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Found 2372 with Last Name = 'levin' and Initial = 'ji'
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026212(CHEMBL1276185)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026207(CHEMBL1276170)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330925(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070257((R)-2-(3-Mercapto-2-oxo-propyl)-nonanoic acid ((S)...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070256((R)-2-((S)-2-Hydroxy-3-mercapto-propyl)-nonanoic a...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of matrix metalloproteinase-9, gelatinase-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330905(7-(2,6-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330924(7-(2-fluoro-4-((1S,4S)-5-methyl-2,5-diazabicyclo[2...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM11867(CHEMBL234350 | N-Hydroxy-4-{[(4-phenoxyphenyl)sulf...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50070228(2-(2-Mercapto-acetyl)-nonanoic acid ((S)-2,2-dimet...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity against gelatinase-B(MMP-9).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303103(1-(3-(3-(4-chloro-3-hydroxyphenyl)-2-(pyridin-4-yl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025947(CHEMBL1088438)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026014(CHEMBL1081284)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026023(CHEMBL1080931)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026022(CHEMBL1081283)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026210(CHEMBL1276196)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025938(CHEMBL1088439)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026013(CHEMBL1086882)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50025981(CHEMBL1088437)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026010(CHEMBL1087013)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026030(CHEMBL1080833)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026028(CHEMBL1087001)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026208(CHEMBL1276193)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026209(CHEMBL1276171)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026205(CHEMBL1276194)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026211(CHEMBL1276184)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026206(CHEMBL1276195)
Affinity DataIC50: <0.320nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330923(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)-7-(2,3,5,6-te...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330922(7-(2,5-difluoro-4-((1S,4S)-5-methyl-2,5-diazabicyc...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311985(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173235((S)-2-{4'-[(5-Bromo-4-methoxy-benzofuran-2-carbony...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118985(1-(Biphenyl-4-carbonyl)-4-(4-methoxy-benzenesulfon...)
Affinity DataIC50:  0.400nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50118983(1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-te...)
Affinity DataIC50:  0.400nMAssay Description:Concentration of the compound required in vitro to inhibit Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303123(CHEMBL570681 | ethyl 3-(3-(7-fluoro-1H-indazol-4-y...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303121(CHEMBL585144 | ethyl 3-(3-(7-chloro-1H-indazol-4-y...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303098(5-(7-(8-azabicyclo[3.2.1]octan-3-yl)-2-(pyridin-4-...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330921((1S,4S)-2-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)...)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Bos taurus)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50170292((S)-2-{4'-[(5-Methanesulfonylamino-benzofuran-2-ca...)
Affinity DataIC50:  0.430nMAssay Description:Inhibitory concentration against MMP-13 of bovine articular cartilage explantsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311989(7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)-...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311984(3-(7-(4-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-y...)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50106133(5-Bromo-2-{[4-(4-chloro-phenoxy)-benzenesulfonyl]-...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of Matrix metalloprotease-9.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311987(1-((1S,4S)-5-(4-(3-(4-fluoro-3-hydroxyphenyl)-2-(p...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303100(2-chloro-5-(7-(8-ethyl-8-azabicyclo[3.2.1]octan-3-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330920(3-(7-fluoro-1H-indazol-4-yl)-7-(4-((1S,4S)-5-methy...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50311986(5-(7-(4-((1S,4S)-5-ethyl-2,5-diazabicyclo[2.2.1]he...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human recombinant B-Raf expressed in Sf9 cells assessed as inhibition of Mek1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330919(3-(1H-indazol-4-yl)-7-(2-methyl-4-((1S,4S)-5-methy...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50330918((1R,4R)-5-(4-(3-(1H-indazol-4-yl)-2-(pyridin-4-yl)...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of BRAFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM26526((2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylqui...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of TACE in human whole blood assayMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50118983(1-Benzoyl-4-(4-methoxy-benzenesulfonyl)-2,3,4,5-te...)
Affinity DataIC50:  0.600nMAssay Description:Concentration required in vitro to inhibit Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50303131(2-chloro-5-[13-(hydroxymethyl)-15-methyl-5-(pyridi...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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