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Found 251 with Last Name = 'lukas' and Initial = 's'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Src protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Brutons tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126739(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-(3-pyr...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126735(7-(3-Amino-propenyl)-2-(2,6-dichloro-phenylamino)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Protein tyrosine kinase LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126751(2-(2,6-Dichloro-phenylamino)-7-(3-ethylamino-prope...)
Affinity DataIC50:  2nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126746(2-(2,6-Dichloro-phenylamino)-7-(3-dimethylamino-pr...)
Affinity DataIC50:  3nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126749(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-(3-mor...)
Affinity DataIC50:  4nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126752(2-(2,6-Dichloro-phenylamino)-7-(2-hydroxy-vinyl)-1...)
Affinity DataIC50:  9nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126743(7-[3-(Benzyl-methyl-amino)-propenyl]-2-(2,6-dichlo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30273(carboline analog, 85)
Affinity DataIC50:  10nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  12nMAssay Description:Inhibition of c-SRC with 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30265(carboline analog, 77)
Affinity DataIC50:  17nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116401(6,7-Dimethyl-2-(2,4,6-trichloro-phenylamino)-1,8-d...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30268(carboline analog, 80)
Affinity DataIC50:  21nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126734(2-(2,6-Dichloro-phenylamino)-1,6,7-trimethyl-1,8-d...)
Affinity DataIC50:  23nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116405(6,7-Dimethyl-2-(2,4,6-tribromo-phenylamino)-1,8-di...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126736(2-(2,6-Dichloro-phenylamino)-4-[(2-hydroxy-ethylam...)
Affinity DataIC50:  26nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126730(2-(2,6-Dichloro-phenylamino)-6-(2-hydroxy-ethyl)-1...)
Affinity DataIC50:  27nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116399(2-(2-Chloro-6-methyl-phenylamino)-6,7-dimethyl-1,8...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126738(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(2-mor...)
Affinity DataIC50:  30nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30269(carboline analog, 81)
Affinity DataIC50:  31nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30264(carboline analog, 76)
Affinity DataIC50:  34nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30266(carboline analog, 78)
Affinity DataIC50:  35nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30271(carboline analog, 83)
Affinity DataIC50:  44nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126748(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-7-vinyl-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30270(carboline analog, 82)
Affinity DataIC50:  45nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126756(2-(2,6-Dichloro-phenylamino)-4-(2,6-difluoro-pyrid...)
Affinity DataIC50:  50nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30262(carboline analog, 74)
Affinity DataIC50:  72nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30259(carboline analog, 71)
Affinity DataIC50:  83nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126731(3-[2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-9-oxo...)
Affinity DataIC50:  86nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126759(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-9-oxo-8,...)
Affinity DataIC50:  87nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116391(2-(2,6-Dichloro-phenylamino)-6,7-dimethyl-1,8-dihy...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126753(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-mor...)
Affinity DataIC50:  110nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126760(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(3-mor...)
Affinity DataIC50:  120nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126747(2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(2-mor...)
Affinity DataIC50:  120nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30261(carboline analog, 73)
Affinity DataIC50:  120nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30267(carboline analog, 79)
Affinity DataIC50:  124nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  150nMAssay Description:Inhibition of Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116408(2-(2-Chloro-phenylamino)-6,7-dimethyl-1,8-dihydro-...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126755(2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-9-oxo-8,...)
Affinity DataIC50:  170nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126744(2-(2,6-Dichloro-phenylamino)-4-[(4-methoxy-benzyla...)
Affinity DataIC50:  180nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30272(carboline analog, 84)
Affinity DataIC50:  250nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30263(carboline analog, 75)
Affinity DataIC50:  333nMAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126729(3-[2-(2,6-Dichloro-phenylamino)-1,6-dimethyl-9-oxo...)
Affinity DataIC50:  360nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116398(2-(2,6-Dichloro-phenylamino)-1,6,7,8-tetrahydro-im...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against recombinant human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126732(2-(2,6-Dichloro-phenylamino)-7-(3-diethylamino-pro...)
Affinity DataIC50:  400nMAssay Description:Inhibition of Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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