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Found 163 with Last Name = 'hudock' and Initial = 'mp'
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataKi:  10nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25279(BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25289(bisphosphonate, 38 | {1-hydroxy-2-[3-(3-phenylphen...)
Affinity DataKi:  60nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25279(BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-...)
Affinity DataKi:  60nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataKi:  80nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25288(BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...)
Affinity DataKi:  110nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25289(bisphosphonate, 38 | {1-hydroxy-2-[3-(3-phenylphen...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25288(BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...)
Affinity DataKi:  110nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataKi:  130nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataKi:  230nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Affinity DataKi:  260nMAssay Description:Binding affinity to Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Affinity DataKi:  2.70E+3nMAssay Description:Binding affinity to human GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25297(1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25279(BPH-608 | bisphosphonate, 31 | {1-hydroxy-2-[3-(3-...)
Affinity DataIC50:  70nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25256(bisphosphonate, 9 | hydrogen [2-(dodecyldimethylph...)
Affinity DataIC50:  100nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50098390((3-methylpyridin-2-ylamino)methylenediphosphonic a...)
Affinity DataIC50:  112nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25289(bisphosphonate, 38 | {1-hydroxy-2-[3-(3-phenylphen...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)
Affinity DataIC50:  170nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25284((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50180147((cycloheptylamino-hydroxy-phosphono-methyl)-phosph...)
Affinity DataIC50:  228nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50225571(2-(methyl, decylsulfonium-1-yl)ethylidene-1,1-bisp...)
Affinity DataIC50:  251nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25272(CHEMBL238046 | bisphosphonate, 25 | hydrogen {2-[d...)
Affinity DataIC50:  260nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25258(3-(decyloxy)-5-(2-hydrogen phosphonato-2-phosphono...)
Affinity DataIC50:  280nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25288(BPH-629 | [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...)
Affinity DataIC50:  280nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50:  340nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25260(bisphosphonate, 16 | {2-[dodecyl(methyl)amino]-1-p...)
Affinity DataIC50:  350nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25287(CHEMBL235690 | bisphosphonate, 37 | hydrogen {2-[m...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25261(3-decyl-1-(2-hydrogen phosphonato-2-phosphonoethyl...)
Affinity DataIC50:  400nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyprenyl synthetase family protein(Plasmodium falciparum (isolate 3D7))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50138041(1-hydroxy-3-(methyl(2-phenoxyethyl)amino)propane-1...)
Affinity DataIC50:  420nMAssay Description:Inhibitory activity against FPPS in Leishmania majorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25262(3-bromo-5-(decyloxy)-1-(2-hydrogen phosphonato-2-p...)
Affinity DataIC50:  510nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM25303(CHEMBL235059 | bisphosphonate, 50 | hydrogen {2-[m...)
Affinity DataIC50:  530nMAssay Description:Inhibition of human FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25263(bisphosphonate, 19 | {2-[3-(decyloxy)phenyl]-1-hyd...)
Affinity DataIC50:  590nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase BTS1(Saccharomyces cerevisiae (Yeast))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM12578(2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...)
Affinity DataIC50:  660nMAssay Description:Inhibition of Saccharomyces cerevisiae GGPPSMore data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25264(1-(2-hydrogen phosphonato-2-phosphonoethyl)-4-octy...)
Affinity DataIC50:  660nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl diphosphate synthase(Escherichia coli K-12)
University Of Illinois At Urbana - Champaign

Curated by ChEMBL
LigandPNGBDBM50370779(CHEMBL199858)
Affinity DataIC50:  700nMAssay Description:Inhibition of Escherichia coli FPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25265((1-hydroxy-1-phosphonononyl)phosphonic acid | CHEM...)
Affinity DataIC50:  710nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)
Affinity DataIC50:  720nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25266(BPH-628 | bisphosphonate, 21 | {1-hydroxy-2-[3-(4-...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human GGPPSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25267(3-(decyloxy)-5-(3,5-difluorophenyl)-1-(2-hydrogen ...)
Affinity DataIC50:  760nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50180152((9-ethyl-9H-3-carbazolyl)-aminomethylene-1,1-bisph...)
Affinity DataIC50:  810nMAssay Description:Inhibitory activity against Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25269((1-hydroxy-1-phosphonodecyl)phosphonic acid | CHEM...)
Affinity DataIC50:  890nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25268(bisphosphonate, 22 | hydrogen {2-[dimethyl(octyl)p...)
Affinity DataIC50:  890nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphotransferase(Trypanosoma cruzi)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL
LigandPNGBDBM50173799((3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate...)
Affinity DataIC50:  950nMAssay Description:Inhibitory activity against Trypanosoma cruzi hexokinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
Institute Of Biological Chemistry

Curated by ChEMBL
LigandPNGBDBM25270([(6E,11E)-2,6,12,16-tetramethyl-9-phosphonoheptade...)
Affinity DataIC50:  980nMpH: 7.0 T: 2°CAssay Description:The inhibitory activity of each test compound was evaluated by monitoring the formation of [14C]GGPP from FPP, using [14C]IPP as the substrate. To co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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