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Found 2637 with Last Name = 'fleck' and Initial = 'b'
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [12]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(CHEMBL236521 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224184(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221119(CHEMBL236521 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50224184(1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity at mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221109((R)-2-amino-N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophe...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity to mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214682(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214688(1-{4-[(1R)-2-(amino-3-methylbutyl)-6-fluorophenyl]...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261229(1-{2-[(1S)-((2R)-Aminopropionamido)-2-methylpropyl...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221114(1-((R)-1-(4-(2-((S)-1-(3-aminopropylamino)-3-methy...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  0.940nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221133(1-((R)-1-(4-(2-((S)-1-(3-aminopropylamino)-3-methy...)
Affinity DataKi:  0.950nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221128(CHEMBL412023 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...)
Affinity DataKi:  1nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214704(1-{4-[(1S)-2-(amino-3-methylbutyl)-4-fluorophenyl]...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221120(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity at rat MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221143(1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...)
Affinity DataKi:  1nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50373508(CHEMBL404549)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50235751(CHEMBL255007 | {4-[2-((S)-1-amino-2-methyl-propyl)...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125]NDPMSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261228(1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221131(3-amino-N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50119366((R)-N-((R)-3-(4-chlorophenyl)-1-(4-cyclohexyl-4-((...)
Affinity DataKi:  1.20nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50261231(1-{2-[(1S)-(Azetidine-3-carboxamido)-2-methylpropy...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166520(1-Cyclopentyl-3-[(R)-1-(2,4-dichloro-benzyl)-2-oxo...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166533(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50373512(CHEMBL272538)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50373512(CHEMBL272538)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]NDP-MSH from human MC4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221141(CHEMBL397583 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221145(1-((R)-1-(4-(2-((S)-1-(3-aminopropylamino)-3-methy...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166523(CHEMBL195110 | Pyrrolidine-1-carboxylic acid [(R)-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221115(1-((R)-1-(4-(2-((S)-1-((2-aminoethyl)(methyl)amino...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221121(CHEMBL397584 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50186909((R)-N-(1-(4-(2-((2-methoxyphenethylamino)methyl)ph...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245535(CHEMBL487044 | N-((R)-1-(4-(2-(1-amino-3-methylbut...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166544(1-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214695(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50214689(1-{4-[(1S)-2-(1-amino-3-methylbutyl)-4-trifluorome...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]NDP-MSH from MC4R receptor in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50158484((R)-3-amino-N-(3-(2,4-dichlorophenyl)-1-oxo-1-(4-(...)
Affinity DataKi:  1.80nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225593((4-(1-((2-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [12]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221125(3-amino-N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50245534(2-amino-N-((R)-1-(4-(2-(1-amino-3-methylbutyl)phen...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50221127(3-amino-N-((S)-1-(2-(4-((R)-3-(2,4-dichlorophenyl)...)
Affinity DataKi:  2nMAssay Description:Binding affinity at human MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166534(4-Amino-N-[(R)-1-(2,4-dichloro-benzyl)-2-oxo-2-(4-...)
Affinity DataKi:  2nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50166525(3-[(R)-1-(2,4-Dichloro-benzyl)-2-oxo-2-(4-{2-[(2-t...)
Affinity DataKi:  2nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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