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Found 1583 with Last Name = 'jeong' and Initial = 'jw'
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458125(CHEMBL4217352)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458125(CHEMBL4217352)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of ENPP2 in human A2058 cells using LPC as substrate preincubated for 15 mins followed by substrate addition measured after 3 hrs by LC-MS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458132(CHEMBL4205127)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458135(CHEMBL4214731)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458131(CHEMBL4212398)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458127(CHEMBL4211269)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458126(CHEMBL4203076)
Affinity DataIC50:  2nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458125(CHEMBL4217352)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human ENPP2 using bis-pNPP as substrate measured every 10 secs for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458135(CHEMBL4214731)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human ENPP2 using bis-pNPP as substrate measured every 10 secs for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458126(CHEMBL4203076)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human ENPP2 using bis-pNPP as substrate measured every 10 secs for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458136(CHEMBL4216236)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458133(CHEMBL4216825)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458124(CHEMBL4208368)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380413(CHEMBL2018573)
Affinity DataIC50:  4.80nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393357(CHEMBL2152148)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458132(CHEMBL4205127)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human ENPP2 using bis-pNPP as substrate measured every 10 secs for 10 mins by spectrophotometric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380417(CHEMBL2018485)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380418(CHEMBL2018571)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393365(CHEMBL2152257)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310205(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380410(CHEMBL2018484)
Affinity DataIC50:  6.80nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458128(CHEMBL4206899)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458129(CHEMBL4209155)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458125(CHEMBL4217352)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of ENPP2 in human SKHEP1 cells using LPC as substrate preincubated for 15 mins followed by substrate addition measured after 3 hrs by LC-M...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393359(CHEMBL2152150)
Affinity DataIC50:  8nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458130(CHEMBL4204027)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458134(CHEMBL4203499)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310235(3-[7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphen...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 30 [57-517](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM592760(2-chloro-N-(8-cyano-8- azabicyclo[3.2.1]octan-2-yl...)
Affinity DataIC50:  10nMAssay Description:USP30 inhibition was tested with recombinant human USP30 using the fluorescent substrate Ubiquitin-Rhodamine 110 (UBPBio) in 1536-well format. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50393333(CHEMBL2151050)
Affinity DataIC50:  10nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM515895(2-(5-Chloro-2- cyclopropyl-3- ((5-methoxy-3,4- dih...)
Affinity DataIC50:  10nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50393348(CHEMBL2152139)
Affinity DataIC50:  11nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310214(2-(3-Bromophenyl)-7-(3'-cyclopropylmethoxy-4'-difl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380414(CHEMBL2018467)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380417(CHEMBL2018485)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced tango beta-arrestin recruitment preincubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50380437(CHEMBL2018474)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at S1P1 receptor expressed in HEK293 cells assessed as inhibition of S1P-induced cAMP response after 90 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50269714(CHEMBL4092264)
Affinity DataIC50:  15nMAssay Description:Inhibition of ENPP2 in human plasma using LPC as substrate preincubated for 15 mins followed by substrate addition measured after 3 hrs by LC-MS/MS a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393339(CHEMBL2152131)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 30 [57-517](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM592741((3S)-6-chloro-N-((1R,2R,4S)-7-cyano-7- azabicyclo[...)
Affinity DataIC50:  17nMAssay Description:USP30 inhibition was tested with recombinant human USP30 using the fluorescent substrate Ubiquitin-Rhodamine 110 (UBPBio) in 1536-well format. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50393360(CHEMBL2152250)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393342(CHEMBL2152252)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
LigandPNGBDBM50393335(CHEMBL2152127)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310226(Acetic acid 3-[7-(3'-cyclopropylmethoxy-4'-difluor...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393334(CHEMBL2152126)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
LigandPNGBDBM50393353(CHEMBL2152144)
Affinity DataIC50:  18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Chungnam National University

Curated by ChEMBL
LigandPNGBDBM50458123(CHEMBL4215710)
Affinity DataIC50:  19nMAssay Description:Inhibition of human ENPP2 using FS3 as substrate measured every 5 mins for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50393354(CHEMBL2152145)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Korea Research Institute Of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50310210(7-(3'-Cyclopentyloxy-4'-methoxyphenyl)-2-(3-chloro...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUbiquitin carboxyl-terminal hydrolase 30 [57-517](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM592645((3S)-6-chloro-N-((1R,2R,4S)-7-cyano-7- azabicyclo[...)
Affinity DataIC50:  20nMAssay Description:USP30 inhibition was tested with recombinant human USP30 using the fluorescent substrate Ubiquitin-Rhodamine 110 (UBPBio) in 1536-well format. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50393364(CHEMBL2152256)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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