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Found 114 with Last Name = 'hanson' and Initial = 'gj'
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50:  1nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50:  2nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50008057(BMS-722782 | CHEBI:64153 | TANESPIMYCIN)
Affinity DataIC50:  3nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50:  4nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50008057(BMS-722782 | CHEBI:64153 | TANESPIMYCIN)
Affinity DataIC50:  4nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50:  5nMAssay Description:Inhibition of HSP90 in human A375 cells assessed as induction of HSP70 synthesis after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480378(CHEMBL563608)
Affinity DataIC50:  7nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50008057(BMS-722782 | CHEBI:64153 | TANESPIMYCIN)
Affinity DataIC50:  8nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(CHEMBL553939 | SNX-5422)
Affinity DataIC50:  11nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50:  11nMAssay Description:Inhibition of HSP90-mediated pS6 phosphorylation in human A375 cells after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19440(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(CHEMBL553939 | SNX-5422)
Affinity DataIC50:  13nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480378(CHEMBL563608)
Affinity DataIC50:  14nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as Hsp70 induction after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480378(CHEMBL563608)
Affinity DataIC50:  16nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19439(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287637((S)-3-{(S)-2-[(S)-2-((S)-2-Acetylamino-3-naphthale...)
Affinity DataIC50:  31nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50008057(BMS-722782 | CHEBI:64153 | TANESPIMYCIN)
Affinity DataIC50:  32nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379853(CHEMBL2011854)
Affinity DataIC50:  36nMAssay Description:Inhibition of HSP90-mediated Erk phosphorylation in human AU565 cells after 24 hrs by TRITC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19435(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  40nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50450704(CHEMBL560895 | SNX-2112)
Affinity DataIC50:  41nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as pERK degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480374(CHEMBL560955)
Affinity DataIC50:  46nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366440(CHEMBL1790415 | SC-67655)
Affinity DataIC50:  50nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19430(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480379(CHEMBL553939 | SNX-5422)
Affinity DataIC50:  61nMAssay Description:Inhibition of Hsp90 in human A375 cells assessed as pS6 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19438(4-{5-[(8aS)-octahydropyrrolo[1,2-a]piperazin-2-yl]...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287642((S)-3-({1-[(S)-6-Amino-2-(3-bicyclo[2.2.1]hept-2-y...)
Affinity DataIC50:  76nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTumor necrosis factor receptor superfamily member 10A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287632(CHEMBL1253325 | PKYVKQNTLKLAT (HA306-318 peptide))
Affinity DataIC50:  80nMAssay Description:Compound was tested for its ability to compete for binding to DR4 using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366444(CHEMBL1790402)
Affinity DataIC50:  100nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19437(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19431(4-[3-(4-chlorophenyl)-5-(3,5-dimethylpiperidin-1-y...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19432(4-[3-(4-chlorophenyl)-5-(4-methylpiperidin-1-yl)-1...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287650((S)-3-({1-[2-Cyclohexyl-2-((R)-3-cyclohexyl-butyry...)
Affinity DataIC50:  130nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287636((S)-3-({1-[(S)-6-Amino-2-((S)-3-cyclohexyl-butyryl...)
Affinity DataIC50:  162nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287628((S)-3-({1-[(S)-2-(3-Cyclohexyl-propionylamino)-3-m...)
Affinity DataIC50:  170nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366439(CHEMBL1793835)
Affinity DataIC50:  178nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366439(CHEMBL1793835)
Affinity DataIC50:  178nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287630((S)-3-({1-[(S)-6-Amino-2-(3-cycloheptyl-propionyla...)
Affinity DataIC50:  178nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287626((S)-2-((2S,3R)-2-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-...)
Affinity DataIC50:  180nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19434(2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19436(1-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19433(2-[3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  260nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287640(1-[(S)-2-((R)-3-Cyclohexyl-butyrylamino)-3-methyl-...)
Affinity DataIC50:  293nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379848(CHEMBL2011850)
Affinity DataIC50:  401nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human SKBR3 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHLA class II histocompatibility antigen, DR beta 3 chain(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287649((S)-3-({1-[2-((R)-3-Cyclohexyl-butyrylamino)-2-phe...)
Affinity DataIC50:  424nMAssay Description:Ability to compete for binding to Class II MHC using ELISA assay.More data for this Ligand-Target Pair
In DepthDetails Article
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50480372(CHEMBL562990)
Affinity DataIC50:  490nMAssay Description:Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screeningMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379854(CHEMBL2011855)
Affinity DataIC50:  498nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379841(CHEMBL2011843)
Affinity DataIC50:  568nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human SKBR3 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

LigandPNGBDBM19429(4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine | S...)
Affinity DataIC50:  600nMpH: 7.5 T: 2°CAssay Description:Kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 50 uM ATP/[gamma-33P] ATP. 33P incorpor...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379845(CHEMBL2011847)
Affinity DataIC50:  665nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human SKBR3 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Serenex

Curated by ChEMBL
LigandPNGBDBM50379840(CHEMBL2011853)
Affinity DataIC50:  705nMAssay Description:Inhibition of HSP90-mediated Her2 degradation in human AU565 cells after 24 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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