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Found 60 with Last Name = 'lawton' and Initial = 'gr'
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255365((+/-)-cis-N1-((3S,4S)-4-((6-amino-4-methylpyridin-...)
Affinity DataKi:  14nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  15nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278676((+/-)-cis-N-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  53nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29234(CHEMBL481815 | US9090589, 6 | aminopyridine-pyrrol...)
Affinity DataKi:  85nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  100nM ΔG°:  -40.6kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21960(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
Affinity DataKi:  150nM ΔG°:  -39.6kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29235(aminopyridine-pyrrolidine, 7)
Affinity DataKi:  250nM ΔG°:  -38.3kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  300nM ΔG°:  -37.9kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29233(CHEMBL508014 | aminopyridine-pyrrolidine, 5)
Affinity DataKi:  388nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278744((+/-)-cis-6-((4-(2-(3-Fluorophenethoxy)ethylamino)...)
Affinity DataKi:  400nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain [D597N,M336V](Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM29234(CHEMBL481815 | US9090589, 6 | aminopyridine-pyrrol...)
Affinity DataKi:  1.20E+3nM ΔG°:  -34.4kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278745((+/-)-cis-2-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278744((+/-)-cis-6-((4-(2-(3-Fluorophenethoxy)ethylamino)...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255365((+/-)-cis-N1-((3S,4S)-4-((6-amino-4-methylpyridin-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278746((+/-)-cis-N-(2-(4-((6-Amino-4-methylpyridin-2-yl)-...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of rat recombinant nNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278676((+/-)-cis-N-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  5.40E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain [D597N,M336V](Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM29235(aminopyridine-pyrrolidine, 7)
Affinity DataKi:  6.10E+3nM ΔG°:  -30.3kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29232(3-({(3S,4S)-4-[(6-aminopyridin-2-yl)methyl]pyrroli...)
Affinity DataKi:  9.40E+3nM ΔG°:  -29.2kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278676((+/-)-cis-N-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  2.70E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50255365((+/-)-cis-N1-((3S,4S)-4-((6-amino-4-methylpyridin-...)
Affinity DataKi:  2.80E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278675((+/-)-cis-6-((4-(2-(3-Fluorophenethylamino)-ethoxy...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278744((+/-)-cis-6-((4-(2-(3-Fluorophenethoxy)ethylamino)...)
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain [D597N,M336V](Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM29233(CHEMBL508014 | aminopyridine-pyrrolidine, 5)
Affinity DataKi:  3.67E+4nM ΔG°:  -25.7kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain [D597N,M336V](Rattus norvegicus (rat))
University Of California Irvine

LigandPNGBDBM29232(3-({(3S,4S)-4-[(6-aminopyridin-2-yl)methyl]pyrroli...)
Affinity DataKi:  4.92E+4nM ΔG°:  -25.0kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278745((+/-)-cis-2-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  5.20E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278746((+/-)-cis-N-(2-(4-((6-Amino-4-methylpyridin-2-yl)-...)
Affinity DataKi:  7.70E+4nMAssay Description:Inhibition of mouse recombinant iNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21960(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
Affinity DataKi:  8.00E+4nM ΔG°:  -23.8kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29234(CHEMBL481815 | US9090589, 6 | aminopyridine-pyrrol...)
Affinity DataKi:  8.52E+4nM ΔG°:  -23.6kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29235(aminopyridine-pyrrolidine, 7)
Affinity DataKi:  9.52E+4nM ΔG°:  -23.3kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM22030((2S)-2-amino-N-[(1S)-3-amino-1-(aminocarbonyl)prop...)
Affinity DataKi:  1.07E+5nM ΔG°:  -23.0kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278746((+/-)-cis-N-(2-(4-((6-Amino-4-methylpyridin-2-yl)-...)
Affinity DataKi:  1.07E+5nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM21961((2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)...)
Affinity DataKi:  1.10E+5nM ΔG°:  -23.0kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50278745((+/-)-cis-2-(4-((6-Amino-4-methylpyridin-2-yl)-met...)
Affinity DataKi:  1.45E+5nMAssay Description:Inhibition of bovine recombinant eNOS expressed in Escherichia coli assessed as nitric oxide formation by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29232(3-({(3S,4S)-4-[(6-aminopyridin-2-yl)methyl]pyrroli...)
Affinity DataKi:  3.67E+5nM ΔG°:  -19.9kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM29233(CHEMBL508014 | aminopyridine-pyrrolidine, 5)
Affinity DataKi:  4.17E+5nM ΔG°:  -19.6kJ/molepH: 7.5 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279361((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by radioactivity assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50091805(2-amino-4,6-dimethylpyridine | 4,6-Dimethyl-pyridi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279392((+/-)-6-((4-(2-(3-fluorophenethylamino)ethoxy)pyrr...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human nNOS by radioactivity assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279361((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279394((+/-)-N-(4-((6-amino-4-methylpyridin-2-yl)methyl)p...)
Affinity DataIC50:  700nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279391((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279359((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279393((+/-)-6-((4-(2-(3-fluorophenethoxy)ethylamino)pyrr...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279394((+/-)-N-(4-((6-amino-4-methylpyridin-2-yl)methyl)p...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50279360((+/-)-N1-(4-((6-amino-4-methylpyridin-2-yl)methyl)...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of wild type rat nNOS by hemoglobin capture assayMore data for this Ligand-Target Pair
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