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Found 523 with Last Name = 'georgi' and Initial = 'k'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50151865(CHEMBL172 | MEFLOQUINE)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Serono

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Serono

Curated by ChEMBL
LigandPNGBDBM79214(1-[1,3-bis(chloranyl)-6-(trifluoromethyl)phenanthr...)
Affinity DataKi:  7.50E+3nMAssay Description:Inhibition of human ERG expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356214(CHEMBL1910471)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356215(CHEMBL1910473)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356209(CHEMBL1910466)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356210(CHEMBL1910467)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356208(CHEMBL1910465)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-enolase(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50590126(CHEMBL5185604)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of ENO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356222(CHEMBL1910648)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356218(CHEMBL1910476)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356206(CHEMBL1910459)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356216(CHEMBL1910474)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356221(CHEMBL1910647)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356219(CHEMBL1910649)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356220(CHEMBL1910650)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356203(CHEMBL1910472)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574274(CHEMBL4860970)
Affinity DataIC50:  4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM117012(US8637532, 739)
Affinity DataIC50:  4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574277(CHEMBL4871106)
Affinity DataIC50:  4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24047((2R)-3-methyl-2-[(4-{4-[(3-methyl-1-benzofuran-2-y...)
Affinity DataIC50:  4.40nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356213(CHEMBL1910470)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356207(CHEMBL1910460)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356204(CHEMBL1910453)
Affinity DataIC50:  5.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574276(CHEMBL4846712)
Affinity DataIC50:  6nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574271(CHEMBL4876446)
Affinity DataIC50:  6nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574278(CHEMBL4854144)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-enolase(Homo sapiens (Human))
University Of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50590127(CHEMBL5187779)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of ENO1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50258875((R)-2-(4'-((4-(4-fluorobenzoyl)phenoxy)methyl)biph...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50073190(CHEMBL3408213 | US11471446, Compound DBA-11)
Affinity DataIC50:  7nMAssay Description:Inhibition of ligand-induced WNT3A signaling in human PA-1 cells harboring TCF preincubated for 6 hrs before ligand addition measured after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356205(CHEMBL1910458)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356242(CHEMBL1910461)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574275(CHEMBL4856439)
Affinity DataIC50:  10nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356217(CHEMBL1910475)
Affinity DataIC50:  12nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574270(CHEMBL4855657)
Affinity DataIC50:  14nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50258917((R)-2-(4'-((4-(cyclohexanecarbonyl)phenoxy)methyl)...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM116525(US8637532, 211)
Affinity DataIC50:  15nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CK2alpha (unknown origin) (2 to 329 residues) expressed in Escherichia coli BL21 (DE3) using RRRADDSDDDD substrate incubated for 40 min...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50574273(CHEMBL4871853)
Affinity DataIC50:  17nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target2-Hydroxyacid oxidase 1(Homo sapiens (Human))
X-Chem

Curated by ChEMBL
LigandPNGBDBM50581744(CHEMBL5086346)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant HAO1 assessed as detecting hydrogen peroxide using glycolic acid as substrate preincubated for 30 min followed by sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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