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Found 114 with Last Name = 'finley' and Initial = 'j'
TargetNeuraminidase(Influenza B virus (B/Lee/40))
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM4707(3-(2,2-diaminoimino)-4-methylcarboxamidobenzoate |...)
Affinity DataKi:  2.5nMAssay Description:In vitro inhibitory activity of the compound against B/Lee/40 Influenza B Neuraminidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483746(CHEMBL1770758)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483760(CHEMBL1770893)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483742(CHEMBL1770898)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483743(CHEMBL1770899)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483743(CHEMBL1770899)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483760(CHEMBL1770893)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483756(CHEMBL1770885)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483756(CHEMBL1770885)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
University Of Alabama At Birmingham

LigandPNGBDBM5266((2S,3S,4R)-4-carbamimidamido-2-(dipropylcarbamoyl)...)
Affinity DataIC50:  1nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483742(CHEMBL1770898)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483759(CHEMBL1770760)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483759(CHEMBL1770760)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483753(CHEMBL1770897)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483746(CHEMBL1770758)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483755(CHEMBL1770761)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483736(CHEMBL1770888)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483754(CHEMBL1770759)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483770(CHEMBL1770911)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483753(CHEMBL1770897)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483775(CHEMBL1770912)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483747(CHEMBL1770883)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483752(CHEMBL1770159)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza B virus (B/Lee/40))
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM5265((2S,3S,4R)-4-carbamimidamido-3-acetamido-2-[(1R,2S...)
Affinity DataIC50:  4nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483765(CHEMBL1770910)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483750(CHEMBL1770887)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483771(CHEMBL1770914)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483752(CHEMBL1770159)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483773(CHEMBL1770917)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuraminidase(Influenza A virus (A/Singapore/1/57(H2N2)))
University Of Alabama At Birmingham

LigandPNGBDBM5265((2S,3S,4R)-4-carbamimidamido-3-acetamido-2-[(1R,2S...)
Affinity DataIC50:  5nMpH: 6.5 T: 2°CAssay Description:A standard fluorimetric assay was used to measure influenza virus neuraminidase activity. The substrate 2 -(4-methylumbelliferyl)-alpha-D-acetylneura...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483754(CHEMBL1770759)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483765(CHEMBL1770910)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483772(CHEMBL1770915)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483750(CHEMBL1770887)
Affinity DataIC50:  7nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483749(CHEMBL1770886)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483740(CHEMBL1770895)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483738(CHEMBL1770891)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483764(CHEMBL1770907)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483748(CHEMBL1770884)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483757(CHEMBL1770890)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483736(CHEMBL1770888)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483764(CHEMBL1770907)
Affinity DataIC50:  12nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483749(CHEMBL1770886)
Affinity DataIC50:  13nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483755(CHEMBL1770761)
Affinity DataIC50:  15nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483777(CHEMBL1770913)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483774(CHEMBL1770909)
Affinity DataIC50:  19nMAssay Description:Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483774(CHEMBL1770909)
Affinity DataIC50:  20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483747(CHEMBL1770883)
Affinity DataIC50:  20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50483737(CHEMBL1770889)
Affinity DataIC50:  22nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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