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Found 1307 with Last Name = 'gao' and Initial = 'm'
TargetCollagenase 3(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268316(CHEMBL4080186)
Affinity DataKi:  0.470nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268309(CHEMBL4088060)
Affinity DataKi:  0.590nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268309(CHEMBL4088060)
Affinity DataKi:  0.710nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of APMA activated recombinant human full length MMP2 expressed in mouse cells using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50510071(CHEMBL4541082)
Affinity DataKi:  1.90nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50510072(CHEMBL4435339)
Affinity DataKi:  2.5nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human MMP8 catalytic domain (Phe99 to Gln269 residues) expressed in Escherichia coli using McaKPLGL-Dpa-AR-NH2 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50416603(CHEMBL1222883)
Affinity DataKi:  3.10nMAssay Description:Competitive displacement of [11C]GSK1482160 from human recombinant P2X7 receptor expressed in HEK293 cell membranes incubated for 30 mins by scintill...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268317(CHEMBL4076356)
Affinity DataKi:  3.30nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50041978(CHEMBL3134157)
Affinity DataKi:  3.60nMAssay Description:Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liqu...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]ketanserin from 5-HT2A receptor in human frontal cortex after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308541(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  5.40nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230401(CHEMBL4088079)
Affinity DataKi:  5.70nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308537(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  6.92nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230385(CHEMBL4103682)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230386(CHEMBL4059902)
Affinity DataKi:  7.70nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230398(CHEMBL4093905)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230369(CHEMBL4079379)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230372(CHEMBL4080203)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230411(RAC-IBIPINABANT | SLV-319)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308538(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  9.37nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant human MMP9 catalytic domain (Phe107 to Pro449 residues) expressed in Escherichia coli using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230414(CHEMBL4104443)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230377(CHEMBL4095928)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230370(CHEMBL4097409)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230406(CHEMBL4077774)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308539(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]raclopride from D2 receptor in human corpus striatum after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]mesulergine from 5-HT2C receptor in human frontal cortex after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230379(CHEMBL4085754)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230381(CHEMBL4068564)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230383(CHEMBL4092420)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230408(CHEMBL4076361)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230403(CHEMBL4082778)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268316(CHEMBL4080186)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant MMP-8 catalytic domain (99 to 269 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308546(2-Chloro-7-methoxy-8-pentyloxy-1-quinoline-3-carbo...)
Affinity DataKi:  23.8nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268317(CHEMBL4076356)
Affinity DataKi:  25nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230396(CHEMBL4089263)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230368(CHEMBL4089687)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230382(CHEMBL4098324)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50308540(7-Methoxy-2-oxo-8-pentyloxy-1,2-dihydroquinoline-3...)
Affinity DataKi:  27.9nMAssay Description:Displacement of [3H]CP55940 from CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230397(CHEMBL4095806)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230380(CHEMBL4091555)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230407(CHEMBL4070659)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50265157((6S,7S)-N-hydroxy-5-methyl-6-(4-(5-(trifluoromethy...)
Affinity DataKi:  30nMAssay Description:Inhibition of recombinant human MMP12 catalytic domain using Mca-PLGL-DpaAR-NH2 as substrate by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230371(CHEMBL4071282)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Notre Dame

Curated by ChEMBL
LigandPNGBDBM50268310(CHEMBL4069479)
Affinity DataKi:  36nMAssay Description:Inhibition of human recombinant MMP-13 catalytic domain (104 to 274 residues) expressed in Escherichia coli using fluorogenic Mca-KPLGL-Dpa-AR-NH2 as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine kinase 1(Homo sapiens (Human))
Virginia Tech

Curated by ChEMBL
LigandPNGBDBM50077147(CHEMBL3416846)
Affinity DataKi:  48nMAssay Description:Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liqu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism

Curated by ChEMBL
LigandPNGBDBM50230384(CHEMBL4066919)
Affinity DataKi:  48nMAssay Description:Displacement of [3H]CP55940 from mouse brain CB1R expressed in CHOK1 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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