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Found 164 with Last Name = 'irvin' and Initial = 'jd'
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50240609(2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataKi:  0.640nMAssay Description:Inhibitory activity against Angiotensin II receptor, type 1 in rat adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50241491(2-{4-Butyl-2-methyl-6-oxo-5-[2'-(1H-tetrazol-5-yl)...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity was evaluated towards Angiotensin II receptor, type 1 in rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171117(2-(4-(N-(3-bromo-4-(difluoro(phosphono)methyl)benz...)
Affinity DataKi:  13nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171106((4-{[(Benzyl-methyl-carbamoyl)-methyl]-[3-bromo-4-...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049210(CHEMBL348126 | N-{4-[2-Butyl-6-(3-methyl-1-pentyl-...)
Affinity DataKi:  20nMAssay Description:Ki value was evaluated against Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035429(4'-[2-Butyl-6-(3-cyclohexyl-ureido)-benzoimidazol-...)
Affinity DataKi:  29nMAssay Description:Ki value was evaluated against Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171096(CHEMBL371929 | {4-[[3-Bromo-4-(difluoro-phosphono-...)
Affinity DataKi:  53nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171100(CHEMBL198882 | {4-[[4-(Difluoro-phosphono-methyl)-...)
Affinity DataKi:  56nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171099((4-((N-(4-(1,2,3-thiadiazol-4-yl)benzyl)phenylsulf...)
Affinity DataKi:  98nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035429(4'-[2-Butyl-6-(3-cyclohexyl-ureido)-benzoimidazol-...)
Affinity DataKi:  480nMAssay Description:Ki value was evaluated against Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171118((4-{[(Benzyl-methyl-carbamoyl)-methyl]-[4-(difluor...)
Affinity DataKi:  590nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049210(CHEMBL348126 | N-{4-[2-Butyl-6-(3-methyl-1-pentyl-...)
Affinity DataKi:  730nMAssay Description:Ki value was evaluated against Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Affymax

Curated by ChEMBL
LigandPNGBDBM50171112(({4-[(Benzenesulfonyl-benzyl-amino)-methyl]-phenyl...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049199(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041969(3-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030711(CHEMBL338027 | L-163958 | Pentanoic acid {4-bromo-...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50030711(CHEMBL338027 | L-163958 | Pentanoic acid {4-bromo-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038189(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032353(CHEMBL100119 | N-{3-[5-Ethyl-3-(3-fluoro-2'-isopen...)
Affinity DataIC50:  0.280nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049203(CHEMBL160494 | L-163017 | N-[7-Methyl-2-propyl-3-(...)
Affinity DataIC50:  0.290nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50009718(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50031491(2-propyl-4-(methythio)-1-[[[2'-[(propylamino)carbo...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049214(2-Ethyl-5,7-dimethyl-3-[5'-propyl-2'-(1H-tetrazol-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049185(4'-[2-Butyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049204(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50:  0.390nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50035451(2-{4-[3-butyl-5-oxo-1-(2-trifluoromethylphenyl)-4,...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049204(2-ethyl-3-(3-fluoro-2'-(2-cyclopropylethyloxycarbo...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049182((S)-5-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity was evaluated against Angiotensin II receptor, type 2More data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049198(3-{2-Butyl-7-methyl-3-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049206(5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbaronylsulfa...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM82433(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049185(4'-[2-Butyl-6-(3-isopropyl-3-methyl-ureido)-4-oxo-...)
Affinity DataIC50:  0.940nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032362(3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032362(3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049189(3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50369183(CHEMBL290214 | L-163491)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049195(3-[(2'-(butylsulfonylcarbamate)-3'-propyl-1,1'-bip...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM82433(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049183(2,7-Diethyl-5-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity was evaluated against angiotensin II type 1 rabbit aortaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049179(4'-(4-Ethyl-5-formyl-2-propyl-imidazol-1-ylmethyl)...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049189(3-[4-(2-Ethyl-57-dimethyl-imidazo[45-b]pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Angiotensin II receptor, type 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049214(2-Ethyl-5,7-dimethyl-3-[5'-propyl-2'-(1H-tetrazol-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049181(2-Butyl-3-(2'-(butyloxycarbonylaminosulphonyl)-bip...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(RABBIT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50041963(CHEMBL24861 | {2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-2 angiotensin II receptor(RAT)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50032364(4'-(5-Acetyl-4-ethyl-2-propyl-imidazol-1-ylmethyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity at Angiotensin II type 2 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049187(5,7-Diethyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  3.80nMAssay Description:In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneMore data for this Ligand-Target Pair
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049193(9,28-dipropyl-13-sulfurdioxo-1,14,22,27-tetraazape...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50049178(2-Propyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-3...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047126(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  5nMAssay Description:In vitro antagonistic potency against Angiotensin II receptor, type 1 in guinea pig adrenal membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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