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Found 192 with Last Name = 'harper' and Initial = 'g'
TargetAurora kinase A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of AURAMore data for this Ligand-Target Pair
TargetAurora kinase C(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of AURCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataKi:  5nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  18nMAssay Description:Inhibition of AURBMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  30nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043224(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043221(3-Mercapto-6-methyl-4-(1-methylcarbamoyl-2-phenyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043228(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8344(6-aryl-pyrazolo[3,4-b]pyridine analogue 8 | CHEMBL...)
Affinity DataIC50:  8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043227(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450368(CHEMBL2115216)
Affinity DataIC50:  12nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043237(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450368(CHEMBL2115216)
Affinity DataIC50:  12nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043222(4-(2-Benzyloxy-1-methylcarbamoyl-propylcarbamoyl)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286132((S)-2-((S)-1-Mercapto-ethyl)-4-methyl-pentanoic ac...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043235(2-(1-Mercapto-ethyl)-4-methyl-pentanoic acid [2-(4...)
Affinity DataIC50:  17nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043242(3-Acetylsulfanyl-4-[2-(1H-indol-3-yl)-1-methylcarb...)
Affinity DataIC50:  19nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283786(CHEMBL328917 | {(R)-3-(6-Bromo-1,3-dioxo-1H,3H-ben...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043231(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  21nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043223(4-[2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbam...)
Affinity DataIC50:  22nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043238(2-Isobutyl-3-mercapto-pentanedioic acid 5-amide 1-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043230(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285719(CHEMBL315898 | N*4*-Hydroxy-2-isobutyl-N*1*-(2-oxo...)
Affinity DataIC50:  26nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043229(CHEMBL130164 | {3-Mercapto-4-[2-(4-methoxy-phenyl)...)
Affinity DataIC50:  27nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)
Affinity DataIC50:  27nMAssay Description:Inhibition of TGFBR1More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283785(CHEMBL98233 | {(R)-3-(1,3-Dioxo-1H,3H-benzo[de]iso...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286139((S)-2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid ...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043243(2-Isobutyl-3-mercapto-pentanedioic acid 5-carbamoy...)
Affinity DataIC50:  32nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50069571(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50:  33nMAssay Description:Potency of the compound at Endothelin A receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043232(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  34nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine--tRNA ligase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50126419(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Affinity DataIC50:  34nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285715((S)-3-Mercapto-6-methyl-4-(8-oxo-1,7diaza-cyclotri...)
Affinity DataIC50:  44nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043220(3-Acetylsulfanyl-4-[2-(4-methoxy-phenyl)-1-methylc...)
Affinity DataIC50:  44nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043734(((R)-1-{(S)-1-[(S)-2-(1H-Indol-3-yl)-1-methylcarba...)
Affinity DataIC50:  50nMAssay Description:Inhibition of degradation of radiolabeled rat skin type I collagen by semipurified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285716(3-Mercapto-6-methyl-4-(2-oxo-azacyclotridec-3-ylca...)
Affinity DataIC50:  51nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286135((S)-2-(2-Mercapto-benzyl)-4-methyl-pentanoic acid ...)
Affinity DataIC50:  55nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043224(3-Mercapto-4-[2-(4-methoxy-phenyl)-1-methylcarbamo...)
Affinity DataIC50:  68nMAssay Description:Inhibition of rat skin type I collagen degradation by purified human lung fibroblast collagenase without beta-mercaptoethanolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50069573(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...)
Affinity DataIC50:  97nMAssay Description:Potency of the compound at Endothelin A receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043225(2-Isobutyl-3-mercapto-5-(4-methyl-piperazin-1-yl)-...)
Affinity DataIC50:  120nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286133(2-(2-Mercapto-4-methoxy-benzyl)-4-methyl-pentanoic...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043234(2-Isobutyl-3-mercapto-pentanedioic acid 1-{[2-(4-m...)
Affinity DataIC50:  145nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043733(((R)-1-{(S)-1-[(S)-2-(1H-Benzoimidazol-2-yl)-1-met...)
Affinity DataIC50:  150nMAssay Description:Inhibition of degradation of radiolabeled rat skin type I collagen by semipurified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50069565(3-Benzo[1,3]dioxol-5-yl-1-benzo[1,3]dioxol-5-ylmet...)
Affinity DataIC50:  150nMAssay Description:Potency of the compound at Endothelin A receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50283783(CHEMBL330729 | {(S)-3-(1,3-Dioxo-1H,3H-benzo[de]is...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50286128((S)-2-(2-Mercapto-3-methoxy-benzyl)-4-methyl-penta...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity was tested against human collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50285717(CHEMBL87377 | {1-[3-Methyl-1-(2-oxo-azacyclotridec...)
Affinity DataIC50:  183nMAssay Description:Inhibition of semi-purified human lung fibroblast collagenaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043233(4-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-3-mercapto...)
Affinity DataIC50:  190nMAssay Description:Inhibition of radiolabeled rat skin type I collagen degradation by purified human lung fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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