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Found 156 with Last Name = 'jenkins-west' and Initial = 't'
LigandPNGBDBM50106179(CHEMBL125327 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Affinity DataIC50:  2nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106169(CHEMBL338973 | Enantiomer-4-(3-Butyl-[1,2,4]oxadia...)
Affinity DataIC50:  9nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301472(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106167(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Affinity DataIC50:  18nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106167(CHEMBL125000 | Enantiomer-4-(3-Cyclopropylmethyl-[...)
Affinity DataIC50:  18nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106178(4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-...)
Affinity DataIC50:  23nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106168(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  27nMAssay Description:Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106168(CHEMBL124448 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  27nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301473(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-methyl-1H-ben...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50061218((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...)
Affinity DataIC50:  31nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50099581(CHEMBL288131 | N-((2R,3R)-3-(4-ethylphenylsulfonam...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106176(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  40nMAssay Description:Bindind affinity values obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106176(CHEMBL340681 | Enantiomer-N-(2,2-Dimethyl-cyclopen...)
Affinity DataIC50:  40nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301471(7-(3,4-dichlorophenyl)-6-(5-fluoro-1-propyl-1H-ben...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306906(((R)-7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301469(6-(5-chloro-1-ethyl-1H-benzo[d]imidazol-2-yl)-7-(3...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211550((3S,4R)-4-(N-butyl-4-ethylphenylsulfonamido)-3-hyd...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301456(7-(3,4-dichlorophenyl)-6-(4-fluoro-1-methyl-1H-ben...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301459(6-(5-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)-7-(...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254617(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306891((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306891((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254617(7-(3,4-dichlorophenyl)-5-methyl-N,N-dipropyl-4,7-d...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254809((R)-(7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropy...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301457(6-(7-chloro-1-methyl-1H-benzo[d]imidazol-2-yl)-7-(...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301452(7-(3,4-dichlorophenyl)-5-methyl-6-(1-methyl-1H-ben...)
Affinity DataIC50:  75nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211518((3S,4R)-N-ethyl-4-(4-ethylphenylsulfonamido)-3-hyd...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211521(CHEMBL388762 | N-((3S,4R)-6-(5-amino-3-phenyl-1H-p...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254736((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  85nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211547(CHEMBL228808 | N-((3R,4S)-6-((R)-2-((2,6-dimethylp...)
Affinity DataIC50:  89nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306905((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254698(5-(1-cyclohexylvinyl)-4-(3,4-dimethylphenyl)-6-met...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301470(6-(5-chloro-1-isopropyl-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254656(7-(3,4-dichlorophenyl)-5-methyl-N-phenethyl-4,7-di...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306904((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211514(CHEMBL228809 | N-((S)-6-((S)-2-((2,6-dimethylpheny...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301460(7-(3,4-dichlorophenyl)-6-(1,7-dimethyl-1H-benzo[d]...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211537((3S,4R)-4-(4-ethyl-N-neopentylphenylsulfonamido)-3...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254929((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211535(CHEMBL387993 | N-((3S,4R)-6-((S)-2-((2,6-dimethylp...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211525((3S,4R)-4-(4-ethyl-N-(pyridin-2-ylmethyl)phenylsul...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50106182(CHEMBL123085 | N-(3,3-Dimethyl-butyl)-4-(3-phenyl-...)
Affinity DataIC50:  130nMAssay Description:Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211523((3S,4R)-4-(4-ethyl-N-(pyridin-3-ylmethyl)phenylsul...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211542(CHEMBL230251 | N-((3S,4R)-6-((R)-2-((2,6-dimethylp...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50254966((7-(3,5-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cells by EP voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301454(7-(3,4-dichlorophenyl)-6-(7-fluoro-1-methyl-1H-ben...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301453(7-(3,4-dichlorophenyl)-5-methyl-6-(7-methyl-1H-ben...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306893((2S)-methyl 1-(7-(3,4-dichlorophenyl)-5-methyl-4,7...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50211520((3S,4R)-3-hydroxy-2,2-dimethyl-N-phenethyl-4-(2-(t...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50306890((7-(3,4-dichlorophenyl)-5-methyl-4,7-dihydropyrazo...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human Kv1.5 channel expressed in mouse L929 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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