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Found 2164 with Last Name = 'lambeir' and Initial = 'am'
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataKi:  0.0820nMAssay Description:Inhibition of DPP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50146972((S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1...)
Affinity DataKi:  0.0820nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  0.260nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  0.280nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135637(1-{(S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-car...)
Affinity DataKi:  0.340nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  0.450nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.87nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  1.90nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  2nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50434188(CHEMBL2385281 | US9346814, Cmpd No 2 Example 3)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of PKD2 ( assessed as residual activity at 1 uM ) by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  3.30nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135633((S)-2-[(S)-2-(5-Benzyloxymethyl-isoxazole-3-carbon...)
Affinity DataKi:  4nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Mus musculus (Mouse))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50434169(CHEMBL2385300 | US9346814, Cmpd No 22 Example 26)
Affinity DataKi:  4.10nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells using Ala-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substrate addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350167(CHEMBL1814741)
Affinity DataKi:  6.5nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135636((S)-2-[(S)-2-(5-Cyano-isoxazole-3-carbonyl)-pyrrol...)
Affinity DataKi:  7.5nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50110025(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM16152(2-({4-chloro-1-[(diaminomethylidene)amino]isoquino...)
Affinity DataKi:  10nMAssay Description:Inhibition of human uPA using S-2444 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; Moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135630((S)-2-[(S)-2-(5-Phenyl-isoxazole-3-carbonyl)-pyrro...)
Affinity DataKi:  15nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135635(2-[2-(Isothiazole-3-carbonyl)-pyrrolidine-1-carbon...)
Affinity DataKi:  16nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50228427((R)-N-[(S)-1-(4-guanidino-benzylcarbamoyl)-ethyl]-...)
Affinity DataKi:  16nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase IV(Porphyromonas gingivalis)
University Of Warwick

Curated by ChEMBL
LigandPNGBDBM11695((2S)-1-{2-[(3-hydroxyadamantan-1-yl)amino]acetyl}p...)
Affinity DataKi:  17nMAssay Description:Inhibition of Porphyromonas gingivalis N-terminal His-tagged DPP4 expressed in Escherichia coli using Gly-Pro-p-nitroanilide as substrate preincubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135634((S)-2-[(S)-2-(5-Trimethylsilanyl-isoxazole-3-carbo...)
Affinity DataKi:  19nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50231520((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Affinity DataKi:  20nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135632((S)-2-[(S)-2-(Isoxazole-3-carbonyl)-pyrrolidine-1-...)
Affinity DataKi:  36nMAssay Description:In vitro inhibitory activity determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50147422(3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic ...)
Affinity DataKi:  37nMAssay Description:Inhibition of human uPA using S-2444 as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
University Of Antwerp (Ua)

Curated by ChEMBL
LigandPNGBDBM50350175(CHEMBL1814749)
Affinity DataKi:  37nMAssay Description:Competitive inhibition of recombinant human DPP8 assessed as pNA release from Ala-Pro- p-nitroanilide substrate pre-incubated with enzyme for 15 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135636((S)-2-[(S)-2-(5-Cyano-isoxazole-3-carbonyl)-pyrrol...)
Affinity DataKi:  38nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138662(6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-a...)
Affinity DataKi:  40nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135632((S)-2-[(S)-2-(Isoxazole-3-carbonyl)-pyrrolidine-1-...)
Affinity DataKi:  72nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50110025(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Affinity DataKi:  100nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50050513((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...)
Affinity DataKi:  125nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  126nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM11464((2S,3S)-2-amino-3-methyl-1-(1,3-thiazolidin-3-yl)p...)
Affinity DataKi:  126nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138678(6-Carbamimidoyl-naphthalene-2-carboxylic acid (3,5...)
Affinity DataKi:  139nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118940((S)-1-((S)-2-Amino-propionyl)-pyrrolidine-2-carbon...)
Affinity DataKi:  200nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50366428(CHEMBL1793966)
Affinity DataKi:  218nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase IV (DPP IV)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Laboratory Of Medicinal Chemistry University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118943((2S,3S)-2-amino-3-methyl-1-(pyrrolidin-1-yl)pentan...)
Affinity DataKi:  218nMAssay Description:Inhibition of Dipeptidyl Peptidase IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  277nMAssay Description:Inhibitory activity of compound against Dipeptidylpeptidase II (DPP II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50118934((S)-2-Amino-1-thiazolidin-3-yl-propane-1-thione | ...)
Affinity DataKi:  277nMAssay Description:Inhibition of Dipeptidyl Peptidase II (Quiescent cell proline peptidase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataKi:  390nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataKi:  410nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataKi:  410nMAssay Description:Inhibition of uPA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM23891(3-amidinophenylalanine deriv., 35 | CHEMBL107955 |...)
Affinity DataKi:  490nMAssay Description:Inhibition of human plasma thrombin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50110025(CHEMBL158405 | N-(BENZYLSULFONYL)-D-SERYL-N-{4-[AM...)
Affinity DataKi:  540nMAssay Description:Inhibition of human plasma plasmin using pyroGlu-Pro-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50138670(6-Carbamimidoyl-naphthalene-2-carboxylic acid phen...)
Affinity DataKi:  631nMAssay Description:Inhibition of human uPA using pyroGlu-Gly-Arg-p-NA.HCl as substrate preincubated for 15 mins prior sustrate addition measured for 10 mins by spectrop...More data for this Ligand-Target Pair
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135631(3-[(S)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-ca...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi; Moderately activeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL
LigandPNGBDBM50135631(3-[(S)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-ca...)
Affinity DataKi: >1.00E+3nMAssay Description:In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruziMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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