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Found 1099 with Last Name = 'le diguarher' and Initial = 't'
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50452012(CHEMBL2110187)
Affinity DataIC50:  1nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131944(2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354621(3-(6-{4-[(4-Hydroxyphenyl)(methyl)carbamoyl]-1,5-d...)
Affinity DataIC50:  1.5nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161571(US9108983, Example 386 | US9108983, Example 449)
Affinity DataIC50:  1.70nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131964(2-(4'-Chloro-biphenyl-4-ylsulfanyl)-5-(3-oxo-6,7,8...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131962(2-(4'-Chloro-biphenyl-4-sulfonyl)-5-(4-oxo-4H-benz...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354602(4-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...)
Affinity DataIC50:  1.80nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131953(2-(4'-Chloro-biphenyl-4-ylsulfanyl)-5-(4-oxo-4H-be...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161636(US9108983, Example 455)
Affinity DataIC50:  1.90nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354597(2-[2-(Dimethylamino)ethoxy]phenyl 6-{4-[(4-hydroxy...)
Affinity DataIC50:  2nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354648((1r,4r)-4-{[(tert-Butoxy)carbonyl]amino}cyclohexyl...)
Affinity DataIC50:  2nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161553(US9108983, Example 102)
Affinity DataIC50:  2nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM60412(US9108983, 445)
Affinity DataIC50:  2nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161536(US9108983, Example 68)
Affinity DataIC50:  2.10nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161578(US9108983, Example 393)
Affinity DataIC50:  2.10nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354619(3-(6-{4-[(4-Hydroxyphenyl)(methyl)carbamoyl]-1,5-d...)
Affinity DataIC50:  2.20nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354624(3-[2-(Dimethylcarbamoyl)ethyl]phenyl 6-{4-[(4-hydr...)
Affinity DataIC50:  2.20nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161610(US9108983, Example 427)
Affinity DataIC50:  2.20nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM161554(US9108983, Example 108 | US9108983, Example 448)
Affinity DataIC50:  2.40nMpH: 7.4Assay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM352978(3-{2-[2-(4-Cyanophenyl)acetyl]-7-[(3R)-3-methyl-1,...)
Affinity DataIC50:  2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354593(Phenyl 6-{4-[(4-hydroxyphenyl)(methyl)carbamoyl]-1...)
Affinity DataIC50:  2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Les Laboratoires Servier

US Patent
LigandPNGBDBM354623(2-[2-(Dimethylcarbamoyl)ethyl]phenyl 6-{4-[(4-hydr...)
Affinity DataIC50:  2.40nMAssay Description:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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