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Found 36 with Last Name = 'johannes' and Initial = 'c'
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259507((2S,3S,3aR,9bR)-2-(4-benzylpiperidine-1-carbonyl)-...)
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259496((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259498((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259500((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  1.60E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259495((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  2.00E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259508((2S,3S,3aR,9bR)-1-(3,4-dichlorobenzyl)-2-(4-(4-flu...)
Affinity DataKi:  2.20E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259497((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259499((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  3.00E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259503((2R,3R,3aS,9bS)-N-((S)-1-benzylpyrrolidin-3-yl)-1-...)
Affinity DataKi:  4.10E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259501((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  4.30E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259509((2S,3S,3aR,9bR)-2-(4-benzylpiperidine-1-carbonyl)-...)
Affinity DataKi:  5.20E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259504((2R,3R,3aS,9bS)-1-(cyclohexylmethyl)-N-(2,3-dihydr...)
Affinity DataKi:  5.40E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259499((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  5.70E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259495((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  5.70E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259497((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  6.00E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259496((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  6.60E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259510((2S,3S,3aR,9bR)-2-(4-(4-fluorophenyl)piperidine-1-...)
Affinity DataKi:  6.80E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259505((2R,3R,3aS,9bS)-N-((R)-1-benzylpyrrolidin-3-yl)-1-...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259500((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  7.80E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259506((2R,3R,3aS,9bS)-1-(cyclohexylmethyl)-3-(hydroxymet...)
Affinity DataKi:  8.40E+3nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259498((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259502((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi:  1.40E+4nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-2 (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259507((2S,3S,3aR,9bR)-2-(4-benzylpiperidine-1-carbonyl)-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259510((2S,3S,3aR,9bR)-2-(4-(4-fluorophenyl)piperidine-1-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259509((2S,3S,3aR,9bR)-2-(4-benzylpiperidine-1-carbonyl)-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259508((2S,3S,3aR,9bR)-1-(3,4-dichlorobenzyl)-2-(4-(4-flu...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259502((1R,9S,10S,11S)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259503((2R,3R,3aS,9bS)-N-((S)-1-benzylpyrrolidin-3-yl)-1-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259504((2R,3R,3aS,9bS)-1-(cyclohexylmethyl)-N-(2,3-dihydr...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259505((2R,3R,3aS,9bS)-N-((R)-1-benzylpyrrolidin-3-yl)-1-...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259506((2R,3R,3aS,9bS)-1-(cyclohexylmethyl)-3-(hydroxymet...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Infinity Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50259501((1S,9R,10R,11R)-12-[4-(4-Chloro-phenyl)-5-phenyl-t...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescently-tagged BH3 peptide from Bcl-XL (unknown origin) by chemiluminescent nitrogen detection methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50242325(CHEMBL4072295)
Affinity DataKd:  21nMAssay Description:Binding affinity to KRAS G12D mutant (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50561645(CHEMBL4760058)
Affinity DataKd:  430nMAssay Description:Binding affinity to KRAS G12D mutant (unknown origin) using FAM-labelled peptide as substrate in absence of Tween20 by fluorescence polarization assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50561645(CHEMBL4760058)
Affinity DataKd:  430nMAssay Description:Binding affinity to wild type KRAS (unknown origin) using FAM-labelled peptide as substrate in absence of Tween20 by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50242325(CHEMBL4072295)
Affinity DataKd:  16nMAssay Description:Binding affinity to KRAS G12D mutant (unknown origin) using FAM-labelled peptide as substrate in presence of Tween20 by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed