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Found 84 with Last Name = 'georges' and Initial = 'g'
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24722(7,7,16-trimethyl-5,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24722(7,7,16-trimethyl-5,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50: <2nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24721(5-ethyl-7,7,16-trimethyl-5,11,14,15-tetraazapentac...)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24721(5-ethyl-7,7,16-trimethyl-5,11,14,15-tetraazapentac...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335329(2-(4-Fluorobenzyl)-4-(5-methyl-1H-pyrazol-3-ylamin...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335315(2-(Methyl-3-pyridine)-4-(5-methyl-1H-pyrazol-3-yla...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24720(5-methyl-3,4,17-triazatetracyclo[8.7.0.0^{2,6}.0^{...)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335332(4-(1H-Pyrazol-3-ylamino)-2-p-tolyl-2H-phthalazin-1...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335333(4-(5-Methyl-1H-pyrazol-3-ylamino)-2-m-tolyl-2H-pht...)
Affinity DataIC50:  24nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50249453(2-(2,5-difluorobenzyl)-4-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335331(2-(4-Methoxyphenyl)-4-(5-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50:  29nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335330(4-(5-Methyl-2H-pyrazole-3-ylamino)phenyl-2H-phthal...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335327(2-(4-Methoxybenzyl)-4-(5-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335323(2-Isopropyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-p...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335322(2-(3-Methoxybenzyl)-4-(5-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335334(2-(4-Fluorophenyl)-4-(5-methyl-1H-pyrazol-3-ylamin...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24720(5-methyl-3,4,17-triazatetracyclo[8.7.0.0^{2,6}.0^{...)
Affinity DataIC50:  42nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335336(2-(3,5-Difluorobenzyl)-4-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24714(5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{...)
Affinity DataIC50:  51nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335324(2-(4-Toluylsulfonate)-4-(5-methyl-1H-pyrazol-3-yla...)
Affinity DataIC50:  56nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335335(2-Benzyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phth...)
Affinity DataIC50:  65nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50249210(4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2,2,2-trifluo...)
Affinity DataIC50:  66nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335337(2-[2-(4-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-...)
Affinity DataIC50:  67nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24712(5-ethyl-7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-...)
Affinity DataIC50:  69nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50249420(4-(5-methyl-1H-pyrazol-3-ylamino)-2-(2-oxo-2-pheny...)
Affinity DataIC50:  71nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24723(5,5,16-trimethyl-7,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50:  72nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24723(5,5,16-trimethyl-7,11,14,15-tetraazapentacyclo[10....)
Affinity DataIC50:  86nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50249237(2-(4-chlorophenyl)-4-(5-methyl-1H-pyrazol-3-ylamin...)
Affinity DataIC50:  93nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335317(CHEMBL1651480 | N-{4-[1-Oxo-4-(1H-pyrazol-3-ylamin...)
Affinity DataIC50:  93nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335328(2-[2-(3-Methoxyphenyl)-2-oxoethyl]-4-(5-methyl-1H-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335340(4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(4-nitrobenzyl...)
Affinity DataIC50:  109nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24715(5-cyclopropyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335325(2-Isobutyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-ph...)
Affinity DataIC50:  115nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335320(4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(2-methylthiaz...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24712(5-ethyl-7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24711(7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-1H,5H,6H...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24711(7,7-dimethyl-2-(5-methyl-1H-pyrazol-3-yl)-1H,5H,6H...)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24714(5-methyl-3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{...)
Affinity DataIC50:  220nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335339(2-(4-tert-Butylphenyl)-4-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataIC50:  240nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335318(2-Methyl-4-(5-methyl-1H-pyrazol-3-ylamino)-2H-phth...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335321(2-(Methyl-4-pyridine)-4-(5-methyl-1H-pyrazol-3-yla...)
Affinity DataIC50:  270nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24713(1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole | 3,4,1...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24717(3,4,16-triazatetracyclo[7.7.0.0^{2,6}.0^{10,15}]he...)
Affinity DataIC50:  340nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Genentech

LigandPNGBDBM24718(2-(5-Methyl-1H-pyrazol-3-yl)-1H-indole | pyrazole-...)
Affinity DataIC50:  510nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335326(CHEMBL1651491 | N-(4-((4-(1H-pyrazol-3-ylamino)-1-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335319(4-(5-Methyl-1H-pyrazol-3-ylamino)-2H-phthalazin-1-...)
Affinity DataIC50:  650nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM50335338(4-(5-Methyl-1H-pyrazol-3-ylamino)-2-[2-oxo-2-(4-tr...)
Affinity DataIC50:  720nMAssay Description:Inhibition of Aurora A by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Genentech

LigandPNGBDBM24719(13-methyl-8,11,12-triazatetracyclo[7.6.0.0^{2,7}.0...)
Affinity DataIC50:  870nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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