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Found 67 with Last Name = 'fontanella' and Initial = 'l'
TargetProstaglandin G/H synthase 1(RAT)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172479((S)-FLURBIPROFEN | CHEMBL435298)
Affinity DataIC50:  30nMAssay Description:Concentration required to inhibit cyclooxygenase-1 in rat bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(RAT)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  170nMAssay Description:Concentration required to inhibit cyclooxygenase-1 in rat bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172479((S)-FLURBIPROFEN | CHEMBL435298)
Affinity DataIC50:  910nMAssay Description:Concentration required to inhibit cyclooxygenase-2 in human bloodMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172466(2-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  4.70E+3nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  5.30E+3nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172465(1-(4,2',2''-Trifluoro-[1,1';4',1'']terphenyl-4''-y...)
Affinity DataIC50:  7.00E+3nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172472(2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propiona...)
Affinity DataIC50:  1.20E+4nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50:  1.40E+4nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  1.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172468(1-(4-Benzo[b]thiophen-3-yl-3-fluoro-phenyl)-cyclop...)
Affinity DataIC50:  1.90E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172462(1-[2-Fluoro-4'-(4-trifluoromethyl-cyclohexyloxy)-b...)
Affinity DataIC50:  2.00E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172462(1-[2-Fluoro-4'-(4-trifluoromethyl-cyclohexyloxy)-b...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172478(2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propioni...)
Affinity DataIC50:  2.00E+4nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172475(2-(4'-Cyclohexyl-2-fluoro-biphenyl-4-yl)-propionic...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  2.15E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172463(1-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-cycl...)
Affinity DataIC50:  2.20E+4nMAssay Description:Concentration required to inhibit A beta 40 peptide 100 umMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50:  2.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  2.60E+4nMAssay Description:Interaction with human cytochrome P450 isoform 1A2 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  2.70E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172481(2-(4'-Cyclohexyl-2-fluoro-biphenyl-4-yl)-2-methyl-...)
Affinity DataIC50:  2.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  3.00E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2D6 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172460(1-[2-Fluoro-4'-(3,3,5,5-tetramethyl-cyclohexyloxy)...)
Affinity DataIC50:  3.30E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50:  3.36E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172466(2-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172459(1-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  3.50E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172465(1-(4,2',2''-Trifluoro-[1,1';4',1'']terphenyl-4''-y...)
Affinity DataIC50:  3.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50:  3.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C9 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172474(2-(4'-Cyclohexyloxy-2-fluoro-biphenyl-4-yl)-propio...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(RAT)
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172473((-)-(2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid |...)
Affinity DataIC50:  4.40E+4nMAssay Description:Concentration required to inhibit cyclooxygenase-1 in rat bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172467(1-[4'-(4,4-Dimethyl-cyclohexyl)-2-fluoro-biphenyl-...)
Affinity DataIC50:  4.60E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172475(2-(4'-Cyclohexyl-2-fluoro-biphenyl-4-yl)-propionic...)
Affinity DataIC50:  4.60E+4nMAssay Description:Concentration required to inhibit A beta 40 peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172465(1-(4,2',2''-Trifluoro-[1,1';4',1'']terphenyl-4''-y...)
Affinity DataIC50:  4.60E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172482(1-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-cyclopro...)
Affinity DataIC50:  4.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172465(1-(4,2',2''-Trifluoro-[1,1';4',1'']terphenyl-4''-y...)
Affinity DataIC50:  5.79E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50:  5.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172466(2-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  5.80E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172477(1-(4'-Cyclohexyl-2-fluoro-biphenyl-4-yl)-cycloprop...)
Affinity DataIC50:  5.90E+4nMAssay Description:Inhibition of cytochrome P450 3A4 at 100 uM; activation observedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172481(2-(4'-Cyclohexyl-2-fluoro-biphenyl-4-yl)-2-methyl-...)
Affinity DataIC50:  5.90E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172472(2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propiona...)
Affinity DataIC50:  6.40E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172476(2-(2-Fluoro-4'-methoxy-biphenyl-4-yl)-propionic ac...)
Affinity DataIC50:  6.70E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172485(2-(2-Fluoro-4'-trifluoromethyl-biphenyl-4-yl)-2-me...)
Affinity DataIC50:  7.06E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172461(1-(2',2''-Difluoro-4-hydroxy-[1,1';4',1'']terpheny...)
Affinity DataIC50:  7.40E+4nMAssay Description:Interaction with human cytochrome P450 isoform 2C19 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172466(2-(2-Fluoro-4''-hydroxy-[1,1';4',1'']terphenyl-4-y...)
Affinity DataIC50:  7.40E+4nMAssay Description:Interaction with human cytochrome P450 isoform 3A4 expressed in baculovirus-insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172483(2-(3',4'-Dichloro-2-fluoro-biphenyl-4-yl)-propioni...)
Affinity DataIC50:  7.50E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Chiesi Farmaceutici

Curated by ChEMBL
LigandPNGBDBM50172469(2-(3',5'-Dichloro-2-fluoro-biphenyl-4-yl)-propioni...)
Affinity DataIC50:  7.70E+4nMAssay Description:Inhibitory concentration against beta-amyloid-42 (Abeta42) secretion was evaluated in human neuroglioma cells (H4-APP695NL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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