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Found 80 with Last Name = 'inskeep' and Initial = 'pb'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  12nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041289((S)-2-Hexylsulfanyl-decanoic acid (6-methyl-2,4-bi...)
Affinity DataIC50:  22nMAssay Description:In vitro potency was determined using Acyl coenzyme A:cholesterol acyltransferase in liver microsomes from ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  46nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  49nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006496((7-Bromo-6-chloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  50nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006490((+)-(7-Chloro-6-fluoro-4-hydroxy-2-methyl-chroman-...)
Affinity DataIC50:  60nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006500((7-Benzyloxy-6-chloro-4-hydroxy-2-methyl-chroman-4...)
Affinity DataIC50:  60nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006530((7-Fluoro-4-hydroxy-2-methyl-6-nitro-chroman-4-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006493(4-Carboxymethyl-4-hydroxy-2-methyl-chroman-7-carbo...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006496((7-Bromo-6-chloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006532((4-Hydroxy-2-methyl-6-nitro-chroman-4-yl)-acetic a...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006507((7-Bromo-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006533((4-Hydroxy-2,7-dimethyl-6-nitro-chroman-4-yl)-acet...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006529((6-Chloro-7-ethyl-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006504((7-Chloro-4-hydroxy-2-methyl-6-nitro-chroman-4-yl)...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006507((7-Bromo-6-fluoro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  120nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006509((6-Cyano-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50041290((S)-2-Hexylsulfanyl-decanoic acid (6-methylsulfany...)
Affinity DataIC50:  135nMAssay Description:In vitro potency was determined using Acyl coenzyme A:cholesterol acyltransferase in liver microsomes from ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006502((+)-(6,7-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  140nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006502((+)-(6,7-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  156nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50453642(CHEMBL2093028)
Affinity DataIC50:  160nMAssay Description:In vitro potency was determined using Acyl coenzyme A:cholesterol acyltransferase in liver microsomes from ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006502((+)-(6,7-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  180nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006502((+)-(6,7-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)...)
Affinity DataIC50:  180nMAssay Description:ARI(aldose reductase inhibitor) enantiospecificity against human placental aldose reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006513((6-Chloro-4-hydroxy-7-methoxy-2-methyl-chroman-4-y...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006506((6-Fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic ...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006524((6-Chloro-4-hydroxy-2,7-dimethyl-chroman-4-yl)-ace...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006498((6,7-Difluoro-4-hydroxy-2-methyl-chroman-4-yl)-ace...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006506((6-Fluoro-4-hydroxy-2-methyl-chroman-4-yl)-acetic ...)
Affinity DataIC50:  310nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006498((6,7-Difluoro-4-hydroxy-2-methyl-chroman-4-yl)-ace...)
Affinity DataIC50:  350nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006508((2-tert-Butyl-6-fluoro-4-hydroxy-chroman-4-yl)-ace...)
Affinity DataIC50:  360nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006519((6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006535((6-Chloro-4-hydroxy-2-methyl-3,4-dihydro-2H-benzo[...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006534((4-Hydroxy-2,2-dimethyl-6-nitro-chroman-4-yl)-acet...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006519((6-Chloro-7-fluoro-4-hydroxy-2-methyl-chroman-4-yl...)
Affinity DataIC50:  410nMAssay Description:Compound was tested in vitro for its inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006503((6-Fluoro-4-hydroxy-2-isopropyl-chroman-4-yl)-acet...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006523((6-Fluoro-4-hydroxy-chroman-4-yl)-acetic acid | CH...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006488((2-Ethyl-6-fluoro-4-hydroxy-chroman-4-yl)-acetic a...)
Affinity DataIC50:  620nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006536((6-Acetyl-4-hydroxy-2-methyl-chroman-4-yl)-acetic ...)
Affinity DataIC50:  650nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50453641(CHEMBL2093029)
Affinity DataIC50:  750nMAssay Description:In vitro potency was determined using Acyl coenzyme A:cholesterol acyltransferase in liver microsomes from ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006510((7,8-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)-ace...)
Affinity DataIC50:  780nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006512((6-Chloro-4-hydroxy-2-methyl-chroman-4-yl)-acetic ...)
Affinity DataIC50:  820nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006538((6-Fluoro-4-hydroxy-2,3-dimethyl-chroman-4-yl)-ace...)
Affinity DataIC50:  910nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006491((6-Fluoro-4-hydroxy-2-propyl-chroman-4-yl)-acetic ...)
Affinity DataIC50:  970nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006521((6,8-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)-ace...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006499((6-Fluoro-4-hydroxy-2-phenethyl-chroman-4-yl)-acet...)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006511((6-Chloro-4-hydroxy-2,8-dimethyl-chroman-4-yl)-ace...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50368324(CHEMBL1744091)
Affinity DataIC50:  1.39E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006492((4-Hydroxy-2,5-dimethyl-5-nitro-3,4,5,6-tetrahydro...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006520((5,6-Dichloro-4-hydroxy-2-methyl-chroman-4-yl)-ace...)
Affinity DataIC50:  1.63E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50006531((6-Bromo-4-hydroxy-2-methyl-chroman-4-yl)-acetic a...)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibitory activity against human placental aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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