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Found 171 with Last Name = 'foubister' and Initial = 'a'
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291312(4-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  2nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  6nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291315(5-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  8nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291311(6-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  20nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291316(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  20nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi:  43nMAssay Description:Tested for its inhibitory activity against human microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291317(CHEMBL154472 | [3-Allyl-4-(3-hydroxy-1-aza-bicyclo...)
Affinity DataKi:  100nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291318(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi: >250nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291313(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi: >250nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291319(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi: >250nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291314(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataKi: >250nMAssay Description:Tested for its inhibitory activity against rat microsomal quinuclidine squalene synthase (SQS)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029174(CHEMBL131973 | N-(1-methylethyl)-3-[(3-prop-2-en-1...)
Affinity DataIC50:  0.00400nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029177(CHEMBL134337 | Propionic acid 3-allyl-4-(3-isoprop...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029166(Acetaldehyde O-[3-allyl-4-(3-isopropylamino-propox...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029159(CHEMBL132881 | [3-(2-Allyl-4-butoxy-phenoxy)-propy...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029171(CHEMBL341371 | N-[3-Benzyl-4-(3-isopropylamino-pro...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029179(1-[3-Allyl-4-(3-isopropylamino-propoxy)-phenyl]-bu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052343(3-Biphenyl-4-ylethynyl-1-aza-bicyclo[2.2.2]octan-3...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029163(CHEMBL340992 | Propionic acid 4-(3-isopropylamino-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052350(3-((E)-2-Biphenyl-4-yl-vinyl)-1-aza-bicyclo[2.2.2]...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029170(1-[3-Allyl-4-(2-hydroxy-3-isopropylamino-propoxy)-...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052342(3-(2-Biphenyl-4-yl-ethyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029161(CHEMBL433864 | N-{3-Allyl-4-[3-(isopropyl-methyl-a...)
Affinity DataIC50:  5nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052353(3-(4-Benzothiazol-2-yl-phenyl)-1-aza-bicyclo[2.2.2...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50075719(3-[3-Allyl-4-(3-hydroxy-1-aza-bicyclo[2.2.2]oct-3-...)
Affinity DataIC50:  6nMAssay Description:Compound was measured for the inhibition of rat microsomal squalene synthase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052355(3-(2-Biphenyl-4-yl-ethyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  7nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052377(3-(Biphenyl-4-ylsulfanylmethyl)-1-aza-bicyclo[2.2....)
Affinity DataIC50:  8nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034758((E)-7-(3-{4-[(2S,4S,5R)-5-((Z)-5-Carboxy-pent-2-en...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034767((E)-7-(4-{5-[(2S,4S,5R)-5-((Z)-5-Carboxy-pent-2-en...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034762((E)-7-(4-{6-[(2S,4S,5R)-5-((Z)-5-Carboxy-pent-2-en...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153821(3-Fluoro-N-{4-methyl-3-[4-(pyridin-4-ylmethoxy)-be...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153848(CHEMBL184012 | N-{4-Methyl-3-[4-(pyridin-2-ylmetho...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153832(3-Fluoro-N-{4-methyl-3-[4-(thiazol-4-ylmethoxy)-be...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153846(4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...)
Affinity DataIC50:  10nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052376(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octane | CHEMB...)
Affinity DataIC50:  11nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50029172(CHEMBL131930 | [3-(2-Benzyl-phenoxy)-propyl]-isopr...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052358(3-(Biphenyl-4-yloxymethyl)-1-aza-bicyclo[2.2.2]oct...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052351(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052351(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Affinity DataIC50:  16nMAssay Description:Compound was measured for the inhibition of rat microsomal squalene synthase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052366(3-(4'-Fluoro-biphenyl-4-yl)-1-aza-bicyclo[2.2.2]oc...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052352(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CH...)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50010960((E)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50034750((E)-7-(4-{4-[(2S,4S,5R)-5-((Z)-5-Carboxy-pent-2-en...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against human microsomal thromboxane synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50288601((Z)-6-[(2S,4S,5R)-2-(4-Cyano-phenyl)-4-pyridin-3-y...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for thromboxane TXA2 synthase inhibitory activity using human plateletMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153845(4-methyl-3-[4-(2-methyl-1,3-thiazol-4-ylmethoxy)ph...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153840(4-methyl-1-[3-(1,4-oxazinan-4-yl)phenylcarboxamido...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153847(3-Fluoro-N-{4-methyl-3-[4-(pyridin-2-ylmethoxy)-be...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50153833(CHEMBL365688 | N-{4-Methyl-3-[4-(pyridin-2-ylmetho...)
Affinity DataIC50:  20nMAssay Description:Concentration required to inhibit human mitogen activated protein kinase p38 activity More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50052367(3-(Biphenyl-4-ylsulfanyl)-1-aza-bicyclo[2.2.2]octa...)
Affinity DataIC50:  21nMAssay Description:In vitro inhibition against rat microsomal squalene synthase (SS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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