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Found 284 with Last Name = 'ivashchenko' and Initial = 'aa'
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103506(CHEMBL2172186 | US8552017, 1.1(3).HCl)
Affinity DataKi:  0.389nM IC50:  0.837nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50314762(5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...)
Affinity DataKi:  0.440nM ΔG°:  -54.3kJ/mole IC50:  0.948nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50314759(2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...)
Affinity DataKi:  0.458nM ΔG°:  -54.2kJ/mole IC50:  0.986nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50314760(2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...)
Affinity DataKi:  0.549nM ΔG°:  -53.7kJ/mole IC50:  1.18nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103505(CHEMBL2172193 | US8552017, 2(4).HCl)
Affinity DataKi:  0.662nM IC50:  1.43nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50314763(9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...)
Affinity DataKi:  0.680nM ΔG°:  -53.2kJ/mole IC50:  1.46nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103507(CHEMBL2172187 | US8552017, 1.1(4).HCl)
Affinity DataKi:  0.685nM IC50:  1.48nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50340726(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Affinity DataKi:  2.14nM IC50:  4.61nMAssay Description:Radioligand binding assay using 5-HT6 receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103943(US8569318, 1.1(1))
Affinity DataKi:  2.14nM IC50:  46.1nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103504(CHEMBL2172192 | US8552017, 2(7).HCl)
Affinity DataKi:  3.26nM IC50:  7.02nMAssay Description:The screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out b the method of radio...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103944(US8569318, 1.2(2))
Affinity DataKi:  7.70nM IC50:  16.6nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50314761(2-Methylsulfanyl-3-phenylsulfonyl-5,6,7,8-tetrahyd...)
Affinity DataKi:  7.97nM ΔG°:  -47.0kJ/mole IC50:  17.2nMpH: 7.4 T: 2°CAssay Description:Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103945(US8569318, 1.2(6))
Affinity DataKi:  11.1nM IC50:  23.9nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50396228(CHEMBL2172183 | US8569318, 1.2(3))
Affinity DataKi:  35.7nM IC50:  76.9nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50396233(CHEMBL2172182 | US8569318, 1.1(3))
Affinity DataKi:  60nM IC50:  13nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  68.4nM IC50:  147nMAssay Description:Radioligand binding assay using 5-HT6 receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50340728(2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)
Affinity DataKi:  222nM IC50:  477nMAssay Description:Radioligand binding assay using 5-HT6 receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM50340729(5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...)
Affinity DataKi:  237nM IC50:  510nMAssay Description:Radioligand binding assay using 5-HT6 receptors.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM103946(CHEMBL2172189 | US8569318, 2.2(2))
Affinity DataKi:  372nM IC50:  801nMAssay Description:Activity test of serotonin 5-HT6 receptor antagonists of the general formulas 1, 2 in the setting of competitive binding to serotonin 5-HT6 receptors...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547638(CHEMBL4782728)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547646(CHEMBL4780371)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547634(CHEMBL4747100)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547628(CHEMBL4753603)
Affinity DataIC50:  0.00100nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547650(CHEMBL4797491)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547649(CHEMBL4793304)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547637(CHEMBL4745761)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547627(CHEMBL4755593)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547640(CHEMBL4746579)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547639(CHEMBL4744183)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547629(CHEMBL4763617)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547643(CHEMBL4764688)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547642(CHEMBL4780002)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547631(CHEMBL4798211)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547636(CHEMBL4744064)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547635(CHEMBL4798433)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547629(CHEMBL4763617)
Affinity DataIC50:  0.00300nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547645(CHEMBL4763486)
Affinity DataIC50:  0.00300nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547628(CHEMBL4753603)
Affinity DataIC50:  0.00300nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547641(CHEMBL4749253)
Affinity DataIC50:  0.00400nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM244106(US9428491, 1.1 | US9428491, 1.1: 2HCl | US9428491,...)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547646(CHEMBL4780371)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547638(CHEMBL4782728)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547643(CHEMBL4764688)
Affinity DataIC50:  0.00500nMAssay Description:Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547632(CHEMBL4787353)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547628(CHEMBL4753603)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547635(CHEMBL4798433)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547643(CHEMBL4764688)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547637(CHEMBL4745761)
Affinity DataIC50:  0.00700nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNonstructural protein 5A(Hepatitis C virus)
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50547630(CHEMBL4758660)
Affinity DataIC50:  0.00700nMAssay Description:Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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