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Found 34 with Last Name = 'karapetyan' and Initial = 'g'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Rostock

Curated by ChEMBL
LigandPNGBDBM50326901(3-(4-fluorophenethylamino)-1-methyl-4-(2-methyl-1H...)
Affinity DataIC50:  53nMAssay Description:Inhibition of GSK3beta after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Rostock

Curated by ChEMBL
LigandPNGBDBM8296(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Affinity DataIC50:  92nMAssay Description:Inhibition of GSK3beta after 30 mins by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331157(1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-naphthyridin...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331158(5-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoquino...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331156(5-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)isoquino...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331153(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331166(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331166(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331166(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331166(1-methyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrol...)
Affinity DataIC50: <1.00E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331165(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-naphthyridin...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331164(5-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-nap...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331163(1-(2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2,6-nap...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331162(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331159(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331162(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331153(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331152(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)cinnoline | US972...)
Affinity DataIC50:  5.50E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331154(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinolin-1-yla...)
Affinity DataIC50:  5.50E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50:  5.50E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331160(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Affinity DataIC50:  5.50E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331159(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Affinity DataIC50:  5.50E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331160(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331160(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Affinity DataIC50:  5.50E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331159(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Affinity DataIC50:  5.50E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331153(5-(1H-pyrrolo[2,3-b]pyridin-3-yl)isoquinoline | US...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331159(3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrrolo[2,3-c...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM331160(1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-pyrr...)
Affinity DataIC50:  5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent