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Found 340 with Last Name = 'kaul' and Initial = 'r'
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM77064(US9695197, 4)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205418(US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...)
Affinity DataKi:  0.300nM ΔG°:  -54.4kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205418(US9243020, (3aR,5R,6S,7R,7aR)-2-(ethylamino)-5-(hy...)
Affinity DataKi:  0.300nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513934(CHEMBL4443587)
Affinity DataKi:  0.360nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  0.400nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  0.410nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataKi:  0.5nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513931(CHEMBL4444446)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205423(US9243020, 17 | US9815861, Example 17)
Affinity DataKi:  0.550nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267947((3aR,5R,6S,7R,7aR)-5- ((cyclopentylamino)methyl)-2...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataKi:  1.30nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267944((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267946((3aR,5R,6S,7R,7aR)-5- ((cyclobutylamino)methyl)-2-...)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM77047(US9695197, 3)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataKi:  1.40nM ΔG°:  -50.5kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataKi:  1.40nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataKi:  1.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataKi:  1.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285821((6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-...)
Affinity DataKi:  2.10nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285821((6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-...)
Affinity DataKi:  2.10nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50323697((3AR,5R,6S,7R,7AR)-2-(ETHYLAMINO)-5-(HYDROXYMETHYL...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of recombinant human OGA expressed in Escherichia coli assessed as inhibitory constant using 4-MUGlcNAc as substrate incubated for 20 mins...More data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205425(US9243020, 20 | US9815861, Example 20)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285819((6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol...)
Affinity DataKi:  2.60nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM285819((6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol...)
Affinity DataKi:  2.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267936(((3aR,5R,6S,7R,7aR)-6,7-dihydroxy- 2-(methylamino)...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267938((3aR,5R,6S,7R,7aR)-2- (methylamino)-5- ((methylami...)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM141965(US8927507, 16)
Affinity DataKi:  2.80nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205422(US9243020, 9 | US9815861, Example 9)
Affinity DataKi:  3nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267964((3aR,5R,6S,7R,7aR)-5-(((2- hydroxyethyl)amino)meth...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM70885(US9695197, 2)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM70719(US9695197, 1)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513947(CHEMBL4545886)
Affinity DataKi:  3.30nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267943((3aR,5R,6S,7R,7aR)-5-(((2- methoxyethyl)amino)meth...)
Affinity DataKi:  3.30nM ΔG°:  -48.4kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267941((3aR,5R,6S,7R,7aR)-5- ((ethylamino)methyl)-2- (met...)
Affinity DataKi:  3.70nM ΔG°:  -48.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267942((3aR,5R,6S,7R,7aR)-5- ((allylamino)methyl)-2- (met...)
Affinity DataKi:  3.80nM ΔG°:  -48.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513960(CHEMBL4561925)
Affinity DataKi:  5.30nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267965(2-((((3aR,5R,6S,7R,7aR)-6,7- dihydroxy-2-(methylam...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267937((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((isopropylam...)
Affinity DataKi:  5.40nM ΔG°:  -47.2kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513955(CHEMBL4483089)
Affinity DataKi:  5.5nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM50513957(CHEMBL4456515)
Affinity DataKi:  5.60nMAssay Description:Inhibition of recombinant human OGAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267939((3aR,5R,6S,7R,7aR)-2-(ethylamino)- 5-((methylamino...)
Affinity DataKi:  5.60nM ΔG°:  -47.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205424(US9243020, 19 | US9815861, Example 19)
Affinity DataKi:  5.70nM ΔG°:  -47.1kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
TargetProtein O-GlcNAcase(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM205424(US9243020, 19 | US9815861, Example 19)
Affinity DataKi:  5.70nMAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267963((3aR,5R,6S,7R,7aR)-5-(((3- hydroxypropyl)amino)met...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267945((3aR,5R,6S,7R,7aR)-5- ((cyclopropylamino)methyl)-2...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target4-hydroxy-2-oxoglutarate aldolase, mitochondrial(Homo sapiens (Human))
Alectos Therapeutics

US Patent
LigandPNGBDBM267962((3aR,5R,6S,7R,7aR)-2- (methylamino)-5-(((tetrahydr...)
Affinity DataKi:  6.5nM ΔG°:  -46.7kJ/molepH: 7.0 T: 2°CAssay Description:Enzymatic reactions were carried out in a reaction containing 50 mM NaH2PO4, 100 mM NaCl and 0.1% BSA (pH 7.0) using 2 mM 4-Methylumbelliferyl N-acet...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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