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Found 3974 with Last Name = 'jung' and Initial = 's'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  0.00230nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220995(CHEMBL77788)
Affinity DataKi:  0.0190nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221005(CHEMBL75684)
Affinity DataKi:  0.0420nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220998(CHEMBL76382)
Affinity DataKi:  0.0460nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221003(CHEMBL432348)
Affinity DataKi:  0.0690nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220997(CHEMBL78237)
Affinity DataKi:  0.0920nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221006(CHEMBL77358)
Affinity DataKi:  0.146nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220999(CHEMBL77745)
Affinity DataKi:  0.336nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Universitat Jaume I

Curated by ChEMBL
LigandPNGBDBM50201259(CHEMBL3907022)
Affinity DataKi:  0.440nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574836(CHEMBL4871105)
Affinity DataKi:  0.450nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured at second inhibition step by fluorome...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50201259(CHEMBL3907022)
Affinity DataKi:  0.490nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 15 to 30 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220996(CHEMBL76635)
Affinity DataKi:  1.20nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574837(CHEMBL4855902)
Affinity DataKi:  1.5nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured at second inhibition step by fluorome...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221004(CHEMBL77999)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221001(CHEMBL76257)
Affinity DataKi:  2nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Sungshin Women'S University

Curated by ChEMBL
LigandPNGBDBM50206004((R)-1-(3-(3-(3,4-dimethoxyphenyl)-4,5-dihydroisoxa...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Sungshin Women'S University

Curated by ChEMBL
LigandPNGBDBM50206002((R)-1-(bis(4-fluorophenyl)methyl)-4-(3-(3-(3,4-dim...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220993(CHEMBL78238)
Affinity DataKi:  2.30nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279827(2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-2,3-dihydr...)
Affinity DataKi:  2.40nM Kon:  0.000300M-1s-1 Koff:  1.40E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221007(CHEMBL80258)
Affinity DataKi:  2.70nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50159089(CHEMBL180523 | N,N-Dibutyl-2-[6,8-dichloro-2-(4-ch...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574818(CHEMBL4861941)
Affinity DataKi:  3nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.00200M-1s-1 Koff:  7.00E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279825((1R,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Compound was evaluated for binding inhibition against Prolyl Endopeptidase (PEP).More data for this Ligand-Target Pair
In DepthDetails Article
TargetProlyl endopeptidase(Mus musculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nM Kon:  0.000700M-1s-1 Koff:  2.30E+5s-1Assay Description:Compound was evaluated for the enzyme kinetic data (kon) for binding inhibition against Prolyl Endopeptidase (PEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM429243(jm5b01461, Compound 60)
Affinity DataKi:  3.10nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50045877(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Sungshin Women'S University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine receptor D2 long expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221002(CHEMBL306320)
Affinity DataKi:  3.5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50201212(CHEMBL3974129)
Affinity DataKi:  4.20nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 15 to 30 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50220994(CHEMBL77177)
Affinity DataKi: >5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574820(CHEMBL4863808)
Affinity DataKi:  5nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rattus norvegicus)
Lead Gene

Curated by ChEMBL
LigandPNGBDBM50221000(CHEMBL431962)
Affinity DataKi: >5nMAssay Description:Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Sungshin Women'S University

Curated by ChEMBL
LigandPNGBDBM50206003((S)-1-(3-(3-(3,4-dimethoxyphenyl)-4,5-dihydroisoxa...)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM429242(acs.jmedchem.1c00409_ST.4 | jm5b01461, Compound 59)
Affinity DataKi:  6nMAssay Description:This is a review article.More data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
Sungshin Women'S University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]YM-09151-2 from human cloned dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50201213(CHEMBL3934979)
Affinity DataKi:  6.5nMAssay Description:Inhibition of Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 15 to 30 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574819(CHEMBL4860770)
Affinity DataKi:  7nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574821(CHEMBL4864383)
Affinity DataKi:  7nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
University Of Bonn

LigandPNGBDBM429296(jm5b01461, Compound 116)
Affinity DataKi:  7.5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Universitat Jaume I

Curated by ChEMBL
LigandPNGBDBM50201259(CHEMBL3907022)
Affinity DataKi:  8nMAssay Description:Inhibition of human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  8.90nMAssay Description:Displacement of [3H]PK11195 from TSPO in Sprague-Dawley rat cerebral cortex membranes after 60 mins by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50592132(CHEMBL5172863)
Affinity DataKi:  9nMAssay Description:Irreversible inhibition of Trypanosoma brucei rhodesiense rhodesain assessed as inhibition constant using Cbz-Phe-Arg-AMC as fluorogenic substrate by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574817(CHEMBL4855613)
Affinity DataKi:  9nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Defence

Curated by ChEMBL
LigandPNGBDBM10624(1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-on...)
Affinity DataKi:  10nMAssay Description:Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50592133(CHEMBL5208143)
Affinity DataKi:  10nMAssay Description:Irreversible inhibition of Trypanosoma brucei rhodesiense rhodesain assessed as inhibition constant using Cbz-Phe-Arg-AMC as fluorogenic substrate by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50574822(CHEMBL4874291)
Affinity DataKi:  10nMAssay Description:Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured using Dixon equation by fluorometric ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataKi:  10nMAssay Description:Irreversible inhibition of human Cathepsin L assessed as inhibition constant using Cbz-Phe-Arg-AMC as fluorogenic substrate by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCruzipain(Trypanosoma cruzi)
Universitat Jaume I

Curated by ChEMBL
LigandPNGBDBM50201212(CHEMBL3974129)
Affinity DataKi:  11nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Johannes Gutenberg University

Curated by ChEMBL
LigandPNGBDBM50201259(CHEMBL3907022)
Affinity DataKi:  11nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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