIC50:  178nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50390674(CHEMBL2070199)
Affinity DataIC50:  216nMAssay Description:Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551259(CHEMBL4749200)
Affinity DataIC50:  221nMAssay Description:Inhibition of human full-length recombinant N-terminal His-tagged PI3K p110alpha/p85alpha expressed in baculovirus expression system using PIP2 as su...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214669(US9284330, S19)
Affinity DataIC50:  333nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  370nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human thymidylate synthase by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234995(CHEMBL4105643)
Affinity DataIC50:  386nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551252(CHEMBL4795822)
Affinity DataIC50:  396nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50551262(CHEMBL4799836)
Affinity DataIC50:  406nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50234990(CHEMBL4062453)
Affinity DataIC50:  441nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50551253(CHEMBL4742899)
Affinity DataIC50:  444nMAssay Description:Inhibition of human full-length recombinant His-tagged PI3K p110delta/p85alpha expressed in baculovirus expression system using PIP2 as substrate mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214672(US9284330, S22)
Affinity DataIC50:  450nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50235003(CHEMBL4101298)
Affinity DataIC50:  478nMAssay Description:Inhibition of N-terminal His6-tagged full-length recombinant human NEK2 expressed in baculovirus infected sf21 cells using biotin labelled-STK-3 subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214668(US9284330, S18)
Affinity DataIC50:  504nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214673(US9284330, S23)
Affinity DataIC50:  540nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAcetylcholinesterase(Homo sapiens (Human))
Jiangsu Simovay Pharmaceutical

US Patent
LigandPNGBDBM214652(US9284330, S2)
Affinity DataIC50:  558nMAssay Description:Procedure: 48 Ml 1xReaction Buffer was initially added to each compound test well in the 96-well black plate arranged, followed by addition of 2 Ml 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50390670(CHEMBL2070191)
Affinity DataIC50:  570nMAssay Description:Inhibition of EGFR in human A431 cell lysate using tyrosine/glutamic acid polymer as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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