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Found 52 with Last Name = 'kassick' and Initial = 'aj'
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataIC50:  0.0600nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  0.75nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Allegheny General Hospital

Curated by ChEMBL
LigandPNGBDBM50590365(CHEMBL5197033)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at human MOR expressed in CHO-K1 cells assessed as reduction in fentanyl induced cAMP production incubated for 30 mins by Lance u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataIC50:  9.5nMAssay Description:Displacement of [125I]substance P from human NK1 receptor expressed in CHO cells in presence of human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Allegheny General Hospital

Curated by ChEMBL
LigandPNGBDBM50590364(CHEMBL5180599)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human MOR expressed in CHO-K1 cells assessed as reduction in fentanyl induced cAMP production incubated for 30 mins by Lance u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Allegheny General Hospital

Curated by ChEMBL
LigandPNGBDBM50000788((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human MOR expressed in CHO-K1 cells assessed as reduction in fentanyl induced cAMP production incubated for 30 mins by Lance u...More data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTranscription factor Dp-2(Homo sapiens)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataIC50:  1.80E+3nMAssay Description:Binding affinity to DP2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataIC50:  2.40E+3nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50277511(3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-Bis(trifluoromet...)
Affinity DataIC50:  2.40E+3nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  2.50E+3nMAssay Description:Binding affinity to human NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  7.20E+3nMAssay Description:Binding affinity to human NK2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged PRAK expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  4.10E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataIC50: >5.00E+4nMAssay Description:Reversible inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50437205(CHEMBL2402572)
Affinity DataIC50:  6.10E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor Dp-2(Homo sapiens)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataIC50: >8.60E+4nMAssay Description:Binding affinity to DP2 receptor (unknown origin) in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  2.86E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 6 alpha1/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  26nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 9 alpha2/beta1/gamma3 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit gamma-1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  39nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 10 alpha2/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  23nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 11 alpha2/beta2/gamma2 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246123(CHEMBL4066431)
Affinity DataEC50:  8.10E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246124(CHEMBL4097407)
Affinity DataEC50:  2.90E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246125(CHEMBL4078587)
Affinity DataEC50:  2.60E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246126(CHEMBL4077813)
Affinity DataEC50:  8.50E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246133(CHEMBL4064094)
Affinity DataEC50:  6.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246141(CHEMBL4093406)
Affinity DataEC50:  8.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50246142(CHEMBL4071905)
Affinity DataEC50:  7.40E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246143(CHEMBL4071467)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246144(CHEMBL4066650)
Affinity DataEC50:  800nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246153(CHEMBL4071158)
Affinity DataEC50:  29nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246154(CHEMBL4091973)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246155(CHEMBL4078549)
Affinity DataEC50:  32nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246156(CHEMBL4104303)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246157(CHEMBL4071175)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50246158(CHEMBL3393128)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50195475(CHEMBL3393127)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  40nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 4 alpha1/beta2/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 8 alpha2/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-AMP-activated protein kinase subunit beta-2(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 12 alpha2/beta2/gamma3 expressed in baculovirus infected Sf21 cells assessed as pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246159(CHEMBL4090039)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50246160(CHEMBL4061943)
Affinity DataEC50:  3.60E+4nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246161(CHEMBL4088692)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of human PXR transfected in human hepatoma cells assessed as induction of CYP3A4 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 1 alpha1/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246171(CHEMBL4066628)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 7 alpha2/beta1/gamma1 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50246120(CHEMBL4082745)
Affinity DataEC50:  21nMAssay Description:Agonist activity at human recombinant phosphorylated AMPK complex 2 alpha1/beta1/gamma2 expressed in baculovirus infected Sf21 cells assessed as phos...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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