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Found 48 with Last Name = 'hazlehurst' and Initial = 'la'
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.121nMAssay Description:Inhibition of human PIM3 using RSRHSSYPAGT as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of CDK5/P25 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CDK1/Cyclin A (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK3/Cyclin E (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of CDK1/Cyclin A (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human DAPK1 using KKLNRTLSFAEPG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
TargetCyclin-K(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-K/Cyclin-dependent kinase 9(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50:  38nMAssay Description:Inhibition of CDK3/Cyclin E (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  910nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute

Curated by ChEMBL
LigandPNGBDBM50433369(CHEMBL2377825)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)-mediated phosphorylation of peptide substrate incubated for 15 mins prior to substrate addition measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetERO1-like protein alpha(Mus musculus)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50265447(CHEMBL4060344)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of GST-SMT3-tagged mouse ERO1alpha (23 to 464 residues) expressed in Escherichia coli rosetta (DE3) using reduced thioredoxin as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50265392(CHEMBL4088576)
Affinity DataIC50:  4.08E+3nMAssay Description:Inhibition of human PIM3 using RSRHSSYPAGT as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505175(CHEMBL4303182)
Affinity DataIC50:  4.16E+3nMAssay Description:Inhibition of recombinant human LSD1 using ARTK(diMethyl)QTARKSTGGKAPRKQLAPRKQLA as substrate measured after 30 mins by ADHP/horseradish peroxidase c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505175(CHEMBL4303182)
Affinity DataIC50:  7.91E+3nMAssay Description:Inhibition of MAOA (unknown origin) using kynuramine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614909(CHEMBL5275946)
Affinity DataIC50:  9.12E+3nMAssay Description:Displacement of [3H]rosiglitazone from mitoNEET (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetERO1-like protein alpha(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505176(CHEMBL4589116)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibition of recombinant human Ero1Lalpha C104A/C131A/C166A triple mutant (22 to 468 residues) expressed in Escherichia coli BL21(DE3)-RIL measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614910(CHEMBL5275915)
Affinity DataIC50:  1.24E+4nMAssay Description:Displacement of [3H]rosiglitazone from mitoNEET (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetERO1-like protein alpha(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505175(CHEMBL4303182)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of recombinant human Ero1Lalpha C104A/C131A/C166A triple mutant (22 to 468 residues) expressed in Escherichia coli BL21(DE3)-RIL measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614909(CHEMBL5275946)
Affinity DataIC50:  1.83E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetERO1-like protein alpha(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505175(CHEMBL4303182)
Affinity DataIC50:  2.21E+4nMAssay Description:Inhibition of recombinant human Ero1Lalpha C104A/C131A/C166A triple mutant (22 to 468 residues) expressed in Escherichia coli BL21(DE3)-RIL using hum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Bos taurus)
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50265392(CHEMBL4088576)
Affinity DataIC50:  2.33E+4nMAssay Description:Binding affinity to bovine serum albumin by tryptophan quenching based HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614910(CHEMBL5275915)
Affinity DataIC50:  2.58E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50505175(CHEMBL4303182)
Affinity DataIC50:  3.06E+4nMAssay Description:Inhibition of MAOB (unknown origin) using kynuramine as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614899(CHEMBL5284856)
Affinity DataIC50:  3.06E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614900(CHEMBL5282131)
Affinity DataIC50:  4.00E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614898(CHEMBL5285507)
Affinity DataIC50:  4.50E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM13075(2,4-dichloro-5-sulfamoylbenzoic acid | 2000-01951 ...)
Affinity DataIC50:  4.52E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614901(CHEMBL5276945)
Affinity DataIC50:  5.43E+4nMAssay Description:Displacement of [3H]rosiglitazone from mitoNEET (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614901(CHEMBL5276945)
Affinity DataIC50:  7.42E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614908(CHEMBL5276914)
Affinity DataIC50:  7.86E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614908(CHEMBL5276914)
Affinity DataIC50:  8.14E+4nMAssay Description:Displacement of [3H]rosiglitazone from mitoNEET (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataIC50:  1.02E+5nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614897(CHEMBL5281122)
Affinity DataIC50:  1.90E+5nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM25902(4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...)
Affinity DataKd:  5.30E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by SPR methodMore data for this Ligand-Target Pair
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614907(CHEMBL5283699)
Affinity DataEC50:  4.53E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614906(CHEMBL5281138)
Affinity DataEC50:  2.36E+5nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614905(CHEMBL5271611)
Affinity DataEC50:  5.82E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614904(CHEMBL5275408)
Affinity DataEC50:  1.07E+5nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614902(CHEMBL5283164)
Affinity DataEC50:  1.01E+5nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614896(CHEMBL5280319)
Affinity DataEC50:  7.33E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614895(CHEMBL5276106)
Affinity DataEC50:  4.37E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataKd:  1.92E+3nMAssay Description:Binding affinity to mitoNEET (unknown origin) by ITC methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50265392(CHEMBL4088576)
Affinity DataEC50:  3.95E+4nMAssay Description:Activation of human DAPK1 using KKLNRTLSFAEPG as substrate in presence of [gamma-33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM50614903(CHEMBL5270332)
Affinity DataEC50:  3.49E+4nMAssay Description:Binding affinity to mitoNEET (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed