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Found 138 with Last Name = 'kauffman' and Initial = 'gs'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24855(4-{1,2-dihydrospiro[indole-3,4'-piperidine]}-7H-py...)
Affinity DataIC50:  2.40nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24848(5-fluoro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  3.10nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24847(5-chloro-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24853(1-{5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  4.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24846(1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-dihydrospi...)
Affinity DataIC50:  5.30nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24852(1-{5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-d...)
Affinity DataIC50:  5.80nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209338(CHEMBL231102 | N-(2,6-difluorophenyl)-4-(2-methyl-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526389(CHEMBL4450081)
Affinity DataIC50:  10nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526400(CHEMBL4553437)
Affinity DataIC50:  11nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526390(CHEMBL4462401)
Affinity DataIC50:  11nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526389(CHEMBL4450081)
Affinity DataIC50:  12nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526397(CHEMBL4440024)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24849(1'-methyl-1-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}-1,2-...)
Affinity DataIC50:  12.7nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209370(4-(2-methyl-4-(6-(methylamino)pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  13nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526400(CHEMBL4553437)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209341(4-(2-methyl-4-(6-(2-morpholinoethylamino)pyrido[3,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209340(4-(2-methyl-4-(6-(4-methylpiperazin-1-yl)pyrido[3,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209351(CHEMBL230575 | N-(3-(4-(4-(1-(3,3-dimethylbutanoyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209338(CHEMBL231102 | N-(2,6-difluorophenyl)-4-(2-methyl-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526391(CHEMBL4529391)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526391(CHEMBL4529391)
Affinity DataIC50:  18nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209372(CHEMBL230891 | N-tert-butyl-3-(4-(6-(3-(2-methoxya...)
Affinity DataIC50:  18nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209371(CHEMBL228276 | cyclopentyl(4-(2-methyl-4-(6-morpho...)
Affinity DataIC50:  18nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209366(CHEMBL231101 | N-(2,6-difluorophenyl)-4-(4-(6,7-di...)
Affinity DataIC50:  19nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209348(1-(4-(4-(6-(2-methoxyethoxy)quinazolin-4-ylamino)-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526397(CHEMBL4440024)
Affinity DataIC50:  19nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209368(CHEMBL398172 | N-(2,6-difluorophenyl)-4-(4-(6-(dim...)
Affinity DataIC50:  20nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209368(CHEMBL398172 | N-(2,6-difluorophenyl)-4-(4-(6-(dim...)
Affinity DataIC50:  21nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209353(4-(2-methyl-4-(6-morpholinopyrido[3,4-d]pyrimidin-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209352(3,3-dimethyl-1-(4-(2-methyl-4-(6-morpholinopyrido[...)
Affinity DataIC50:  23nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209342(4-(4-(6-(3-(2-methoxyacetamido)prop-1-ynyl)quinazo...)
Affinity DataIC50:  23nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209353(4-(2-methyl-4-(6-morpholinopyrido[3,4-d]pyrimidin-...)
Affinity DataIC50:  24nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209364(CHEMBL231302 | N-(2,6-difluorophenyl)-4-(2-methyl-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526383(CHEMBL4575847)
Affinity DataIC50:  26nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209359(CHEMBL231205 | N-(2,6-difluorophenyl)-4-(4-(6-(2-m...)
Affinity DataIC50:  27nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209363(CHEMBL228275 | cyclopentyl(4-(4-(6-(2-methoxyethox...)
Affinity DataIC50:  29nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209370(4-(2-methyl-4-(6-(methylamino)pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209372(CHEMBL230891 | N-tert-butyl-3-(4-(6-(3-(2-methoxya...)
Affinity DataIC50:  30nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526388(CHEMBL4518496)
Affinity DataIC50:  32nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526390(CHEMBL4462401)
Affinity DataIC50:  32nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209359(CHEMBL231205 | N-(2,6-difluorophenyl)-4-(4-(6-(2-m...)
Affinity DataIC50:  33nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209371(CHEMBL228276 | cyclopentyl(4-(2-methyl-4-(6-morpho...)
Affinity DataIC50:  33nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty acid synthase(Homo sapiens (Human))
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526382(CHEMBL4466578)
Affinity DataIC50:  33nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209360(CHEMBL230255 | N-(3-methyl-4-(1-methylpiperidin-4-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209358(4-(2-methyl-4-(6-(pyrrolidin-1-yl)pyrido[3,4-d]pyr...)
Affinity DataIC50:  36nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24845(5-chloro-4-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-5...)
Affinity DataIC50:  42nMpH: 7.5 T: 2°CAssay Description:A fluorescence polarization IMAP type assay is used. After a 90 min incubation of reaction mixtures containing enzyme, substrate, and inhibitor, IMAP...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209363(CHEMBL228275 | cyclopentyl(4-(4-(6-(2-methoxyethox...)
Affinity DataIC50:  44nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209333(CHEMBL231204 | N-(2,6-difluorophenyl)-4-(4-(6-meth...)
Affinity DataIC50:  46nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209346(4-(4-(6-(dimethylamino)pyrido[3,4-d]pyrimidin-4-yl...)
Affinity DataIC50:  48nMAssay Description:Inhibition of erbB2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209347(CHEMBL230574 | N-(3-{4-[4-(1-Cyclobutanecarbonyl-p...)
Affinity DataIC50:  51nMAssay Description:Inhibition of erbB2 in NH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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