TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity to human P2X7R assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Binding affinity to human MAO-B assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 15nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKi: 19nM ΔG°: -44.1kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKi: 21nM ΔG°: -43.8kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 23nM ΔG°: -43.6kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 24nM ΔG°: -43.5kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 32nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataKi: 41nMAssay Description:Inhibition of ATX lysoPLD (unknown origin) using 18:1 LPC as substrate assessed as reduction in choline release by HVA fluorescence based analysisMore data for this Ligand-Target Pair
Affinity DataKi: 45nM ΔG°: -41.9kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Binding affinity to human melatonin MT1 assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 112nM ΔG°: -39.7kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 155nM ΔG°: -38.9kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 250nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 460nM ΔG°: -36.2kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 464nM ΔG°: -36.1kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 511nM ΔG°: -35.9kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 970nMAssay Description:Reversible inhibition of MAO-B in Wistar rat assessed as inhibition constant followed by using clorgyline as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 6.00E+3nM ΔG°: -29.8kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 7.30E+3nMAssay Description:Binding affinity to full length human CYP46A1 expressed in Escherichia coli DH5alpha as cholesterol-24 hydroxylation using cholesterol as substrate i...More data for this Ligand-Target Pair
Affinity DataKi: 1.07E+4nM ΔG°: -28.4kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
Affinity DataKi: 5.75E+4nM ΔG°: -24.2kJ/molepH: 5.5 T: 2°CAssay Description:Fluorescence was monitored on a SPEX Fluorolog-2 spectrofluorometer with the excitation and emission wavelengths set at 380 and 440 nm, respectively....More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Harvard Medical School
Curated by ChEMBL
Harvard Medical School
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3 kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair