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Found 337 with Last Name = 'kester' and Initial = 'ja'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataKi:  0.0340nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050976(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataKi:  0.0690nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050964(4-[1-Benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenes...)
Affinity DataKi:  0.130nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  0.170nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  0.430nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050964(4-[1-Benzo[1,3]dioxol-5-yl-2-(4-isopropyl-benzenes...)
Affinity DataKi:  5.40nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051012(4-tert-Butyl-N-[6-(3-hydroxy-propyl)-5-(2-methoxy-...)
Affinity DataKi:  6.5nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  14.7nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50034435(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Affinity DataKi:  48nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050970((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataKi:  63nMAssay Description:Inhibitory activity of the compound against human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050976(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataKi:  139nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50034267(3-(benzo[d][1,3]dioxol-5-yl)-5-hydroxy-5-(4-methox...)
Affinity DataKi:  139nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051012(4-tert-Butyl-N-[6-(3-hydroxy-propyl)-5-(2-methoxy-...)
Affinity DataKi:  343nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50034435(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibitory activity of the compound against human Endothelin B receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050976(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.110nMAssay Description:Radioligand binding selectivity of the compound to human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050975((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-propy...)
Affinity DataIC50:  0.220nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051007((2R,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  0.310nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050976(4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2...)
Affinity DataIC50:  0.360nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051022((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-{[bis-(3-meth...)
Affinity DataIC50:  0.430nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050998(4-Benzo[1,3]dioxol-5-yl-1-(1-dibutylcarbamoyl-ethy...)
Affinity DataIC50:  0.460nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050980((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-dipropylcarba...)
Affinity DataIC50:  0.550nMAssay Description:Radioligand binding selectivity of the compound to human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051005((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-dipentylcarba...)
Affinity DataIC50:  0.560nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050975((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-propy...)
Affinity DataIC50:  0.810nMAssay Description:Radioligand binding selectivity of the compound to human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050982((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-pheny...)
Affinity DataIC50:  0.810nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050978((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-ethyl...)
Affinity DataIC50:  0.850nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050980((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-dipropylcarba...)
Affinity DataIC50:  1.23nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050056(2-[(R)-1-[(S)-2-(3-Cyclohexyl-3-methyl-ureido)-4-m...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050989((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(isobutyl-me...)
Affinity DataIC50:  1.88nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050967((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-{[bis-(2-meth...)
Affinity DataIC50:  4.45nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050063(2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4...)
Affinity DataIC50:  4.60nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050996((2S,3R,4S)-4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbam...)
Affinity DataIC50:  4.62nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050987((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-methy...)
Affinity DataIC50:  4.71nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050987((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(butyl-methy...)
Affinity DataIC50:  4.88nMAssay Description:Radioligand binding selectivity of the compound to human Endothelin A receptor in chinese hamster ovary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050033(5-Methyl-2-((R)-2-(1-methyl-1H-indol-3-yl)-1-{(S)-...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050985((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-ph...)
Affinity DataIC50:  5.78nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050026(2-[(R)-1-{(S)-2-[(2,3-Dihydro-indole-1-carbonyl)-a...)
Affinity DataIC50:  5.90nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050984((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-ph...)
Affinity DataIC50:  6.63nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050043(5-Methyl-2-{(R)-2-(1-methyl-1H-indol-3-yl)-1-[(S)-...)
Affinity DataIC50:  7.60nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051002((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(hexyl-methy...)
Affinity DataIC50:  7.61nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050973((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-(isobutylcarb...)
Affinity DataIC50:  8.20nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050058(2-[(R)-1-((S)-2-Cyclohexylcarbamoyloxy-4-methyl-pe...)
Affinity DataIC50:  9.30nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050047(2-[(R)-1-[(S)-2-(3-Cyclohexyl-ureido)-4-methyl-pen...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050047(2-[(R)-1-[(S)-2-(3-Cyclohexyl-ureido)-4-methyl-pen...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050031(5-Methyl-2-{(R)-2-(1-methyl-1H-indol-3-yl)-1-[(S)-...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050999((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-[(diisobutylc...)
Affinity DataIC50:  16.2nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50051011((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-1-cyclopentylca...)
Affinity DataIC50:  16.2nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050064(2-[(R)-1-((S)-2-Cyclohexyloxycarbonyloxy-4-methyl-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was evaluated against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050032(2-[(R)-1-{(S)-2-[3-(2-Fluoro-phenyl)-ureido]-4-met...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050979((2S,3S,4R)-4-Benzo[1,3]dioxol-5-yl-2-(4-methoxy-ph...)
Affinity DataIC50:  17.2nMAssay Description:Inhibitory activity against the Endothelin A receptor of rat MMQ cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50050001(5-Methyl-2-((R)-2-(1-methyl-1H-indol-3-yl)-1-{(S)-...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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