TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 0.430nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
Affinity DataKi: <0.5nMAssay Description:Inhibition of MPS1 (510 to 857 residues) catalytic domain (unknown origin) expressed in Escherichia coli after 15 mins by mass-spectrometry analysisMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 0.780nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 0.850nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 0.910nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma 1 receptor in rat brain membranes by competitive binding assayMore data for this Ligand-Target Pair
TargetEmopamil-binding protein-like(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 1.70nMAssay Description:Binding affinity to emopamil binding proteinMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 1.90nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.60nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetEmopamil-binding protein-like(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 2.80nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetEmopamil-binding protein-like(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 3.90nMAssay Description:Binding affinity to emopamil binding protein (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 4.20nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Curated by ChEMBL
Affinity DataKi: 5nMAssay Description:Displacement of (+)-[3H]pentazocine from sigma1 receptor in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 5.20nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 6nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 6.10nMAssay Description:Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me...More data for this Ligand-Target Pair
Affinity DataKi: 6.10nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Sun Yat-Sen University
Curated by ChEMBL
Sun Yat-Sen University
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Binding affinity to PDE9A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 7nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 8.10nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 8.30nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.70nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 9.70nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 11nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 11.2nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12.3nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 12.6nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [3H]4-(benzyloxy)-1-(1-(2-(pyrrolidin-1-yl)ethyl)-1H-indazol-5-yl)pyridin-2(1H)-one from MCH-1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Evaluation of the affinity of compounds for the human MCH-1 receptor was accomplished using 4-(3,4,5-tritritiumbenzyloxy)-1-(1-(2-(pyrrolidin-1-yl)et...More data for this Ligand-Target Pair