Compile Data Set for Download or QSAR
maximum 50k data
Found 657 with Last Name = 'liu' and Initial = 'kk'
TargetD(3) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.0850nMAssay Description:Displacement of [3H]Spiperone from dopamine D3 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataKi:  0.110nMAssay Description:Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428107(CHEMBL2331664 | PF-04979064 | US8791131, 257)
Affinity DataKi:  0.111nMAssay Description:Inhibition of human PI3KgammaMore data for this Ligand-Target Pair
LigandPNGBDBM50428107(CHEMBL2331664 | PF-04979064 | US8791131, 257)
Affinity DataKi:  0.122nMAssay Description:Inhibition of human PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428107(CHEMBL2331664 | PF-04979064 | US8791131, 257)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428109(CHEMBL2331668 | US8791131, 259)
Affinity DataKi:  0.191nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428109(CHEMBL2331668 | US8791131, 259)
Affinity DataKi:  0.243nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428107(CHEMBL2331664 | PF-04979064 | US8791131, 257)
Affinity DataKi:  0.299nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336407(4-amino-2,6-dimethyl-N-(1H-pyrrolo[2,3-b]pyridin-5...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380320(CHEMBL2017653)
Affinity DataKi:  0.350nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428111(CHEMBL2331666 | US8791131, 153)
Affinity DataKi:  0.377nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428108(CHEMBL2331669 | US8791131, 255)
Affinity DataKi:  0.395nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50336405(4-amino-2-methyl-N-(6-methylpyridin-3-yl)quinazoli...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336410(4-amino-N-(6-methoxypyridin-3-yl)-2,6-dimethylquin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336406(4-amino-2,6-dimethyl-N-(6-methylpyridin-3-yl)quina...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.532nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428115(CHEMBL2331661 | US8791131, 136)
Affinity DataKi:  0.542nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataKi:  0.570nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
LigandPNGBDBM50428110(CHEMBL2331667 | US8791131, 254)
Affinity DataKi:  0.584nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304826((S)-7-(2-chlorophenoxy)-2-((R)-2-methylpiperazin-1...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380321(CHEMBL2017654)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50443101(Cariprazine | RGH-188)
Affinity DataKi:  0.690nMAssay Description:Displacement of [3H]Spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  0.700nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327904(2-amino-4-methyl-6-(1H-pyrazol-3-yl)-8-(tetrahydro...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.842nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50327907(CHEMBL1257295 | trans-2-amino-8-(4-hydroxycyclohex...)
Affinity DataKi:  0.850nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataKi:  0.900nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428111(CHEMBL2331666 | US8791131, 153)
Affinity DataKi:  0.922nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304808(4-chloro-2-(piperazin-1-yl)thieno[2,3-d]pyrimidine...)
Affinity DataKi:  1nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50336418(4-amino-2-methyl-N-(1H-pyrrolo[2,3-b]pyridin-5-yl)...)
Affinity DataKi:  1nMAssay Description:Inhibition of PI3Kalpha by fluorescene polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataKi:  1.10nMAssay Description:Competitive inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-alpha-methylglucoside uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50428117(CHEMBL2331657)
Affinity DataKi:  1.40nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428107(CHEMBL2331664 | PF-04979064 | US8791131, 257)
Affinity DataKi:  1.40nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50428110(CHEMBL2331667 | US8791131, 254)
Affinity DataKi:  1.60nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380314(CHEMBL2017648)
Affinity DataKi:  1.70nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM153901(US8999981, A146)
Affinity DataKi:  1.70nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314616((S)-N-(4-(cyclohexylmethoxy)-5-fluoro-2-methoxyben...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380315(CHEMBL2017649)
Affinity DataKi:  1.80nMAssay Description:Inhibition of PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM153898(US8999981, A143)
Affinity DataKi:  1.90nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:Protein Kinase C beta 2 (PKC beta II) catalyzes the production of ADP from ATP that accompanies the phosphoryl transfer to the PKC Pseudosubstrate pe...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428114(CHEMBL2331662 | US8791131, 173)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse PI3KalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50159358(CHEMBL3787386)
Affinity DataKi:  2nMAssay Description:Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50159347(CHEMBL3787662 | US9586965, Cpd 1)
Affinity DataKi:  2nMAssay Description:Reversible binding affinity to human EGFR L858R/ T790M double mutant expressed in baculovirus by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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