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Found 364 with Last Name = 'liang' and Initial = 'f'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  0.0180nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-P...)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100715(2-(6-Bromo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]hepta...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143320((+)-epibatidine | (-)-1-epidatidine | (1S,2S,4R)-2...)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100707((R)-2-(6-Fluoro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]...)
Affinity DataKi:  0.0270nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100717(2-(pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane | 2-P...)
Affinity DataKi:  0.0310nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143320((+)-epibatidine | (-)-1-epidatidine | (1S,2S,4R)-2...)
Affinity DataKi:  0.0450nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50143314((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Affinity DataKi:  0.0580nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100712(2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptan...)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100706(2-Bromo-5-(1-methyl-pyrrolidin-2-yl)-pyridine | CH...)
Affinity DataKi:  0.450nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100712(2-(6-Iodo-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptan...)
Affinity DataKi:  0.480nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50078056(2-Chloro-5-(1-methyl-pyrrolidin-2-yl)-pyridine | C...)
Affinity DataKi:  0.630nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1.01nMAssay Description:Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100709(2-Fluoro-5-(1-methyl-pyrrolidin-2-yl)-pyridine | C...)
Affinity DataKi:  1.03nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  1.26nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100713(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ylamin...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100708(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridine-2-sulfo...)
Affinity DataKi:  8.5nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100711(CHEMBL56677 | [5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-p...)
Affinity DataKi:  26.4nMAssay Description:Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100716(5-(1-Methyl-pyrrolidin-2-yl)-pyridin-2-ylamine | C...)
Affinity DataKi:  81nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100714(5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-2-ol | C...)
Affinity DataKi:  107nMAssay Description:Inhibition of [3H]pibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50253141([(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,...)
Affinity DataKi:  600nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50253100([(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-...)
Affinity DataKi:  900nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50253142([(2R,3S,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50100710(5-(1-methylpyrrolidin-2-yl)pyridin-2-ol | 6-hydrox...)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of [3H]-nicotine binding at the nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
University Of Rhode Island

Curated by ChEMBL
LigandPNGBDBM50377969(CHEMBL1162297)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100728(US8507676, 78)
Affinity DataIC50:  0.400nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100726(US8507676, 77-S)
Affinity DataIC50:  0.480nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163201(US9062045, 40)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163213(US9062045, 53)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163224(US9062045, 67)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163174(US9062045, 13)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163205(US9062045, 44)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163169(US9062045, 8)
Affinity DataIC50:  1nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100724(US8507676, 75-S)
Affinity DataIC50:  1.20nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163215(US9062045, 55)
Affinity DataIC50:  1.30nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100659(US8507676, 8)
Affinity DataIC50:  1.80nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163183(US9062045, 24)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163189(US9062045, 30)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163180(US9062045, 21)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163212(US9062045, 52)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163164(US9062045, 3)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163217(US9062045, 57)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163175(US9062045, 14)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163204(US9062045, 43)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163234(US9062045, 78)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163199(US9062045, 38)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM163198(US9062045, 37)
Affinity DataIC50:  2nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100674(US8507676, 23)
Affinity DataIC50:  2.20nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM100673(US8507676, 22)
Affinity DataIC50:  2.40nMAssay Description:The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...More data for this Ligand-Target Pair
In DepthDetails US Patent
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