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Found 36 with Last Name = 'lagunin' and Initial = 'a'
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130714(1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-car...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from bovine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130714(1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-car...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130714(1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-car...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  100nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from human blood serumMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from rat cortex brain membraneMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130716(CHEMBL322069 | Thioacetic acid S-(2-phenylcarbamoy...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from bovine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130716(CHEMBL322069 | Thioacetic acid S-(2-phenylcarbamoy...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130716(CHEMBL322069 | Thioacetic acid S-(2-phenylcarbamoy...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130713(CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoy...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130716(CHEMBL322069 | Thioacetic acid S-(2-phenylcarbamoy...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Sciences And Technology Houari Boum£Di£Ne

Curated by ChEMBL
LigandPNGBDBM50375323(CHEMBL409288)
Affinity DataIC50:  7.94E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22340((5E)-5-[(3-nitrophenyl)methylidene]-2-(1,3-thiazol...)
Affinity DataIC50:  8.91E+4nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Sciences And Technology Houari Boum£Di£Ne

Curated by ChEMBL
LigandPNGBDBM50375324(CHEMBL411087)
Affinity DataIC50:  9.12E+4nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22337((5E)-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-...)
Affinity DataIC50:  9.95E+4nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130715(4-[(Hydroxy-phenethyl-phosphinoylmethyl)-amino]-bu...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130713(CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoy...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130715(4-[(Hydroxy-phenethyl-phosphinoylmethyl)-amino]-bu...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22343((5E)-5-[(2-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Affinity DataIC50:  1.15E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22335((5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-thiaz...)
Affinity DataIC50:  1.16E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22341((5E)-5-[(4-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Affinity DataIC50:  1.20E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22338((5E)-5-[(4-methoxyphenyl)methylidene]-2-(1,3-thiaz...)
Affinity DataIC50:  1.22E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Aristotle University

LigandPNGBDBM22342((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Affinity DataIC50:  1.25E+5nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22342((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Affinity DataIC50:  1.26E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Aristotle University

LigandPNGBDBM22339((5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thiazol...)
Affinity DataIC50:  1.41E+5nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Aristotle University

LigandPNGBDBM22335((5E)-5-[(4-hydroxyphenyl)methylidene]-2-(1,3-thiaz...)
Affinity DataIC50:  1.58E+5nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130713(CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoy...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130716(CHEMBL322069 | Thioacetic acid S-(2-phenylcarbamoy...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130713(CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoy...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from human blood serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Sciences And Technology Houari Boum£Di£Ne

Curated by ChEMBL
LigandPNGBDBM50375325(CHEMBL407153)
Affinity DataIC50:  2.51E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Aristotle University

LigandPNGBDBM22339((5E)-5-[(4-nitrophenyl)methylidene]-2-(1,3-thiazol...)
Affinity DataIC50:  2.51E+5nMpH: 7.4 T: 2°CAssay Description:The tested compounds were added to the reaction mixture with soybean lipoxygenase. Enzyme reaction was initiated by the addition of sodium linoleate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Aristotle University

LigandPNGBDBM22342((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Affinity DataIC50:  2.62E+5nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University Of Sciences And Technology Houari Boum£Di£Ne

Curated by ChEMBL
LigandPNGBDBM50375322(CHEMBL408423)
Affinity DataIC50:  2.69E+5nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130713(CHEMBL326801 | Thioacetic acid S-(2-benzylcarbamoy...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) from bovine kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130715(4-[(Hydroxy-phenethyl-phosphinoylmethyl)-amino]-bu...)
Affinity DataIC50:  2.00E+6nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Institute Of Biomedical Chemistry Of Russian Academy Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50130714(1-(3-Mercapto-propionyl)-6-methyl-piperidine-2-car...)
Affinity DataIC50:  2.00E+6nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP) from rat cortex brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed