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Found 113 with Last Name = 'lee' and Initial = 'wa'
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021347(CHEMBL12391 | N-(3-Methyl-1-phenethyl-piperidin-4-...)
Affinity DataIC50:  1.30nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50017082((+)-trans-N-{1-[2-(4-Isothiocyanato-phenyl)-ethyl]...)
Affinity DataIC50:  6nMAssay Description:The ability of comp[ound to inhibit [3H]-DADL binding to the delta receptor of the NG108-15 cells at 10 min and 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185589((E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185586((E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50228233(CHEMBL3349043)
Affinity DataIC50:  20nMAssay Description:The ability of compound to inhibit [3H]-DADL binding to the delta receptor of the NG108-15 cells at 10 min and 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185592((E)-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihyd...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185601(CHEMBL380059)
Affinity DataIC50:  24nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataIC50:  25nMAssay Description:In vivo binding affinity to opioid receptor preparations from rat brainMore data for this Ligand-Target Pair
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM19264((4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human IMPDH1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185589((E)-2-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human IMPDH1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185592((E)-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihyd...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human IMPDH1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50228234(CHEMBL273222)
Affinity DataIC50:  60nMAssay Description:The ability of comp[ound to inhibit [3H]DADL binding to the delta receptor of the NG108-15 cells at 10 min and 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185595((E)-2-(N-(4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185586((E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydr...)
Affinity DataIC50:  71nMAssay Description:Inhibition of human IMPDH1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185585((E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihy...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185590((2-{[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185596((E)-5-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihy...)
Affinity DataIC50:  96nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185604((E)-2-((4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-di...)
Affinity DataIC50:  132nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185603((E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihy...)
Affinity DataIC50:  168nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185599((E)-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50:  246nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185587(7-hydroxy-5-methoxy-4-methyl-6-(3-methylbut-2-enyl...)
Affinity DataIC50:  254nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185594((E)-7-hydroxy-5-methoxy-6-(4-methoxy-3-methylbut-2...)
Affinity DataIC50:  273nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185588((E)-dimethyl 4-(4-hydroxy-6-methoxy-7-methyl-3-oxo...)
Affinity DataIC50:  289nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50228233(CHEMBL3349043)
Affinity DataIC50:  300nMAssay Description:The ability of comp[ound to inhibit [3H]-DADL binding to the delta receptor of the NG108-15 cells at 10 min and 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185598((2-{[(E)-4-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3...)
Affinity DataIC50:  498nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185602((E)-2-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-d...)
Affinity DataIC50:  499nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185600((1E,3E)-5-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-...)
Affinity DataIC50:  506nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185597((E)-2-(N-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,...)
Affinity DataIC50:  749nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185583((E)-2-(N-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,...)
Affinity DataIC50:  785nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185584((E)-(4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dih...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185591((E)-2-((4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInosine-5'-monophosphate dehydrogenase 2(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50185593((E)-diethyl 2-(4-(4-hydroxy-6-methoxy-7-methyl-3-o...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human IMPDH2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335553(CHEMBL1652466 | [({[2-(2-amino-6-oxo-6,9-dihydro-3...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335556(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335555(CHEMBL1652468 | {[({2-[2-amino-6-(cyclopropylamino...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human DNA polymerase beta by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335554(({[({[2-(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)e...)
Affinity DataIC50:  5.94E+4nMAssay Description:Inhibition of human DNA polymerase gamma by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335553(CHEMBL1652466 | [({[2-(2-amino-6-oxo-6,9-dihydro-3...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335555(CHEMBL1652468 | {[({2-[2-amino-6-(cyclopropylamino...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335556(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase subunit gamma-1(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50335556(CHEMBL1652469 | [({[({2-[2-amino-6-(cyclopropylami...)
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of human DNA polymerase gamma by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase beta preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA-directed RNA polymerase, mitochondrial(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human mitochondrial RNA polymerase after 30 mins in presence of [33P]GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50236025(CHEMBL2016761 | US11149049, No. C2)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of recombinant human DNA polymerase alpha preincubated with enzyme followed by addition of dATP/dGTP/TTP as substrate in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50027089(methyl 3-(11-hydroxy-15-methoxy-3-methyl-13-oxa-3-...)
Affinity DataEC50:  50nMAssay Description:The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50027086(3-[1-(2-Diethylamino-ethyl)-2-(4-ethoxy-benzyl)-1H...)
Affinity DataEC50:  800nMAssay Description:The binding affinity was evaluated against [3H]dalamid binding to rat brain membranes (Opioid receptor delta 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM50027087(2-Bromo-N-[1-(2-diethylamino-ethyl)-2-(4-ethoxy-be...)
Affinity DataEC50:  200nMAssay Description:The binding affinity was evaluated against [3H]dalamid binding to neuroblastoma X glioma hybrid cell NG108-15 (Opioid receptor delta 1)membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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