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Found 336 with Last Name = 'fragai' and Initial = 'm'
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.240nMpH: 6.8Assay Description:Inhibition of human MMP12 catalytic domain (98 to 266) at pH 6.8 by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50265078((4S)-5-amino-4-((2S)-2-((2S)-3-((4-bromophenyl)(hy...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426080(CHEMBL2316257)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434226(CHEMBL2385483)
Affinity DataKi:  1nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP-13 catalytic domain (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434222(CHEMBL2385487)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50294120(2-(biphenyl-4-ylsulfonamido)-N-hydroxyacetamide | ...)
Affinity DataKi:  2nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332952(CHEMBL1233772 | N-hydroxy-2-(N-(2-hydroxyethyl)bip...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332947((S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulf...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332952(CHEMBL1233772 | N-hydroxy-2-(N-(2-hydroxyethyl)bip...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434213(CHEMBL2385489)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434224(CHEMBL2385485)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  5.70nMAssay Description:Inhibition of human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434221(CHEMBL2385490)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  6nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434223(CHEMBL2385486)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332948((R)-2-(N-((S)-2,3-dihydroxypropyl)-4-methoxyphenyl...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332947((S)-2-(N-(2,3-dihydroxypropyl)-4-methoxyphenylsulf...)
Affinity DataKi:  8nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM13080(CGS 27023A Analog 3 | N-hydroxy-2-[(4-methoxybenze...)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332949((R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamido)pr...)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434219(CHEMBL2385492)
Affinity DataKi:  9nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  9.10nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434227(CHEMBL2385482)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434225(CHEMBL2385484)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332950((2R,3R)-N,3-dihydroxy-2-(4-methoxyphenylsulfonamid...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetELAV-like protein 1(Homo sapiens (Human))
Institute Of Molecular Science And Technology (Istm)

Curated by ChEMBL
LigandPNGBDBM50270003(CHEMBL4075458)
Affinity DataKi:  13nMAssay Description:Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332946(CHEMBL1234724 | N-hydroxy-2-(N-(2-hydroxyethyl)-4-...)
Affinity DataKi:  13nMAssay Description:Inhibition of MMP8 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  14nMAssay Description:Inhibition of MMP-12 catalytic domain (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate measured...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50332945(CHEMBL1232074 | N-hydroxy-2-(4-methoxy-N-(2-((2R,3...)
Affinity DataKi:  14.3nMAssay Description:Inhibition of MMP12 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434214(CHEMBL2385488)
Affinity DataKi:  15nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426079(CHEMBL2316258)
Affinity DataKi:  15nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetELAV-like protein 1(Homo sapiens (Human))
Institute Of Molecular Science And Technology (Istm)

Curated by ChEMBL
LigandPNGBDBM50269995(CHEMBL4064932)
Affinity DataKi:  15nMAssay Description:Binding affinity to human full length recombinant His-tagged HuR expressed in Escherichia coli Rosetta DH5alpha assessed as inhibition of interaction...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434215(CHEMBL2385481)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP-2 (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50426081(CHEMBL2316256)
Affinity DataKi:  16nMAssay Description:Binding affinity to human MMP12 catalytic domain (98 to 266) by isothermal titration calorimetryMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Protera

Curated by ChEMBL
LigandPNGBDBM50332953((S)-2-(N-(2,3-dihydroxypropyl)biphenyl-4-ylsulfona...)
Affinity DataKi:  18nMAssay Description:Inhibition of MMP13 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant MMP-9 catalytic domain (112 to 445 residues) expressed in Escherichia coli assessed as inhibition of hydrolysis of Mc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM11328(CHEMBL83508 | Hydroxamate 9 | N-hydroxy-2-[(4-meth...)
Affinity DataKi:  20nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50434216(CHEMBL2385480)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP12 (unknown origin)-mediated Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Cea

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP-12 catalytic domain (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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