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Found 2729 with Last Name = 'ino' and Initial = 'y'
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of human recombinant matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50143729((2R,3R,4R,5R)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.0970nMAssay Description:Inhibition of human recombinant matrix metalloprotease 9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109621(CHEMBL425316 | [4-(4-Amino-phenoxy)-phenyl]-(3-hyd...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109626(Biphenyl-4-yl-(3-hydroxycarbamoyl-3,4-dihydro-1H-i...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50143729((2R,3R,4R,5R)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human tumor necrosis factor-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50141575((2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109621(CHEMBL425316 | [4-(4-Amino-phenoxy)-phenyl]-(3-hyd...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of human recombinant matrix metalloprotease 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131385((2R,3R,4R,5S)-3,4,5-Trihydroxy-1-(4-phenoxy-benzen...)
Affinity DataKi:  0.510nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141577((2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of human tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.530nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141577((2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-...)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141576((3aR,6R,7R,7aS)-5-(4-But-2-ynyloxy-benzenesulfonyl...)
Affinity DataKi:  0.570nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50343939((S)-2-(6-hydroxy-6-methylheptan-2-ylamino)-4-methy...)
Affinity DataKi:  0.590nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109625((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141574((3aR,6R,7R,7aR)-5-(4-But-2-ynyloxy-benzenesulfonyl...)
Affinity DataKi:  0.840nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095656(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(3-met...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131382((2R,3R,4R,5S)-1-(4-Cyclohexyloxy-benzenesulfonyl)-...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109629((4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataKi:  0.970nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129387((R)-1-(4-Amino-piperidin-1-yl)-2-cyclopentyl-2-hyd...)
Affinity DataKi:  0.980nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129390((R)-1-[4-(2-Amino-ethyl)-4-ethyl-piperidin-1-yl]-2...)
Affinity DataKi:  1nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Recombinant human matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129399((R)-1-[4-(2-Amino-ethyl)-piperidin-1-yl]-2-cyclope...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataKi:  1.13nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129392((R)-1-[4-(2-Amino-ethylidene)-piperidin-1-yl]-2-((...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095679(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(3-hyd...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50343938(CHEMBL1778662 | rac-2-(6-hydroxy-6-methylheptan-2-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of aurora AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129392((R)-1-[4-(2-Amino-ethylidene)-piperidin-1-yl]-2-((...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymase(Homo sapiens (Human))
Green Cross Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50068901(3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-pheny...)
Affinity DataKi:  1.30nMAssay Description:Compound was evaluated for inhibitory activity against human heart chymase (HHC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095662(2-Cyclopentyl-2-hydroxy-N-[1-(3-methyl-benzyl)-pip...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129387((R)-1-(4-Amino-piperidin-1-yl)-2-cyclopentyl-2-hyd...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095657((R)-N-[1-(6-Amino-pyridin-2-ylmethyl)-piperidin-4-...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]-NMS binding to human muscarinic acetylcholine receptor M1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095657((R)-N-[1-(6-Amino-pyridin-2-ylmethyl)-piperidin-4-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129397((R)-1-[4-(2-Amino-ethyl)-4-methyl-piperidin-1-yl]-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50131381((2R,3R,4R,5S)-1-(4-Benzyloxy-benzenesulfonyl)-3,4,...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131386((2R,3S,4R,5S)-3,4,5-Trihydroxy-1-(4-methoxy-benzen...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129410((R)-1-(4-Aminomethyl-piperidin-1-yl)-2-cyclopentyl...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity against human muscarinic acetylcholine receptor M3 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50143732((2R,3R,4R,5R)-1-(4-Benzyloxy-benzenesulfonyl)-3,4,...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Hokkaido Collaboration Center N-21

Curated by ChEMBL
LigandPNGBDBM50131382((2R,3R,4R,5S)-1-(4-Cyclohexyloxy-benzenesulfonyl)-...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50129410((R)-1-(4-Aminomethyl-piperidin-1-yl)-2-cyclopentyl...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity against human Muscarinic acetylcholine receptor M1 in transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  1.81nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141578((3aR,4R,7R,7aR)-5-(4-But-2-ynyloxy-benzenesulfonyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Hokkaido Collaboration Center

Curated by ChEMBL
LigandPNGBDBM50141575((2R,3R,4R,5R)-1-(4-But-2-ynyloxy-benzenesulfonyl)-...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant human TNF-alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50095656(2-(3,3-Difluoro-cyclopentyl)-2-hydroxy-N-[1-(3-met...)
Affinity DataKi:  2nMAssay Description:Ability to inhibit binding of [3H]-NMS was determined by receptor binding assay using membranes from chinese hamster ovary (CHO) cells expressing clo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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