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Found 2123 with Last Name = 'iura' and Initial = 'y'
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513317(CHEMBL4465620)
Affinity DataKi:  68nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Kyoto Prefectural University Of Medicine

Curated by ChEMBL
LigandPNGBDBM50513318(CHEMBL4516553)
Affinity DataKi:  470nMAssay Description:Inhibition of human N-terminal His-tagged SIRT2 expressed in Escherichia coli using p53 (Gln-Pro-Lys-Lys(Ac)) (317 to 320 residues) as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50524981(CHEMBL4562879)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of N-terminal GST-tagged human TrkA kinase domain (436 to 790 residues) expressed in baculovirus expression system using biotin-poly-GT as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine palmitoyltransferase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50461646(CHEBI:582124 | Myriocin)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...More data for this Ligand-Target Pair
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50:  0.160nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390216(CHEMBL2070151)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390219(CHEMBL2070148)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysophosphatidic acid receptor 1(Homo sapiens (Human))
Ono Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50285779(CHEMBL4165205)
Affinity DataIC50:  0.190nMAssay Description:Antagonist activity at recombinant human LPA1 expressed in CHO cell membranes pretreated for 24 hrs prior to Fura-2-AM dye addition for 1 hr followed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390213(CHEMBL2069316)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394224(CHEMBL2159167)
Affinity DataIC50:  0.210nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM529296(US11198695, Example II-233)
Affinity DataIC50:  0.224nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394211(CHEMBL2159165)
Affinity DataIC50:  0.280nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM529321(US11198695, Example II-258)
Affinity DataIC50:  0.285nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394221(CHEMBL2159158)
Affinity DataIC50:  0.290nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390228(CHEMBL2070161)
Affinity DataIC50:  0.290nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390232(CHEMBL2070157)
Affinity DataIC50:  0.310nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine palmitoyltransferase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50461644(CHEMBL4228416)
Affinity DataIC50:  0.360nMAssay Description:Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM529320(US11198695, Example II-257)
Affinity DataIC50:  0.409nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394214(CHEMBL2159162)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]PYY from mouse NPY-Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394214(CHEMBL2159162)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390225(CHEMBL2070140)
Affinity DataIC50:  0.430nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM529322(US11198695, Example II-259)
Affinity DataIC50:  0.439nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390222(CHEMBL2070137)
Affinity DataIC50:  0.460nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine palmitoyltransferase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50461649(CHEMBL4225519)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390220(CHEMBL2070147)
Affinity DataIC50:  0.540nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50390234(CHEMBL2070155)
Affinity DataIC50:  0.550nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394218(CHEMBL2159156)
Affinity DataIC50:  0.600nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM403547(US10335401, No. I-57)
Affinity DataIC50:  0.620nMAssay Description:A full-length human MGAT2 gene to which a Flag-tag had been added at the N-terminal was inserted into pFastBac (from Invitrogen). A recombinant bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528979(US11198695, Example I-190 | US11198695, Example II...)
Affinity DataIC50:  0.706nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine palmitoyltransferase 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50461645(CHEMBL4228472)
Affinity DataIC50:  0.710nMAssay Description:Inhibition of human SPT2 transfected in Freestyle293 cells using L-serine and palmitoyl-CoA as substrate preincubated for 60 mins followed by substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM403538(US10335401, No. I-47)
Affinity DataIC50:  0.730nMAssay Description:A full-length human MGAT2 gene to which a Flag-tag had been added at the N-terminal was inserted into pFastBac (from Invitrogen). A recombinant bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394223(CHEMBL2159166)
Affinity DataIC50:  0.730nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394228(CHEMBL2159171)
Affinity DataIC50:  0.800nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Mus musculus (Mouse))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50394227(CHEMBL2159170)
Affinity DataIC50:  0.850nMAssay Description:Displacement of [125I]PYY from mouse NPY Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50394470(CHEMBL2160099)
Affinity DataIC50:  0.870nMAssay Description:Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 3(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50297172(CHEMBL560275 | N-{(3R)-1-[(6-Fluoro-2-naphthyl)met...)
Affinity DataIC50:  0.980nMAssay Description:Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM529343(US11198695, Example II-280)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528865(US11198695, Example I-77)
Affinity DataIC50:  1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529330(US11198695, Example II-267)
Affinity DataIC50:  1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529324(US11198695, Example II-261)
Affinity DataIC50:  1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529367(US11198695, Example II-305)
Affinity DataIC50:  1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529362(US11198695, Example II-300)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529360(US11198695, Example II-298)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529359(US11198695, Example II-297)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529358(US11198695, Example II-296)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529357(US11198695, Example II-295)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529356(US11198695, Example II-294)
Affinity DataIC50: <1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM529340(US11198695, Example II-277)
Affinity DataIC50:  1nMAssay Description:Solutions of the compounds of the present invention in DMSO were each aliquoted into 0.2-μL portions in a 384-well polystyrene microplate produc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM403534(US10335401, No. I-43)
Affinity DataIC50: <1nMAssay Description:A full-length human MGAT2 gene to which a Flag-tag had been added at the N-terminal was inserted into pFastBac (from Invitrogen). A recombinant bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM403562(US10335401, No. I-72)
Affinity DataIC50:  1nMAssay Description:A full-length human MGAT2 gene to which a Flag-tag had been added at the N-terminal was inserted into pFastBac (from Invitrogen). A recombinant bacul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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