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Found 193 with Last Name = 'guichou' and Initial = 'jf'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | US11420968, Example ABT-199 | Venetoclax)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of BCL2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546262(CHEMBL4751195)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi: <0.5nMAssay Description:Inhibition of BCL2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM13954(3-({5-[(2S)-3-{4-[(2-carboxyphenyl)amidoformic aci...)
Affinity DataKi:  22nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate measured every 30 secs for 15 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546260(CHEMBL4782926)
Affinity DataKi:  25nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50462575(CHEMBL4238121)
Affinity DataKi:  29nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCaspase-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM220(5-{[(4-{[(2S)-1-carboxy-3-oxopropan-2-yl]carbamoyl...)
Affinity DataKi:  200nMAssay Description:Inhibition of recombinant human caspase 3 using Ac-Asp-Glu-Val-Asp-AFC as substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546250(CHEMBL4754689)
Affinity DataKi:  1.90E+3nMAssay Description:Displacement of biotin-labelled geldanamycin from human HSP90 (D9 to E236 residues) incubated for 3 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546251(CHEMBL4783360)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human HSP90 (D9 to E236 residues) by fluorescence spectroscopyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM13990(5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbony...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate measured every 30 secs for 15 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546261(CHEMBL234378)
Affinity DataKi:  1.20E+5nMAssay Description:Inhibition of caspase-3 (unknown origin) using Ac-DEVD-AMCA as substrate incubated for 5 mins by Dixon plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50232690(4-Aminomethyl-Benzamidine | CHEMBL187301)
Affinity DataKi:  6.80E+5nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50514418(CHEMBL4572188)
Affinity DataKi:  5.50E+6nMAssay Description:Inhibition of human factor 10a using Boc-Leu-Gly-Arg-AMC as fluorogenic substrate measured after 10 mins by spectrofluorimetryMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM9047(Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50520331(CHEMBL4445137)
Affinity DataIC50: <1nMAssay Description:Inhibition of human NMT1 by fluorescence methodMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181474(1-(3-benzyloxy-pyridin-2-yl)-3-(4-nitro-phenyl)-ur...)
Affinity DataIC50:  14nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50149219(3-(3'-Cyanomethyl-biphenyl-4-yloxy)-N-hydroxy-prop...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MMP3 (unknown origin) using Ac-Pro-Leu-Gly-[2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181489(4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  20nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitinase B(Serratia marcescens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50462584(CHEMBL4245260)
Affinity DataIC50:  22nMAssay Description:Inhibition of Serratia marcescens chitinase BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50504620(GW280670X)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin) using histone H1 as substrate by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothiapepsin(Cryphonectria parasitica)
Universit£

Curated by ChEMBL
LigandPNGBDBM50546276(CHEMBL4743297)
Affinity DataIC50:  54nMAssay Description:Inhibition of Endothia parasitica endothiapepsin using Abz-Thr-Ile-Nle-p-nitro-Phe-Gln-Arg-NH2 as substrate by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181493(4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzenesul...)
Affinity DataIC50:  60nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181475(1-(3-benzyloxy-pyridin-2-yl)-3-(3-nitro-phenyl)-ur...)
Affinity DataIC50:  60nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546256(CHEMBL4793660)
Affinity DataIC50:  64nMAssay Description:Inhibition of c-Src (unknown origin) using biotin-KVEKIGEGTYGVVYK as substrate by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181496(3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  71nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50181873(CHEMBL383229 | N-[4-(4,4-dimethylpiperidin-1-yl)be...)
Affinity DataIC50:  79nMAssay Description:Inhibition of FITC-labeled Bak BH3 peptide binding to His6-tagged GST-fused Bcl-xL (unknown origin) expressed in Escherichia coli BL21 preincubated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase B(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546259(CHEMBL4092230)
Affinity DataIC50:  80nMAssay Description:Inhibition of C-terminal His6-tagged CypB (unknown origin) expressed in Escherichia coli C41(DE3) using Suc-Ala-Ala-Cis-Pro-Phe-pNA as substrate by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50546259(CHEMBL4092230)
Affinity DataIC50:  100nMAssay Description:Inhibition of C-terminal His6-tagged CypA (unknown origin) expressed in Escherichia coli C41(DE3) using Suc-Ala-Ala-Cis-Pro-Phe-pNA as substrate by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181491(4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  140nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181483(1-(3-benzyloxypyridin-2-yl)-3-(3-trifluoromethylph...)
Affinity DataIC50:  303nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181495(1-(3-benzyloxypyridin-2-yl)-3-(3-chlorophenyl)-ure...)
Affinity DataIC50:  316nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181492(4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-N-methyl-b...)
Affinity DataIC50:  320nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Lebanese University

Curated by ChEMBL
LigandPNGBDBM50161326(CHEMBL3787023)
Affinity DataIC50:  324nMAssay Description:Inhibition of human recombinant GST tagged IKK2 expressed in baculovirus using Ser/Thr05 peptide as substrate after 60 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181479(3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide ...)
Affinity DataIC50:  361nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181494(1-(3-benzyloxy-pyridin-2-yl)-3-(2,4-difluoro-pheny...)
Affinity DataIC50:  458nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181487(1-(3-benzyloxy-pyridin-2-yl)-3-(4-trifluoromethyl-...)
Affinity DataIC50:  499nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50546269(CHEMBL4761368)
Affinity DataIC50:  510nMAssay Description:Inhibition of HDAC8 (unknown origin) using acetylated lysine as substrate incubated for 20 mins by Lineweaver-Burk double-reciprocal plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181481(CHEMBL199550 | {3-[3-(3-benzyloxy-pyridin-2-yl)-ur...)
Affinity DataIC50:  528nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Lebanese University

Curated by ChEMBL
LigandPNGBDBM50161273(CHEMBL3787275)
Affinity DataIC50:  579nMAssay Description:Inhibition of human recombinant GST tagged IKK2 expressed in baculovirus using Ser/Thr05 peptide as substrate after 60 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitinase B(Serratia marcescens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50546270(CHEMBL4754642)
Affinity DataIC50:  580nMAssay Description:Inhibition of Serratia marcescens chitinase BMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181478(1-(3-benzyloxy-pyridin-2-yl)-3-(2-chloro-phenyl)-u...)
Affinity DataIC50:  592nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  600nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazineMore data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181480(1-(3-benzyloxy-pyridin-2-yl)-3-(4-chloro-phenyl)-u...)
Affinity DataIC50:  640nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Lebanese University

Curated by ChEMBL
LigandPNGBDBM25919(BMS-345541 | BMS345541 | CHEMBL471496 | N-(2-amino...)
Affinity DataIC50:  644nMAssay Description:Inhibition of human recombinant GST tagged IKK2 expressed in baculovirus using Ser/Thr05 peptide as substrate after 60 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181482(3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  748nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181486(1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea | CHEMB...)
Affinity DataIC50:  754nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Lebanese University

Curated by ChEMBL
LigandPNGBDBM50161329(CHEMBL3786867)
Affinity DataIC50:  773nMAssay Description:Inhibition of human recombinant GST tagged IKK2 expressed in baculovirus using Ser/Thr05 peptide as substrate after 60 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181477(4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide ...)
Affinity DataIC50:  810nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181488(2-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  880nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
University Of Montpellier

Curated by ChEMBL
LigandPNGBDBM50181484(3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzoic ac...)
Affinity DataIC50:  951nMAssay Description:Inhibition of isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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