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Found 93 with Last Name = 'handa' and Initial = 'c'
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051232(8-(4-Fluoro-benzyl)-2-furan-2-yl-8H-pyrazolo[4,3-e...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to rat A2A adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  5.30nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051226(7-(4-Fluoro-benzyl)-2-furan-2-yl-7H-pyrazolo[4,3-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity to rat A2A adenosine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254384(CHEMBL4079067)
Affinity DataKi:  40nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50207816(CHEMBL273094 | N-(2-Amino-ethyl)-2-[4-(2,6-dioxo-1...)
Affinity DataKi:  50nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  481nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50254363(CHEMBL4103324)
Affinity DataKi:  1.52E+3nMAssay Description:Displacement of MRS5346 from C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pich...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of wild type human N-terminal GST-fusion tagged TRKB kinase domain (456 to 822 residues) expressed in baculovirus expression system by HTR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of wild type human His-tagged TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of TRKA E735A mutant (unknown origin) expressed in baculovirus infected sf9 cells assessed as kinase domain dimerization by HTRF assayMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  6nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50392788(CHEMBL457614)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50198370(CHEMBL223873 | N-(2,6-dimethyl-phenyl)-5-phenylimi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50:  85nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50:  119nMAssay Description:Inhibition of juxtamembrane region containing recombinant human N-terminal His6-tagged/GST-tagged TrkA (473 to 796 residues) expressed in baculovirus...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50:  132nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50:  142nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50510995(CHEMBL4556229)
Affinity DataIC50:  199nMAssay Description:Inhibition of wild type human His-tagged TRKA kinase domain (441 to 796 residues) expressed in baculovirus expression system by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50246553(CHEMBL462228 | N-(2-chlorophenyl)-5-phenylimidazo[...)
Affinity DataIC50:  220nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50022672(CHEMBL3298266)
Affinity DataIC50:  287nMAssay Description:Inhibition of juxtamembrane region deficient recombinant human N-terminal His6-tagged/GST-tagged TrkA (498 to 796 residues) expressed in baculovirus ...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant human TrkB expressed in DHFR deficient CHO cells assessed as inhibition of human brain-derived neurotrophic factor-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of recombinant human TrkC expressed in DHFR deficient CHO cells assessed as inhibition of human neurotrophin-3-induced calcium influx by F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435857(CHEMBL2393579)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435854(CHEMBL2393583)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435849(CHEMBL2391046)
Affinity DataIC50:  1.53E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435850(CHEMBL2391045)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435855(CHEMBL2393581)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435851(CHEMBL2391044)
Affinity DataIC50:  3.34E+4nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50232542(CHEMBL4090531 | US10323022, Example 135)
Affinity DataIC50:  3.72E+4nMAssay Description:Inhibition of recombinant human TrkA expressed in DHFR deficient CHO cells assessed as inhibition of human beta-nerve growth factor-induced calcium i...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Osaka Prefecture University

Curated by ChEMBL
LigandPNGBDBM50510995(CHEMBL4556229)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition of wild type human N-terminal GST-fusion tagged TRKB kinase domain (456 to 822 residues) expressed in baculovirus expression system by HTR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435853(CHEMBL2393584)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435856(CHEMBL2393580)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Mycobacterium tuberculosis)
Msd Animal Health Innovation

Curated by ChEMBL
LigandPNGBDBM50435852(CHEMBL2393585)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of Mycobacterium tuberculosis TrxR after 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342519(CHEMBL1771809 | triethylammonium 5-(2-(2-(4-(3-(5-...)
Affinity DataKd:  42nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342519(CHEMBL1771809 | triethylammonium 5-(2-(2-(4-(3-(5-...)
Affinity DataKd:  17nMAssay Description:Inhibition of BCR/ABL1 (unknown origin) expressed in mouse 32D cells assessed as BCR-ABL1-mediated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342519(CHEMBL1771809 | triethylammonium 5-(2-(2-(4-(3-(5-...)
Affinity DataKd:  50nMAssay Description:Binding affinity to human A2A adenosine receptor expressed in HEK293 cells after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342519(CHEMBL1771809 | triethylammonium 5-(2-(2-(4-(3-(5-...)
Affinity DataKd:  31nMAssay Description:Inhibition of BCR/ABL1 (unknown origin) expressed in mouse Ba/F3 cells assessed as BCR-ABL1-mediated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50342519(CHEMBL1771809 | triethylammonium 5-(2-(2-(4-(3-(5-...)
Affinity DataKd:  29nMAssay Description:Binding affinity to C-terminal 10xHis and 1D4-tagged C-terminal-truncated human A2A adenosine receptor (1 to 316 residues) expressed in Pichia pastor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558569(CHEMBL4795911)
Affinity DataEC50:  3.20nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558570(CHEMBL4789805)
Affinity DataEC50:  0.780nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558571(CHEMBL4744050)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558572(CHEMBL4784379)
Affinity DataEC50:  1.40nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558573(CHEMBL4758549)
Affinity DataEC50:  3.10nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558574(CHEMBL4795356)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kissei Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50558575(CHEMBL4796518)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human ERbeta receptor expressed in HEK293T cells transfected with pGL4.27-(ERE)3-Luc assessed as transcriptional activation measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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