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Found 441 with Last Name = 'kojima' and Initial = 'h'
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135288((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-...)
Affinity DataKi:  180nMAssay Description:Inhibitory activity of the compound against P. falciparum S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Plasmodium falciparum 3D7)
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataKi:  480nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50135289((1S,2R,3S,4R)-4-(6-Amino-2-fluoro-purin-9-yl)-cycl...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibitory activity of the compound against human S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50081472((2S,3S)-4-(6-Amino-purin-9-yl)-2,3-dihydroxy-butyr...)
Affinity DataKi:  8.80E+3nMAssay Description:Inhibition of human SAHHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50244094(9-[(10R,20S,30S,40R)-30,40-Epoxy-20-hydroxy-cyclop...)
Affinity DataKi:  1.24E+4nMAssay Description:Inhibition of human SAHHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
Gifu University

Curated by ChEMBL
LigandPNGBDBM50244095(9-[(10R,20S,30R,50R)-30,40-Epoxy-20-hydroxy-cyclop...)
Affinity DataKi:  2.03E+4nMAssay Description:Inhibition of human SAHHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119678((R)-5-Benzo[1,3]dioxol-5-yl-2-isopropylamino-7-(4-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119676((R)-5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2...)
Affinity DataIC50:  0.120nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119665(5-Benzo[1,3]dioxol-5-yl-2-but-3-enyl-7-(4-methoxy-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119671(5-Benzo[1,3]dioxol-5-yl-2-butyl-7-(4-methoxy-pheny...)
Affinity DataIC50:  0.210nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232782(CHEMBL4083975)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119663(5-Benzo[1,3]dioxol-5-yl-2-isobutyl-7-(4-methoxy-ph...)
Affinity DataIC50:  0.320nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119670(5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2-pro...)
Affinity DataIC50:  0.370nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232778(CHEMBL4062256)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PIM3 (1 to 326 end residues) expressed in baculovirus infected sf21 cells using S6K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232778(CHEMBL4062256)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232778(CHEMBL4062256)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of full length recombinant human N-terminal His-tagged PIM1 (1 to 313 end residues) expressed in baculovirus infected sf21 cells using S6K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119673((R)-5-Benzo[1,3]dioxol-5-yl-2-ethoxymethyl-7-(4-me...)
Affinity DataIC50:  0.510nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119662((R)-5-Benzo[1,3]dioxol-5-yl-2-(3-hydroxy-propyl)-7...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232779(CHEMBL4060711)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50499276(CHEMBL3735861)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PIM3 (unknown origin) using FL-Peptide 1 (5-FAM-AKRRRLSSLRA-COOH) substrate incubated for 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50:  0.800nMAssay Description:Functional inhibition of ET-1 induced [Ca2+] increase in human Girardi heart (hGH) cells, which express Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284769((S)-2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{(S)-2-cycl...)
Affinity DataIC50:  0.810nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50051385(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-cyclopropyl-...)
Affinity DataIC50:  0.810nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)
Affinity DataIC50:  0.840nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232780(CHEMBL4061176)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PIM3 (1 to 326 end residues) expressed in baculovirus infected sf21 cells using S6K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119674((R)-5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2...)
Affinity DataIC50:  0.920nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051394(2-[(R)-2-{2-Cyclopropyl-2-[((2R,6S)-2,6-dimethyl-p...)
Affinity DataIC50:  1nMAssay Description:Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50051385(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-cyclopropyl-...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity towards Endothelin B receptor in human girardi heart cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50499277(CHEMBL3735633)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PIM3 (unknown origin) using FL-Peptide 1 (5-FAM-AKRRRLSSLRA-COOH) substrate incubated for 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232785(CHEMBL4074201)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284774(3-((R)-2-((S)-1-Carboxy-pentylcarbamoyl)-2-{2-[((2...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PIM3 (unknown origin) using FL-Peptide 1 (5-FAM-AKRRRLSSLRA-COOH) substrate incubated for 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50051410(2-((R)-3-(2-Chloro-1H-indol-3-yl)-2-{2-cyclopropyl...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232780(CHEMBL4061176)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of full length recombinant human N-terminal His-tagged PIM1 (1 to 313 end residues) expressed in baculovirus infected sf21 cells using S6K...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232780(CHEMBL4061176)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50284770((S)-2-((R)-3-(2-Cyano-1H-indol-3-yl)-2-{2-[((2R,6S...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50051403(2-((R)-3-(2-Cyano-1H-indol-3-yl)-2-{2-[((2S,6R)-2,...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119664((R)-5-Benzo[1,3]dioxol-5-yl-2-but-3-enyl-7-(4-meth...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50499281(CHEMBL3735816)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PIM3 (unknown origin) using FL-Peptide 1 (5-FAM-AKRRRLSSLRA-COOH) substrate incubated for 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50051406(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-[((2S,6R)-2,...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232786(CHEMBL4092704)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051404(CHEMBL312541 | [14-Cyclopentyl-11-cyclopropyl-8-(2...)
Affinity DataIC50:  1.80nMAssay Description:Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50051395(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-[((2S,6R)-2,...)
Affinity DataIC50:  1.90nMAssay Description:Binding affinity towards endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50499279(CHEMBL3735890)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PIM1 (unknown origin) by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051406(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-[((2S,6R)-2,...)
Affinity DataIC50:  1.90nMAssay Description:Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50119661(5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2-pen...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity of the compound against I-labeled ET-1 binding to Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50391948(CHEMBL2147767)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50232777(CHEMBL4102902)
Affinity DataIC50:  2nMAssay Description:Inhibition of PIM1 (unknown origin) using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 2 hrs by electrophoretic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50051425(2-((R)-3-(2-Bromo-1H-indol-3-yl)-2-{2-[((2S,6R)-2,...)
Affinity DataIC50:  2nMAssay Description:Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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