TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 6.60nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 9.10nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of HCT116 cell proliferation with compounds using calcein AM Assay.More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of His-tagged human AKT1 expressed in baculovirus expression system using TC-AHA-GRPRTSSFAEG-NH2 as substrate incubated for 90 mins by mob...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
Affinity DataIC50: 71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
TargetAurora kinase B/Inner centromere protein(Homo sapiens (Human))
Emd Serono Research & Development Institute
Curated by ChEMBL
Emd Serono Research & Development Institute
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant full length GST-tagged human Aurora B (1 to 344 residues) co-expressed with N-terminal His-tagged human recombinant INCENP ...More data for this Ligand-Target Pair
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Emd Serono Research And Development Institute
Curated by ChEMBL
Emd Serono Research And Development Institute
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:In vitro kinase activity of PEGylated pyrazolopyrimidone CDK inhibitor or a 5 PEG-amine was coupled to ReactiGel agarose beads (Pierce, No. 20259).More data for this Ligand-Target Pair