Affinity DataKi: 0.400nM ΔG°: -53.6kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -53.1kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -51.4kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -47.9kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 170nMAssay Description:Binding affinity to syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM ΔG°: -33.8kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 1.83E+3nM ΔG°: -32.7kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.80E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.94E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataKi: 4.40E+4nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 8.45E+4nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 9.54E+4nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.03E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.07E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
Affinity DataKi: 1.10E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.22E+5nMAssay Description:Uncompetitive inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Lineweaver-Burk ...More data for this Ligand-Target Pair
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataKi: 1.78E+5nMAssay Description:Mixed noncompetitive type inhibition of soybean LOX-1 using linoleic acid as substrate preincubated for 5 mins followed by substrate addition by Line...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of syntenin-PDZ1-2 domain (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 5 mins by fluorescence polarization assa...More data for this Ligand-Target Pair
Affinity DataIC50: 7.51nMpH: 7.5 T: 2°CAssay Description:For the assay, compounds or nonbiotinylated H3(23-34) peptide were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMT: 2°CAssay Description:IC50 values were determined for compounds A-395 and A-395N at 75 nM of EZH2 trimeric complex (EZH2-EED-SUZ12), 3 μM of human nucleosome and 1 ...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 550nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+3nMpH: 7.5 T: 2°CAssay Description:For the assay, compounds or nonbiotinylated H3(23-34) peptide were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.03E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.52E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Universidade Do Porto
Curated by ChEMBL
Universidade Do Porto
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of 5-LOX-mediated LTB4 production in human neutrophils using arachidonic acid as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.36E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.43E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human liver FBP1 incubated for 5 mins by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9.46E+3nMpH: 7.8 T: 2°CAssay Description:The effect of 2-styrylchromone 1-3 on xanthine oxidase activity was evaluated by measuring the formation of uric acid from xanthine in a double beam ...More data for this Ligand-Target Pair